Study identifies a specific protein in sensory neurons that detects mechanical itch stimuli such as an insect crawling on the skin or when one touches an object that irritates the skin.
Those with eczema who produce immunoglobulin E in response to environmental allergens are more likely to experience chronic and acute itching.
Periostin can directly activate neurons associated with itching. Blocking periostin receptors reduced itch response in mouse models of chronic allergic itching.
People with chronic itching conditions such as eczema and psoriasis are at increased risk of stress, depression, and suicidal thoughts than those without such skin conditions.
Researchers implicate the neuropeptide NPPB in generating the itching sensation symptomatic of eczema.
Researchers investigated how the nervous system interacts with the immune system to cause the inflammation and itching associated with eczema. The findings could lead to new treatment options for eczema sufferers.
