dopaminergic neurons

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dopaminergic neurons

Featured Genetics Neurology Neuroscience

·May 11, 2022·7 min read

Designer Neurons Offer New Hope for Treatment of Parkinson’s Disease

Researchers have designed a new method of converting non-neural cells into functioning neurons that are able to form synapses, dispense dopamine, and restore the function of neurons undermined by Parkinson's associated destruction of dopaminergic cells.

Featured Neuroscience Open Neuroscience Articles Psychology

·April 3, 2022·4 min read

Midbrain Projection to the Basolateral Amygdala Encodes Anxiety-Like Behaviors

A ventral tegmental area dopamine neuron circuit that projects to the basolateral amygdala selectively controls anxiety-like behaviors, but not depression-like behaviors.

Featured Neuroscience Open Neuroscience Articles Psychology

·March 23, 2022·5 min read

Motivation to Achieve Goals May Depend on Anxiety Level

The motivation to exert sustained effort to achieve a goal following stress exposure depends on an individual's level of trait anxiety. The expression of CRHR1 in dopaminergic neurons in the ventral tegmental area connects anxiety to either boosted or diminished motivation levels.

This shows a group of friends in a field

Featured Neuroscience

·December 2, 2021·4 min read

Tracking the Neurons That Make Us Social

The motivation to invest in social interactions is closely linked to the reward system via the activation of dopaminergic neurons.

Featured Neurology Neuroscience

·March 29, 2021·4 min read

Experimental Antibodies for Parkinson’s and Alzheimer’s May Cause Harmful Inflammation

A new study reveals some experimental antibody treatments for neurodegenerative disorders increase neuroinflammation. The effect was seen in human microglia, not mouse microglia. This may explain why mouse studies have shown these treatments to be effective, but the effect has not been replicated in human studies.

Featured Genetics Neurology Neuroscience

·April 27, 2020·3 min read

More evidence Parkinson’s disease may start in the gut

Enteric neurons appear to play a key role in the development of Parkinson's disease. The findings support the hypothesis and previous studies that the neurodegenerative disease may start in the gut before spreading to the brain. Researchers also found oligodendrocytes were affected during the early stages of Parkinson's, even before the loss of dopaminergic neurons.

Closeup images of neurons with markers labeled shown.

Featured Genetics Neuroscience

·March 26, 2020·3 min read

Jumping Genes Help Make Neurons in a Dish

Converting skin cells to functional brain cells relies on precise insertion of Line-1 retrotransposons.

Featured Neurology Neuroscience

·January 31, 2020·5 min read

New light shed on neuronal circuits involved in behavior, learning and dysfunction

New findings about dopaminergic neurons in the striatum could have implications for treating Parkinson's disease and Tourette syndrome.

The gut and brain are highlighted in this drawing of a man

Featured Genetics Neurology Neuroscience

·July 17, 2019·5 min read

Bacterial intestinal infections may trigger Parkinson’s disease

Mice infected with bacteria that cause mild intestinal infections exhibited Parkinson's like symptoms later in life. The findings provide a pathophysiological model in which intestinal infections may act as a trigger for Parkinson's disease.

Featured Neuroscience Open Neuroscience Articles

·May 14, 2019·4 min read

Unexplored neural circuit modulates memory strength: Fruit fly study

PPL2 neurons help modulate the strength of memories.

this is a woman holding her head while other hands are covering her face

Featured Genetics Neuroscience Open Neuroscience Articles Psychology

·May 3, 2019·5 min read

Hotspot in the genome may drive psychosis in schizophrenia and bipolar disorder

A cluster of epigenetic marks in an enhancer at IGF2 could enhance dopamine synthesis associated with psychosis in schizophrenia and bipolar disorder. The findings may help in devising more effective treatments and screening strategies for both disorders.

Featured Genetics Neurology Neuroscience

·April 5, 2019·3 min read

Parkinson’s clues seen in tiny fish could aid quest for treatments

Zebrafish study reveals how key dopaminergic neurons, which are damaged as a result of Parkinson's disease, can be regenerated. Researchers report the immune system plays a critical role in the process.

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