Cleaning and organizing can have a positive effect on our psychological wellbeing. Dr. Stacey Bedwell explores how cleaning and organizational projects around the home can help boost satisfaction, pleasure, and feelings of personal control.
The activity of a network of dopamine neurons reflects both the innate preferences for smell and taste, as well as the physiological state of fruit flies.
Rotigotine, a drug that acts on dopamine transmission, improves cognitive function in patients with mild-to-moderate Alzheimer's disease. While the drug did not help improve memory, it did improve executive function in the frontal lobe and positively impacted the ability of patients to perform activities of daily living.
Estrogen level fluctuations appear to play a role in alcohol use disorder in women. Reducing the number of estrogen receptors in the ventral tegmental area decreased binge drinking behaviors in female mouse models.
Dopamine D2 receptor overexpression in cholinergic interneurons of the nucleus accumbens may explain why some are more prone to cocaine addiction than others.
Researchers have identified both genetic and neural mechanisms associated with romantic love and attachment. The maintenance of romantic love is not only associated with subcortical brain regions but also higher-order centers of the brain. The propensity to sustain romantic love appears to also be affected by genetic variability, specifically with genes associated with dopamine, vasopressin, and oxytocin.
Dopamine receptors have different molecular features and functions depending on their anatomical location within the striatum. The findings could help develop better-targeted treatments for a range of disorders from schizophrenia to Parkinson's disease.
Trifluoperazine, a dopamine receptor antagonist commonly prescribed for schizophrenia, used in combination with radiation therapy delays the growth of glioblastoma brain tumors and prolongs survival for brain cancer.
T cells that react to alpha-synuclein are most abundant in the early stages of Parkinson's disease but tend to disappear as the disease progresses. Signs of autoimmunity can appear in Parkinson's patients up to ten years before a diagnosis of the neurodegenerative disease. The detection of T cell response could be an early biomarker for Parkinson's, long before the physical symptoms begin to manifest.