In older mice, adult neurons in the primary visual cortex with an increased number of "silent synapses" and lacking PSD-95, showed the same structural changes only seen previously in younger animals.
A clusterization approach allows researchers to analyze dendritic spines in new ways.
Using optogenetics to inhibit the JNK protein prevented synapses from shrinking in response to stress.
SETD1A, a gene associated with schizophrenia, stunts the growth and branching of dendrites and reduces the number of dendritic spines. Reinstating the normal expression of SETD1A in mouse models restored working memory function.
Chronic stress during pregnancy increases neuroinflammation. The immune changes may create circumstances in the brain, which increase susceptibility to postnatal depression.
The formation of prefrontal cortex dendritic spine formation sustains the remission of depressive related symptoms and behaviors following ketamine treatment by restoring lost spines.
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Researchers have developed a new machine learning algorithm that can autonomously and efficiently identify dendritic spines with 90% accuracy.
Researchers have identified the role Klf9 plays in the brain's response to stress. The study reports elevated levels of the protein were discovered in the hippocampus of women with MDD who faced stressful events.
A new study reports repeated stimulation enlarges dendritic spines, enabling contact with existing neural networks.
According to researchers, the size, shape and number of dendritic spines in the brain may determine whether a person develops Alzheimer's disease.
A new study reveals molecular details of what happens when axons are damaged or completely severed.
A new study reveals psychedelic substances may have a neuroprotective role when it comes to inflammation. Researchers also report psychedelics can alter signaling pathways associated with neuroplasticity.
