cytokines

Featured Neuroscience Open Neuroscience Articles

·May 20, 2020

COVID-19 cytokine storm: Possible mechanism for the deadly respiratory syndrome

SARS-CoV-2, the virus responsible for COVID-19, enters human cells by attaching to ACE2 and utilizing TMPRSS2. Drugs that block ACE2 or inhibit the enzyme could help treat the coronavirus, but only during early infection. As the infection progresses, SARS-CoV-2 becomes engulfed in human cells, reducing the number of ACE2 receptors on a cell and leading to an increase of angiotensin II in the blood. Angiotensin II triggers an inflammatory pathway, providing a positive feedback cycle, named IL-6 amplifier, resulting in excessive immune activation and the cytokine storm associated with severe COVID-19. Read More

Featured Neuroscience Psychology

·April 29, 2020

How could Covid-19 and the body’s immune response affect the brain?

Mounting evidence suggests coronavirus affects the brain, in addition to the lungs. Researchers are examining the threat COVID-19 posses to long term brain health. They speculate maternal inflammation could lead to an increased risk of autism-like behaviors and neurodevelopment deficits in children born to mothers diagnosed with coronavirus. Other studies are exploring how the virus may spread in the nervous system via synaptic transmission. Read More

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Featured Neurology Neuroscience Open Neuroscience Articles Psychology

·August 29, 2019

The ‘inflammation’ of opioid use: Research correlates inflammation in the brain and gut to negative emotional state during opioid withdrawal

Inflammation caused by opioid use to both the brain and gut may exacerbate symptoms of negative emotions associated with withdrawal. Targeting the inflammation could help alleviate the negative experiences of opioid withdrawal and prevent dependence. Read More

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Featured Neurology Neuroscience Psychology

·August 18, 2019

Immune system and mental health are connected

Researchers explore the link between the immune system and mental health disorders. Cytokines appear to play a critical role in the development and progression of mental illness. They question if administering prednisolone, a steroid that curbs inflammation, can have a beneficial effect on treating and preventing mental health problems. Read More

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Featured Genetics Neurology Neuroscience

·July 23, 2019

Fingerprint of Multiple Sclerosis Immune Cells Identified

T helper cells in the blood of patients with multiple sclerosis infiltrate the central nervous system, causing inflammation and neural damage. Read More

Featured Neuroscience

·June 4, 2019

How chronic inflammation may drive down dopamine and motivation

Computational model sheds light on the impact chronic, low-grade inflammation has on the mesolimbic dopamine system and motivational impairments. Read More

Featured Neurology Neuroscience Open Neuroscience Articles

·February 12, 2019

Obstructive Sleep Apnea Linked to Inflammation and Organ Dysfunction

A new study makes the case that obstructive sleep apnea should be viewed as a low grade chronic inflammatory disease. Read More

Featured Neurology Psychology

·December 13, 2018

How Teens Deal with Stress May Affect Immune System

A new study reports teens faced with chronic family stress have higher blood pressure and worse immune response to bacterial infections. However, those who used cognitive reappraisal had lower blood pressure, despite the pressures they faced. Read More

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·November 2, 2018

Nature of Immune Cells in Brain Discovered

Researchers have discovered how the nature of T cells help protect the brain from viruses. The findings shed light on the role the immune system plays in a number of neurodegenerative disorders. Read More

Featured Neuroscience Psychology

·July 19, 2018

Neuroinflammation Play a Critical Role in Stress Induced Depression

Researchers report repeated social defeat stress activates microglia in the medial prefrontal cortex, triggering inflammation related cytokines. This leads to impaired neural responses in the mPFC, resulting in depressive behavior. Read More