The protein Arginase-2 works through mitochondria to reduce inflammation. The findings could lead to new treatments for diseases associated with neuroinflammation, including multiple sclerosis and rheumatoid arthritis. Read More
Protein hyper-interleukin-6, a "designer protein" that has to be produced via genetic engineering, enabled a paralyzed mouse to walk again. Read More
By fusing a cytokine to a blood protein, researchers have developed a new therapy to help treat multiple sclerosis. Read More
SARS-CoV-2, the virus responsible for COVID-19, enters human cells by attaching to ACE2 and utilizing TMPRSS2. Drugs that block ACE2 or inhibit the enzyme could help treat the coronavirus, but only during early infection. As the infection progresses, SARS-CoV-2 becomes engulfed in human cells, reducing the number of ACE2 receptors on a cell and leading to an increase of angiotensin II in the blood. Angiotensin II triggers an inflammatory pathway, providing a positive feedback cycle, named IL-6 amplifier, resulting in excessive immune activation and the cytokine storm associated with severe COVID-19. Read More
Mounting evidence suggests coronavirus affects the brain, in addition to the lungs. Researchers are examining the threat COVID-19 posses to long term brain health. They speculate maternal inflammation could lead to an increased risk of autism-like behaviors and neurodevelopment deficits in children born to mothers diagnosed with coronavirus. Other studies are exploring how the virus may spread in the nervous system via synaptic transmission. Read More
Inflammation caused by opioid use to both the brain and gut may exacerbate symptoms of negative emotions associated with withdrawal. Targeting the inflammation could help alleviate the negative experiences of opioid withdrawal and prevent dependence. Read More
Researchers explore the link between the immune system and mental health disorders. Cytokines appear to play a critical role in the development and progression of mental illness. They question if administering prednisolone, a steroid that curbs inflammation, can have a beneficial effect on treating and preventing mental health problems. Read More
T helper cells in the blood of patients with multiple sclerosis infiltrate the central nervous system, causing inflammation and neural damage. Read More
Computational model sheds light on the impact chronic, low-grade inflammation has on the mesolimbic dopamine system and motivational impairments. Read More
A new study makes the case that obstructive sleep apnea should be viewed as a low grade chronic inflammatory disease. Read More
A new study reports teens faced with chronic family stress have higher blood pressure and worse immune response to bacterial infections. However, those who used cognitive reappraisal had lower blood pressure, despite the pressures they faced. Read More
Researchers have discovered how the nature of T cells help protect the brain from viruses. The findings shed light on the role the immune system plays in a number of neurodegenerative disorders. Read More
