The protein Arginase-2 works through mitochondria to reduce inflammation. The findings could lead to new treatments for diseases associated with neuroinflammation, including multiple sclerosis and rheumatoid arthritis.
A new study reports anti-inflammatories used to treat conditions like rheumatoid arthritis may also help to treat some cases of depression.
A new blood-brain barrier on a chip system is being used to study neuroinflammation, researchers report.
Chemotherapy is often blamed for memory loss and cognitive problems in cancer survivors. However, new research published in Neuroscience challenges this belief. Researchers report cognitive impairments, often referred to as Chemo Fog, may actually start as the tumor grows and develops.
SARS-CoV-2, the virus responsible for COVID-19, enters human cells by attaching to ACE2 and utilizing TMPRSS2. Drugs that block ACE2 or inhibit the enzyme could help treat the coronavirus, but only during early infection. As the infection progresses, SARS-CoV-2 becomes engulfed in human cells, reducing the number of ACE2 receptors on a cell and leading to an increase of angiotensin II in the blood. Angiotensin II triggers an inflammatory pathway, providing a positive feedback cycle, named IL-6 amplifier, resulting in excessive immune activation and the cytokine storm associated with severe COVID-19.
A new study reports the immune system could potentially be harnessed to help clear amyloid plaques in order to help in the fight against Alzheimer's disease.
Computational model sheds light on the impact chronic, low-grade inflammation has on the mesolimbic dopamine system and motivational impairments.
Mounting evidence suggests coronavirus affects the brain, in addition to the lungs. Researchers are examining the threat COVID-19 posses to long term brain health. They speculate maternal inflammation could lead to an increased risk of autism-like behaviors and neurodevelopment deficits in children born to mothers diagnosed with coronavirus. Other studies are exploring how the virus may spread in the nervous system via synaptic transmission.