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cryo-EM

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·May 12, 2021·4 min read

Study Reveals Structure of Key Receptors Involved in Memory and Learning

Researchers have uncovered the molecular structure of three major complexes of glutamate receptors in the hippocampus. The findings shed new light on the mechanisms behind memory and learning in the brain.

Featured Neuroscience Open Neuroscience Articles

·May 1, 2020·3 min read

Scientists uncover structural basis for SARS-CoV-2 inhibition by Remdesivir

Researchers have identified the structural basis for SARS-CoV-2 inhibition by the drug Remdesivir. The findings reveal a potential binding pattern that offers support for the design of new, more efficient, and specific anti-COVID-19 drugs.

Featured Neuroscience

·March 18, 2020·4 min read

Ball-and-chain inactivation of ion channels visualized by cryo-electron microscopy

Ion channels use a "ball-and-chain" mechanism to help regulate ion flow. Findings confirm a long-standing hypothesis about ion channels and provide key advances in understanding the basic biological processes at work.

Featured Genetics Neurology

·July 6, 2018·3 min read

Study Raises Doubts on a Previous Theory of Parkinson’s

A new study questions previous assumption about how Parkinson's disease develops and progresses.

Featured Neuroscience

·May 2, 2018·5 min read

Cryo-EM Structure of the Nicotine Receptor May Lead to New Therapies for Addiction

A detailed 3D structure of nicotinic acetylcholine receptors could help pave the way to developing new treatments for nicotine addiction, researchers report.

Featured Neuroscience

·October 13, 2017·5 min read

3D Atomic Structure of Ion Channel Implicated in Rare Neurodegenerative Disease

Researchers from UT Southwestern's Cryo-EM Facility have determined the 3D anatomical structure of the TRPML1 ion channel. The ion channel has been implicated in mucolipidosis type IV, a rare, genetic neurodegenerative disease.