Researchers from UT Southwestern's Cryo-EM Facility have determined the 3D anatomical structure of the TRPML1 ion channel. The ion channel has been implicated in mucolipidosis type IV, a rare, genetic neurodegenerative disease.
Ion channels use a "ball-and-chain" mechanism to help regulate ion flow. Findings confirm a long-standing hypothesis about ion channels and provide key advances in understanding the basic biological processes at work.
Researchers have identified the structural basis for SARS-CoV-2 inhibition by the drug Remdesivir. The findings reveal a potential binding pattern that offers support for the design of new, more efficient, and specific anti-COVID-19 drugs.
Researchers have uncovered the molecular structure of three major complexes of glutamate receptors in the hippocampus. The findings shed new light on the mechanisms behind memory and learning in the brain.