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CRISPR

·October 24, 2024·6 min read

In-Utero Gene Editing Could Halt Neurodevelopmental Disorders

A new study has developed a breakthrough biomedical tool that can deliver genetic material to edit faulty genes in fetal brain cells. Tested in mice, this technology offers the potential to stop the progression of neurodevelopmental conditions, like Angelman and Rett syndromes, before birth.

Featured Genetics Neuroscience

·May 20, 2024·6 min read

CRISPR Screen Unlocks Brain’s “Black Box”

Scientists have developed a groundbreaking CRISPR screening method called in vivo Perturb-seq. This innovative technique allows for rapid and scalable analysis of how genetic changes affect individual brain cells, offering new insights into the cellular drivers of neurological diseases. By understanding how specific cell types respond to genetic perturbations, researchers can identify potential therapeutic targets and develop more effective treatments.

Featured Genetics Neuroscience

·May 9, 2024·6 min read

New Tech Unlocks Secrets of Gene Regulation and Epigenetics

Researchers developed an innovative epigenome editing platform that enables precise programming of epigenetic modifications across the genome. This technology uses CRISPR to target and modify chromatin, facilitating detailed studies on how these changes affect gene expression.

Featured Genetics Neuroscience Visual Neuroscience

·May 6, 2024·7 min read

CRISPR Trial Provides Hope for Inherited Blindness

A recent clinical trial, BRILLIANCE demonstrated the safety and efficacy of CRISPR gene editing in treating inherited blindness caused by mutations in the CEP290 gene. The study involved 14 participants who received a single injection of the CRISPR/Cas9-based medicine, EDIT-101, which showed measurable improvements in 11 participants' vision.

Featured Genetics Neuroscience

·July 3, 2023·6 min read

AI Predicts CRISPR’s RNA-Targeting Effects, Revolutionizing Gene Therapy

Researchers developed a deep learning model, TIGER, that accurately predicts on- and off-target activity of RNA-targeting CRISPR tools. This new approach allows the fine-tuning of gene activity in human cells.

Featured Genetics Neuroscience Visual Neuroscience

·March 17, 2023·3 min read

CRISPR Gene-Editing Technique Reverses Vision Loss in Mice

Using a highly versatile form of CRISPR gene editing, researchers successfully restored vision in mice with retinitis pigmentosa.

Featured Genetics Neurology Neuroscience

·January 30, 2023·5 min read

How Our Brains Turn Into Smarter Disease Fighters

CRISPR gene editing created the G795A amino acid which was introduced to microglia derived from human stem cells. Researchers were able to transplant the donor microglia immune cells into humanized rodent models while administering an FDA-approved cancer drug called pexidartinib. The inclusion of the amino acid cause the donated microglia to thrive and resist the drug, while the host microglia died. The findings open the door for new methods of using microglia to treat a range of neurodegenerative disorders.

Featured Neuroscience

·January 27, 2023·6 min read

Fresh Questions About Oxytocin as the ‘Love Hormone’ Behind Pair Bonding

The "love hormone" oxytocin may not play as critical a role in bonding as previously believed. Removing the oxytocin receptor in animal models still resulted in monogamous mating, attachment, and parental bonding behaviors, although females without the receptor produced milk in smaller quantities. Findings reveal parenting and bonding aren't purely dictated by oxytocin receptors.

Featured Genetics Neurology Neuroscience

·January 20, 2023·4 min read

New Nanoparticles Deliver Therapy Brain-Wide and Edit Alzheimer’s Gene

Researchers have developed a new family of nano-scale capsules capable of carrying CRISPR gene editing tools to different organs of the body before harmlessly dissolving. The capsules were able to enter the brains of mice and successfully edit a gene associated with Alzheimer's disease.

Brain Cancer Featured Neurology Neuroscience

·January 4, 2023·4 min read

Cancer Vaccine to Simultaneously Kill and Prevent Brain Cancer Developed

A new stem cell therapy approach eliminates established brain tumors and provides long-term immunity, training the immune system to prevent cancer from returning.

Featured Genetics Neurology Neuroscience

·December 12, 2022·4 min read

CRISPR Technology Improves Huntington’s Disease Symptoms in Models

Using CRISPR gene editing to directly target RNA, researchers eliminated toxic protein buildup associated with Huntington's disease while not disrupting other human genes.

Featured Neurology Neuroscience

·August 14, 2022·5 min read

Reprogramming the Brain’s Cleaning Crew to Mop Up Alzheimer’s Disease

Using CRISPR gene editing, researchers were able to control microglia and reverse their toxic state associated with Alzheimer's disease, and put them back on track.

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CRISPR

In-Utero Gene Editing Could Halt Neurodevelopmental Disorders

CRISPR Screen Unlocks Brain’s “Black Box”

New Tech Unlocks Secrets of Gene Regulation and Epigenetics

CRISPR Trial Provides Hope for Inherited Blindness

AI Predicts CRISPR’s RNA-Targeting Effects, Revolutionizing Gene Therapy

CRISPR Gene-Editing Technique Reverses Vision Loss in Mice

How Our Brains Turn Into Smarter Disease Fighters

New Nanoparticles Deliver Therapy Brain-Wide and Edit Alzheimer’s Gene

Cancer Vaccine to Simultaneously Kill and Prevent Brain Cancer Developed

CRISPR Technology Improves Huntington’s Disease Symptoms in Models

Reprogramming the Brain’s Cleaning Crew to Mop Up Alzheimer’s Disease

Brain Mapping Unveils Secrets to Designing Livable, People-Centric Cities

Alcohol Use Predicts Escalating Cannabis Vaping Among Youth

The Secret to Raising Independent Kids? Let Them Learn on Their Own

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