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CRISPR

·June 11, 2025·5 min read

Hidden Protein Defects Behind Autism Identified

Researchers have created a standardized mouse stem cell library containing 63 genetic variants strongly linked to autism spectrum disorder. Using CRISPR gene editing, the team generated mice and diverse tissues from these modified cells, allowing them to model autism at both the cellular and organismal level.

Featured Genetics Neuroscience

·May 22, 2025·6 min read

CRISPR Delivers RNA to Repair Neurons Right Where It’s Needed

Researchers have developed a new CRISPR-based technology that transports RNA to exact locations within neurons, where it can trigger repair and regrowth—offering hope for treating neurological diseases and injuries. Unlike traditional CRISPR tools that edit DNA, this system repurposes CRISPR-Cas13 to act like a “mailman,” carrying RNA to damaged sites using built-in molecular zip codes.

Autism Featured Genetics Neuroscience

·October 24, 2024·6 min read

In-Utero Gene Editing Could Halt Neurodevelopmental Disorders

A new study has developed a breakthrough biomedical tool that can deliver genetic material to edit faulty genes in fetal brain cells. Tested in mice, this technology offers the potential to stop the progression of neurodevelopmental conditions, like Angelman and Rett syndromes, before birth.

Featured Genetics Neuroscience

·May 20, 2024·6 min read

CRISPR Screen Unlocks Brain’s “Black Box”

Scientists have developed a groundbreaking CRISPR screening method called in vivo Perturb-seq. This innovative technique allows for rapid and scalable analysis of how genetic changes affect individual brain cells, offering new insights into the cellular drivers of neurological diseases. By understanding how specific cell types respond to genetic perturbations, researchers can identify potential therapeutic targets and develop more effective treatments.

Featured Genetics Neuroscience

·May 9, 2024·6 min read

New Tech Unlocks Secrets of Gene Regulation and Epigenetics

Researchers developed an innovative epigenome editing platform that enables precise programming of epigenetic modifications across the genome. This technology uses CRISPR to target and modify chromatin, facilitating detailed studies on how these changes affect gene expression.

Featured Genetics Neuroscience Visual Neuroscience

·May 6, 2024·7 min read

CRISPR Trial Provides Hope for Inherited Blindness

A recent clinical trial, BRILLIANCE demonstrated the safety and efficacy of CRISPR gene editing in treating inherited blindness caused by mutations in the CEP290 gene. The study involved 14 participants who received a single injection of the CRISPR/Cas9-based medicine, EDIT-101, which showed measurable improvements in 11 participants' vision.

Featured Genetics Neuroscience

·July 3, 2023·6 min read

AI Predicts CRISPR’s RNA-Targeting Effects, Revolutionizing Gene Therapy

Researchers developed a deep learning model, TIGER, that accurately predicts on- and off-target activity of RNA-targeting CRISPR tools. This new approach allows the fine-tuning of gene activity in human cells.

Featured Genetics Neuroscience Visual Neuroscience

·March 17, 2023·3 min read

CRISPR Gene-Editing Technique Reverses Vision Loss in Mice

Using a highly versatile form of CRISPR gene editing, researchers successfully restored vision in mice with retinitis pigmentosa.

Featured Genetics Neurology Neuroscience

·January 30, 2023·5 min read

How Our Brains Turn Into Smarter Disease Fighters

CRISPR gene editing created the G795A amino acid which was introduced to microglia derived from human stem cells. Researchers were able to transplant the donor microglia immune cells into humanized rodent models while administering an FDA-approved cancer drug called pexidartinib. The inclusion of the amino acid cause the donated microglia to thrive and resist the drug, while the host microglia died. The findings open the door for new methods of using microglia to treat a range of neurodegenerative disorders.

Featured Neuroscience

·January 27, 2023·6 min read

Fresh Questions About Oxytocin as the ‘Love Hormone’ Behind Pair Bonding

The "love hormone" oxytocin may not play as critical a role in bonding as previously believed. Removing the oxytocin receptor in animal models still resulted in monogamous mating, attachment, and parental bonding behaviors, although females without the receptor produced milk in smaller quantities. Findings reveal parenting and bonding aren't purely dictated by oxytocin receptors.

Featured Genetics Neurology Neuroscience

·January 20, 2023·4 min read

New Nanoparticles Deliver Therapy Brain-Wide and Edit Alzheimer’s Gene

Researchers have developed a new family of nano-scale capsules capable of carrying CRISPR gene editing tools to different organs of the body before harmlessly dissolving. The capsules were able to enter the brains of mice and successfully edit a gene associated with Alzheimer's disease.

Brain Cancer Featured Neurology Neuroscience

·January 4, 2023·4 min read

Cancer Vaccine to Simultaneously Kill and Prevent Brain Cancer Developed

A new stem cell therapy approach eliminates established brain tumors and provides long-term immunity, training the immune system to prevent cancer from returning.