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CRISPR

·July 3, 2023·6 min read

AI Predicts CRISPR’s RNA-Targeting Effects, Revolutionizing Gene Therapy

Researchers developed a deep learning model, TIGER, that accurately predicts on- and off-target activity of RNA-targeting CRISPR tools. This new approach allows the fine-tuning of gene activity in human cells.

Featured Genetics Neuroscience Visual Neuroscience

·March 17, 2023·3 min read

CRISPR Gene-Editing Technique Reverses Vision Loss in Mice

Using a highly versatile form of CRISPR gene editing, researchers successfully restored vision in mice with retinitis pigmentosa.

Featured Genetics Neurology Neuroscience

·January 30, 2023·5 min read

How Our Brains Turn Into Smarter Disease Fighters

CRISPR gene editing created the G795A amino acid which was introduced to microglia derived from human stem cells. Researchers were able to transplant the donor microglia immune cells into humanized rodent models while administering an FDA-approved cancer drug called pexidartinib. The inclusion of the amino acid cause the donated microglia to thrive and resist the drug, while the host microglia died. The findings open the door for new methods of using microglia to treat a range of neurodegenerative disorders.

Featured Neuroscience

·January 27, 2023·6 min read

Fresh Questions About Oxytocin as the ‘Love Hormone’ Behind Pair Bonding

The "love hormone" oxytocin may not play as critical a role in bonding as previously believed. Removing the oxytocin receptor in animal models still resulted in monogamous mating, attachment, and parental bonding behaviors, although females without the receptor produced milk in smaller quantities. Findings reveal parenting and bonding aren't purely dictated by oxytocin receptors.

Featured Genetics Neurology Neuroscience

·January 20, 2023·4 min read

New Nanoparticles Deliver Therapy Brain-Wide and Edit Alzheimer’s Gene

Researchers have developed a new family of nano-scale capsules capable of carrying CRISPR gene editing tools to different organs of the body before harmlessly dissolving. The capsules were able to enter the brains of mice and successfully edit a gene associated with Alzheimer's disease.

Brain Cancer Featured Neurology Neuroscience

·January 4, 2023·4 min read

Cancer Vaccine to Simultaneously Kill and Prevent Brain Cancer Developed

A new stem cell therapy approach eliminates established brain tumors and provides long-term immunity, training the immune system to prevent cancer from returning.

Featured Genetics Neurology Neuroscience

·December 12, 2022·4 min read

CRISPR Technology Improves Huntington’s Disease Symptoms in Models

Using CRISPR gene editing to directly target RNA, researchers eliminated toxic protein buildup associated with Huntington's disease while not disrupting other human genes.

Featured Neurology Neuroscience

·August 14, 2022·5 min read

Reprogramming the Brain’s Cleaning Crew to Mop Up Alzheimer’s Disease

Using CRISPR gene editing, researchers were able to control microglia and reverse their toxic state associated with Alzheimer's disease, and put them back on track.

Featured Neuroscience Open Neuroscience Articles

·April 29, 2022·3 min read

Clues Into a Sleep Mystery

Using gene editing to disrupt a gene in the thalamus that codes for a protein that binds to GABA boosted the activity of delta waves and promoted deep sleep in mouse models.

This shows a little girl playing with building blocks

Autism Featured Genetics Neuroscience

·December 13, 2021·5 min read

New Hope for People Living With a Genetic Cause of Autism

Gene editing may provide hope for the treatment of Fragile X, the leading genetic cause of autism.

Featured Neurology Neuroscience

·December 3, 2021·4 min read

Unique Brain Channel Combats Epileptic Seizures

The dSlo2 channel appears to play a role in suppressing hyperactivity in the brain that causes epileptic seizures.

Featured Genetics Neuroscience

·October 14, 2021·6 min read

Scientists Map Brain Circuit That Drives Activity in Fertile Females

Mouse study identifies specific neurons and a signaling pathway to regions of the hindbrain that mediate sexual reproductive activity and physical activity that appear to influence activity behaviors during ovulation. The findings may provide valuable insights into how estrogen loss during menopause disrupts this activity.

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CRISPR

AI Predicts CRISPR’s RNA-Targeting Effects, Revolutionizing Gene Therapy

CRISPR Gene-Editing Technique Reverses Vision Loss in Mice

How Our Brains Turn Into Smarter Disease Fighters

New Nanoparticles Deliver Therapy Brain-Wide and Edit Alzheimer’s Gene

Cancer Vaccine to Simultaneously Kill and Prevent Brain Cancer Developed

CRISPR Technology Improves Huntington’s Disease Symptoms in Models

Reprogramming the Brain’s Cleaning Crew to Mop Up Alzheimer’s Disease

Clues Into a Sleep Mystery

New Hope for People Living With a Genetic Cause of Autism

Unique Brain Channel Combats Epileptic Seizures

Scientists Map Brain Circuit That Drives Activity in Fertile Females

Chronic Stress and Depression Linked to Alzheimer’s Risk

Playful Brains: Early Years Play Shapes Children’s Futures

Sleep Struggles Link to Elevated Risk of Hypertension

MDMA Makes People Feel More Connected During Conversations

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