PLCG2-P522R, a genetic variant that protects against Alzheimer's disease, enhances key functions of immune cells. Read More
Study reveals how a neuropeptide called Big Dynorphin binds to the acid-sensing ion channel receptor, causing pain signals to be sent around the body. Read More
Study identifies a short gene segment crucial for brain development and information processing. The absence of the gene segment induces altered social behaviors, learning difficulties, and memory deficits, which are hallmarks of a subset of ASD. Read More
Findings may provide clues that may help researchers develop new techniques to regenerate hair cells in the inner ear and reverse hearing loss. Read More
Study reveals how a protein that transports essential amino acids across the placenta plays a role in fetal development. Deficiencies of the SNAT4 protein may result in developmental abnormalities and a higher risk of miscarriage. Read More
The ability to select specific traits, such as height or IQ, brought about by multiple genes is more complicated than most people realize. Read More
Using CRISPR to alter the expression of four schizophrenia implicated genes which harbor expression quantitative trait loci, researchers were able to mirror gene expression changes seen in postmortem brains of those suffering from three mental health disorders. Read More
The human development 'clock in a dish' opens up new avenues for research and provides a way to replicate developmental disorders. Read More
Using CRISPR gene editing, researchers introduce the SHANK3 gene variant into macaque monkeys. SHANK3 has previously been linked to autism in humans. The monkeys with the SHANK3 mutations exhibited behavioral traits and brain activity patterns similar to those seen in humans on the autism spectrum, Researchers hope the new model will facilitate new avenues of research for ASD. Read More
The chemical probe CDr20 can label microglia in living cells, researchers report. Read More
Using CRISPR-Cas9 gene editing, researchers identified actionable pathways responsible for the growth of glioblastoma stem cells. By reverse engineering brain cancer cells, multiple potential new targets for cancer treatments have been uncovered. Read More
Researchers in China successfully used CRISPR gene editing to produce five monkey clones from the fibroblasts of a donor monkey with disease phenotypes. Read More
