Using CRISPR gene editing, researchers introduce the SHANK3 gene variant into macaque monkeys. SHANK3 has previously been linked to autism in humans. The monkeys with the SHANK3 mutations exhibited behavioral traits and brain activity patterns similar to those seen in humans on the autism spectrum, Researchers hope the new model will facilitate new avenues of research for ASD.
The chemical probe CDr20 can label microglia in living cells, researchers report.
Using CRISPR-Cas9 gene editing, researchers identified actionable pathways responsible for the growth of glioblastoma stem cells. By reverse engineering brain cancer cells, multiple potential new targets for cancer treatments have been uncovered.
By optimizing neurons with CRISPR gene editing technology, researchers will have new ways to study genetic influences on brain health and disease, a new study reports.
Researchers say the new technique can help prevent transplant rejection.
Using CRISPR gene editing technology, researchers discover increased activity in neurons deficient in the CNTN5 or EHMT2 genes may cause ASD related characteristics in humans.
Using CRISPR gene editing, researchers mapped important genes for helping T helper cells. The findings could help generate new treatments to activate the immune system against infection and to attack tumor cells.
A new study reveals a defective version of astrocytes may be linked to the build up of alpha synuclein and could spur Parkinson's disease. The findings show the important role glial cells play in Parkinson's and offers insights into new targets for therapies to fight the neurodegenerative disease.