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Cold Spring Harbor Laboratory

Featured Neuroscience

·March 7, 2022·2 min read

Uncovering How Immune Cells Nurture Brain Connections

A new study in mice finds microglia help neurons grow synapses critical for cognitive function.

This shows neurons all colored in rainbow shades

Neuroscience

·May 10, 2021·3 min read

Diagramming the Brain With Colorful Connections

BARseq2 is a new technique that allows researchers to trace thousands of brain circuits simultaneously.

Electrophysiology Featured Genetics Neuroscience Psychology

·April 7, 2021·4 min read

Reversing a Genetic Cause of Poor Stress Responses in Mice

Study reveals the role the mouse gene Ophn1 plays in helpless behaviors and identified three methods in which to reverse the effect.

Featured Neuroscience Visual Neuroscience

·December 7, 2020·3 min read

Problems With Depth Perception Caused by Too Many Cells

Too many chandelier cells in the binocular region of the brain impair visual depth perception.

Featured Neuroscience

·September 28, 2020·4 min read

AI Learns to Trace Neuronal Pathways

A novel AI system recognizes a neuron in microscope images of the brain more efficiently than any previous approach. The system improves current methods of tracing neurons and their connections, which can help improve brain mapping.

Featured Genetics Neuroscience

·September 15, 2020·3 min read

Reward and Punishment Take Similar Paths in the Mouse Brain

Researchers found specific neurons in the striosome that help mice learn to avoid negative experiences.

Featured Genetics Neuroscience

·September 14, 2020·4 min read

Immune Cells Sculpt Circuits in the Brain

Microglia, immune cells that protect the brain from infection and inflammation, also appear to play a critical role in sculpting circuits in the developing brain.

Featured Neuroscience Open Neuroscience Articles

·September 9, 2020·3 min read

The Neurons That Connect Stress, Insomnia, and the Immune System

Researchers have identified a neural circuit responsible for inducing insomnia associated with stress. The same neural circuit also induces changes in the immune system.

Featured Genetics Neuroscience

·January 8, 2020·4 min read

Abnormal neuron activity manifests as parental neglect

Abnormal activation of parvalbumin neurons in the young mouse auditory cortex manifests as a result of maternal neglect.

This shows the location of the ventral pallidum in the brain

Featured Neuroscience

·December 31, 2019·3 min read

How the brain balances pleasure and pain

Different classes of neurons in the ventral pallidum control positive and negative motivations, sending opposing signals along a shared motivation-processing circuit.

Featured Neuroscience

·November 18, 2019·5 min read

The difference between an expert’s brain and a novice’s

When learning a new task, brain activities alter over time as mice transition to an expert from a novice. The changes are reflected in neural networks and neural activity. As the animal's knowledge grows, neural networks become more focused.

Featured Genetics Neuroscience Open Neuroscience Articles

·March 13, 2019·4 min read

New Cell Subtypes Classified in Mouse Brain

A new process for classifying neurons in the brains of mice has been outlined by researchers from Cold Spring Harbor Laboratory. The platform pairs microscopy with genetic labeling at single neuron resolution, allowing researchers to reconstruct the brain, by providing information on every neuronal type's location.