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          cocaine addiction

          This shows a brain.
          FeaturedGeneticsNeuroscience
          ·June 2, 2025·6 min read

          How Cocaine Hijacks the Brain

          In a groundbreaking study, researchers have engineered fruit flies that voluntarily consume cocaine, creating the first fly model for cocaine addiction. Typically, flies avoid the drug due to its bitter taste, but by disabling their bitter-sensing receptors, scientists encouraged addictive behavior within just 16 hours of exposure.
          Read More
          This shows a brain.
          FeaturedGeneticsNeuroscience
          ·April 12, 2025·5 min read

          Brain Enzyme Limits Risk of Drug Relapse

          New research reveals that the enzyme HDAC5 plays a critical role in suppressing a gene (Scn4b) that regulates brain activity associated with drug-related memories, which are central to relapse in substance use disorders (SUDs). By limiting expression of Scn4b, HDAC5 reduces the excitability of neurons in the brain’s reward system, weakening the formation of powerful drug-environment associations.
          Read More
          This shows a head.
          FeaturedNeurosciencePsychology
          ·October 5, 2023·6 min read

          Mapping the Amygdala Leads to New Hope For Cocaine Addiction

          Researchers crafted a detailed atlas of the amygdala, revealing new insights into emotional responses and potential treatments for cocaine addiction. A cell-by-cell study of the amygdala, a brain structure vital in controlling emotional reactions, has exposed previously unobserved links between addiction behaviors and genes related to energy metabolism, suggesting energy management in neurons could influence addiction-like actions.
          Read More
          This shows a brain
          FeaturedNeurosciencePsychology
          ·February 20, 2023·4 min read

          Ketamine Could Be Effective Treatment for Cocaine-Use Disorders

          Those with cocaine use disorder who were administered ketamine for depression or pain experienced two-to-four times higher remission rate.
          Read More
          This is a drawing of a mouse surrounded by chemical equations
          FeaturedNeuroscience
          ·November 1, 2022·3 min read

          How Gut Bacteria Influence the Effects of Cocaine in Mice

          Cocaine use supports the growth of Îł-proteobacteria, a common gut bacteria that consume glycine. As glycine levels become depleted mouse models exhibit a higher response to cocaine with abnormal behaviors including increased drug-induced locomotion and drug-seeking behaviors.
          Read More
          This shows brain scans from the study
          FeaturedNeurosciencePsychology
          ·October 8, 2022·4 min read

          Human Cocaine and Heroin Addiction Is Found Tied to Impairments in Specific Brain Circuit Initially Implicated in Animals

          Greater impairment of the prefrontal cortex-habenula pathway was correlated with earlier age of first drug use.
          Read More
          This shows a brain made of cog wheels
          FeaturedNeuroscience
          ·June 28, 2022·5 min read

          New Brain Mechanism Involved in Impulsive Cocaine-Seeking in Rats Discovered

          Blocking M2Rs muscarinic acetylcholine receptors in the lateral habenula with an experimental drug increased cocaine-seeking behaviors in rat models of impulsive behaviors.
          Read More
          This shows a graph from the study
          FeaturedNeurosciencePsychology
          ·November 2, 2020·2 min read

          Sleep-Deprived Mice Find Cocaine More Rewarding

          Mouse study reveals sleep deprivation can increase the risk of cocaine addiction. Too little sleep increases the reward properties of cocaine, researchers report.
          Read More
          This shows a head
          FeaturedNeurosciencePsychology
          ·October 29, 2020·4 min read

          Nucleus Accumbens Neuron Ensembles Recruited by Cocaine and Sugar Are Different

          Cocaine and sucrose neuron ensembles in the nucleus accumbens are mostly non-overlapping.
          Read More
          This shows a brain and neurons
          FeaturedNeuroscience
          ·October 17, 2020·3 min read

          Astrocytes Build Synapses After Cocaine Use

          Astrocytes respond to cocaine exposure in the brains of mice by promoting the formation of new synapses.
          Read More
          This shows a brain
          FeaturedNeuroscienceOpen Neuroscience Articles
          ·July 23, 2020·4 min read

          Mysterious Brain Structure Sheds Light on Addiction

          A new study reveals the role the claustrum plays in cocaine addiction. Inhibiting claustral neurons prevented behavioral responses to cocaine in mouse models of addiction.
          Read More
          This shows the structure of dopamine
          FeaturedGeneticsNeuroscience
          ·April 9, 2020·4 min read

          Novel role for dopamine that impacts gene expression related to cocaine abuse discovered

          Reducing H3Q5dop in rat models of cocaine withdrawal significantly reversed cocaine mediated gene expression changes and reduced cocaine-seeking behaviors.
          Read More
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          This shows astrocytes.

          Astrocytes Take the Lead: Hidden Stars of Brain Rhythms Revealed

          This shows a brain and people exercising.

          Mental Health Benefits of Exercise Depend on Context

          This shows neurons and DNA.

          Later-Born Neurons Mature Faster to Keep Networks in Balance

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          Find Exercise You Enjoy: Personality Shapes Fitness Success

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