Blocking M2Rs muscarinic acetylcholine receptors in the lateral habenula with an experimental drug increased cocaine-seeking behaviors in rat models of impulsive behaviors.
Cocaine and sucrose neuron ensembles in the nucleus accumbens are mostly non-overlapping.
A new study reveals the role the claustrum plays in cocaine addiction. Inhibiting claustral neurons prevented behavioral responses to cocaine in mouse models of addiction.
Reducing H3Q5dop in rat models of cocaine withdrawal significantly reversed cocaine mediated gene expression changes and reduced cocaine-seeking behaviors.
In men with a history of childhood trauma, oxytocin reduced the activity within the amygdala and cravings for cocaine. Women who were addicted to cocaine and had experienced childhood trauma showed an increase in amygdala activity following exposure to oxytocin.
Chronic cocaine use alters the epigenetic profile of the FosB gene in the hippocampus. These alterations are required for cocaine-dependent gene expression and cocaine environment associations. Modification of hippocampal FosB results in a condition critical for cocaine-related learning.
Teens who use anabolic steroids are at increased risk of cocaine use disorder, researchers report.
Disrupting memories associated with environmental cues significantly reduces cocaine seeking behaviors in rat models of addiction, a new study reports.
Researchers report the release of dopamine alters when working to obtain cocaine. The study reports, the more effort it takes to secure a supply of the illicit drug, the lower the release of dopamine when taking cocaine.
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Using deep learning technology in combination with neuroimaging data, researchers were able to accurately predict who would abstain from cocaine during treatment for addiction.