Circadian rhythm disruptions in older men have been linked to an increased risk of developing Parkinson's disease. The findings suggest circadian disruptions may reflect the neurodegenerative processes already affecting the brain's internal clock prior to the diagnosis of Parkinson's. Circadian disruptions, researchers say, could be considered an early warning sign of Parkinson's.
Researchers uncover an intimate connection between methylation and the body's circadian rhythms.
Recovered stroke patients who suffer from sleep-wake disruptions are more likely to experience another stroke, researchers report.
A new study puts into question conventional belief that the eyes communicate with the brain exclusively via one signaling pathway. Researchers have identified a subset of retinal neurons that sends inhibitory signals to the brain. This subset of neurons is also involved in the synchronization of circadian rhythms to light/dark cycles and pupil constriction to bright light intensity.
Two small molecules, KL101 and TH301, are the first compounds that selectively target circadian clock components CRY1 and CRY2.
Older children have stronger neural responses to rewards over punishments later in the afternoon. In younger children, this pattern is reversed.
Inconsistent bedtimes and irregular sleep patterns could more than double the risk of developing cardiovascular disease.
Losing weight isn't just a case of restricting the foods or calories you eat, it also comes down to when you eat. Skipping breakfast and snacking late at night delays the body's fat-burning mechanisms.
Deleting the circadian rhythm-associated BMAL1 gene in animal models, researchers discovered tissue continued to follow a 24-hour rhythm, even in the absence of external stimuli that can influence the cycle.
Study reveals how certain genetic mutations can shorten the timing of the circadian clock, making some people extreme "morning larks" because their internal clock operates on a 20-hour cycle, as opposed to a 24-hour cycle.
Researchers identified molecules that can modulate circadian rhythms by binding to the MT1 melatonin receptor in the hypothalamus.