Enhanced reactivation of negative memory engrams may be an important cellular mechanism behind the cognitive symptoms of depression.
Hippocampal neurons become longer and stronger following a period of sleep deprivation. The study supports the hypothesis that sleep may weaken synapses, which are strengthened from learning, allowing for learning to occur after waking.
A pairing of presynaptic and postsynaptic activity in a population of hippocampal neurons can reduce the required number of synaptic plasticity evoking events. When spikes occur within ten milliseconds of each other, synapses strengthen for up to four hours.
Multisensory gamma wave stimulation improves recognition and spatial memory, in addition to reducing amyloid in the auditory cortex and hippocampal CA1 areas of mice. Findings suggest such sensory stimulation boosts hippocampal function and reduces Alzheimer's linked pathologies throughout the neocortex.
New findings back up recent hippocampal research in rodents, providing evidence of a common hippocampal neural mechanism representing temporal information in episodic memory.
Researchers report adolescent rats exposed to high fructose corn syrup in their diets were more prone to experience symptoms associated with bipolar disorder.
Study reveals the hippocampus may overlay existing mental maps with information about reward and hazard derived from food found in specific locations.
A new mouse study reveals a small cluster of interneurons in the hippocampus help the brain remember the places that matter the most. The findings could have implications for future studies of psychiatric disorders.