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BBB

·December 17, 2022·5 min read

Why Does the Alzheimer’s Brain Become Insulin-Resistant?

Insulin binding receptors are predominantly located in the microvessels within the blood-brain barrier. In patients with Alzheimer's, the abundance of these receptors is decreased. This decrease could lead to the loss of insulin response in the Alzheimer's brain.

Featured Genetics Neurology Neuroscience

·November 22, 2022·4 min read

Gene-Delivering Viruses Reach the Brain in Step Toward Gene Therapy for Neurological Diseases

Researchers have developed a family of adeno-associated viral vectors (AAVs) that are able to cross the blood-brain barrier to deliver gene therapies directly to the brain.

Brain Cancer Featured Neuroscience

·June 1, 2022·5 min read

Engineers Develop Nanoparticles That Cross the Blood-Brain Barrier

Researchers have developed drug-carrying nanoparticles that cross the blood-brain barrier, allowing for more effective delivery to the brain than conventional medications. The nanoparticles can get into tumors and kill glioblastoma brain cancer cells.

Featured Neuroscience

·January 31, 2022·6 min read

Precisely Opening a Gate to the Brain in Mice

A newly developed technique allows researchers to consistently and reproducibly open the blood-brain barrier in animal models.

Featured Neuroscience

·July 5, 2021·3 min read

Nanomaterials Shape and Form Influences Their Ability to Cross the Blood Brain Barrier

Silver and zinc oxide nanomaterials are able to pass through an in vitro blood-brain barrier model in the form of both particles and dissolved ions.

Featured Neuroscience

·June 16, 2021·6 min read

Omega-3s May Hold Key to Unlocking Blood-Brain Barrier

A new imaging study reveals how the MFSD2A transporter protein provides a gateway for omega-3 fatty acids to enter the brain.

Featured Neurology Neuroscience

·May 8, 2021·3 min read

New MRI Technique Can Detect Early Dysfunction of the Blood-Brain Barrier With Small Vessel Disease

DP-ASL, a new neuroimaging technique may help researchers identify early blood-brain barrier dysfunction associated with SVD.

Electrophysiology Featured Neuroscience Psychology

·April 24, 2021·6 min read

The Immune Link Between a Leaky Blood-Brain Barrier and Schizophrenia

People with schizophrenia and other neuropsychiatric disorders may have a more permissive blood-brain barrier which allows the immune system to become more actively involved in the central nervous system. The resulting inflammation may contribute to the clinical manifestation of psychosis-like symptoms.

Featured Genetics Neurology Neuroscience

·March 18, 2021·4 min read

Could Leak in Blood-Brain Barrier Be Cause of Poor Memory?

Researchers investigate the role the blood-brain barrier may play in age-related memory problems.

Featured Genetics Neurology Neuroscience

·March 16, 2021·3 min read

How Sex Differences Play a Role in Neurological Diseases

Separating vascular cell data based on sex helps researchers make new discoveries about why males and females are affected by neurodegenerative diseases differently. Findings point to differences in the blood-brain barrier between males and females.

Featured Neurology Neuroscience

·February 22, 2021·4 min read

Target for Stroke Therapy in Blood-Brain Barrier Discovered

The stroke byproduct acrolein activates the precursor of heparanase, an enzyme that degrades the glycocalyx in the blood-brain barrier.

This shows the outline of a body and a red brain

Featured Genetics Neuroscience

·February 6, 2021·5 min read

Critical Flaw Found in Lab Models of the Human Blood-Brain Barrier

Human brain endothelial cells used to generate lab models of the human blood-brain barrier were missing several key proteins found in natural endothelial cells. The cells had more in common with epithelial, a type of cell not normally found in the brain. The findings put into question over a decade worth of lab-based research on the BBB.

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