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          FeaturedNeuroscience
          ·June 4, 2025·4 min read

          Aging Brain More Vulnerable to Even Mild Oxygen Deprivation

          New research shows that even mild, prolonged exposure to low oxygen levels can significantly disrupt the blood-brain barrier (BBB) in aging brains. Using mice aged 2 to 23 months, scientists found that older mice experienced 4–6 times more BBB breakdown than younger mice under similar hypoxic conditions.
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          This shows a brain.
          FeaturedGeneticsNeuroscience
          ·May 26, 2025·5 min read

          Nitrous Oxide Unlocks Blood-Brain Barrier for Safer Gene Delivery

          Researchers have discovered that nitrous oxide can safely enhance the delivery of gene therapy to the brain by making the blood-brain barrier (BBB) more permeable when paired with focused ultrasound (FUS). This method required significantly lower concentrations of microbubbles and ultrasound pressure than conventional techniques, reducing the risk of tissue damage.
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          This shows a brain.
          FeaturedGeneticsNeurologyNeuroscience
          ·November 25, 2024·4 min read

          New Platform Overcomes Blood-Brain Barrier for Drug Delivery

          Researchers have developed a breakthrough system to deliver large therapeutic molecules into the brain, overcoming the challenges of the blood-brain barrier.
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          This shows a brain.
          FeaturedNeuroscience
          ·June 3, 2024·4 min read

          Could Your Brain Have Its Own Microbiome?

          Recent research suggests the brain might host its own microbiome, challenging the long-held belief that it is a sterile organ. Studies have found bacterial and fungal genetic material in brain tissues, particularly in those with Alzheimer’s. The brain microbiome could be linked to diseases, offering potential new treatment avenues. However, much remains unknown about how microbes enter and affect the brain.
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          Brain CancerFeaturedNeurologyNeuroscience
          ·May 6, 2024·6 min read

          Nanoparticles Penetrate Blood-Brain Barrier to Treat Cancer

          Researchers developed a novel nanoparticle that can cross the blood-brain barrier to target both primary breast tumors and brain metastases simultaneously. This dual-action approach utilizes a biodegradable polymer loaded with two prodrugs targeting cancer cell mitochondria.
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          This shows a brain.
          FeaturedNeuroscience
          ·September 26, 2023·3 min read

          Probing E-Cig and Alcohol’s Joint Assault on the Blood-Brain Barrier

          E-cigarettes, popular among teens, have been linked to increased alcohol and drug consumption. Now, with NIH funding, researchers seeks to understand the effects of combining e-cigarettes and alcohol on our brain's protective layer: the blood brain barrier.
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          This shows the outline of a head
          FeaturedNeurologyNeuroscience
          ·February 27, 2023·3 min read

          Researchers Detail Changes in the Blood-Brain Barrier Related to Alzheimer’s Disease

          In those with Alzheimer's disease, the choroid plexus becomes enlarged and has increased accumulation of abnormal inflammatory signatures.
          Read More
          This shows the outline of a head
          FeaturedNeurologyNeuroscience
          ·December 17, 2022·5 min read

          Why Does the Alzheimer’s Brain Become Insulin-Resistant?

          Insulin binding receptors are predominantly located in the microvessels within the blood-brain barrier. In patients with Alzheimer's, the abundance of these receptors is decreased. This decrease could lead to the loss of insulin response in the Alzheimer's brain.
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          This shows the outline of a head
          FeaturedGeneticsNeurologyNeuroscience
          ·November 22, 2022·4 min read

          Gene-Delivering Viruses Reach the Brain in Step Toward Gene Therapy for Neurological Diseases

          Researchers have developed a family of adeno-associated viral vectors (AAVs) that are able to cross the blood-brain barrier to deliver gene therapies directly to the brain.
          Read More
          This shows tumor cells
          Brain CancerFeaturedNeuroscience
          ·June 1, 2022·5 min read

          Engineers Develop Nanoparticles That Cross the Blood-Brain Barrier

          Researchers have developed drug-carrying nanoparticles that cross the blood-brain barrier, allowing for more effective delivery to the brain than conventional medications. The nanoparticles can get into tumors and kill glioblastoma brain cancer cells.
          Read More
          This shows a mouse brain
          FeaturedNeuroscience
          ·January 31, 2022·6 min read

          Precisely Opening a Gate to the Brain in Mice

          A newly developed technique allows researchers to consistently and reproducibly open the blood-brain barrier in animal models.
          Read More
          This shows a brain
          FeaturedNeuroscience
          ·July 5, 2021·3 min read

          Nanomaterials Shape and Form Influences Their Ability to Cross the Blood Brain Barrier

          Silver and zinc oxide nanomaterials are able to pass through an in vitro blood-brain barrier model in the form of both particles and dissolved ions.
          Read More
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          Gene Therapy Restores Hearing in Those with Deafness

          This shows a brain.

          Forever Chemicals May Disrupt Brain Development

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          Kids Outsmart AI in Puzzle Game That Builds Critical Thinking

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          Drug-Coated Neural Implants Reduce Immune Rejection

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