A new nanoparticle drug-delivery system resulted in unprecedented siRNA penetration across the intact blood-brain barrier. Researchers say the system could help doctors to treat secondary injuries associated with TBI that can result in Alzheimer's and other neurodegenerative disorders.
A new study reports damage to the blood-brain barrier can cause age related cognitive decline, and sheds light on how we could reverse the aging process in the brain.
Researchers have discovered how the parasite Toxoplasma gondii is able to cross the blood-brain barrier.
A new study reports microglia are responsible for maintaining and repairing the blood-brain barrier.
The stroke byproduct acrolein activates the precursor of heparanase, an enzyme that degrades the glycocalyx in the blood-brain barrier.
Researchers have successfully bypassed the blood-brain barrier using a laser probe to help deliver chemotherapy drugs to glioblastoma patients.
People with schizophrenia and other neuropsychiatric disorders may have a more permissive blood-brain barrier which allows the immune system to become more actively involved in the central nervous system. The resulting inflammation may contribute to the clinical manifestation of psychosis-like symptoms.
Researchers use focused ultrasound to safely and non-invasively open the blood-brain barrier in Alzheimer's patients.
Microglia initially protects the blood-brain barrier from damage due to systemic inflammation. However, microglia can alter their behavior and increase the permeability of the blood-brain barrier, thus damaging it.