A new study reports leaky capillaries in the brain may be an early sign of Alzheimer's disease as it can signal cognitive impairment prior to the buildup of proteins associated with the neurodegenerative disease.
Separating vascular cell data based on sex helps researchers make new discoveries about why males and females are affected by neurodegenerative diseases differently. Findings point to differences in the blood-brain barrier between males and females.
A synthesized small-molecule drug blocks the TGF-beta receptor in astrocytes and traverses the blood-brain barrier in mice. When administered, the drug lowered receptor activity to that seen in younger mice and reduced inflammation. The aged mice were able to navigate mazes and learn spatial tasks as well as younger mice.
A new study outlines how researchers have been able to deliver concentrated amounts of drugs directly into the brains of rats by using ultrasound.
Researchers have developed a family of adeno-associated viral vectors (AAVs) that are able to cross the blood-brain barrier to deliver gene therapies directly to the brain.
A new math model has helped researchers to uncover the progression of HIV infection in the brain.
DP-ASL, a new neuroimaging technique may help researchers identify early blood-brain barrier dysfunction associated with SVD.
Researchers have developed a cyclic peptide that can enhance blood-brain barrier penetration.
Researchers develop a new technique which allows drugs to be delivered across the blood-brain barrier.
Pericytes could provide novel targets for the treatment and diagnosis of Alzheimer's disease, a new study reports.