In those with Alzheimer's disease, the choroid plexus becomes enlarged and has increased accumulation of abnormal inflammatory signatures.
Insulin binding receptors are predominantly located in the microvessels within the blood-brain barrier. In patients with Alzheimer's, the abundance of these receptors is decreased. This decrease could lead to the loss of insulin response in the Alzheimer's brain.
Researchers have developed a family of adeno-associated viral vectors (AAVs) that are able to cross the blood-brain barrier to deliver gene therapies directly to the brain.
Researchers have developed drug-carrying nanoparticles that cross the blood-brain barrier, allowing for more effective delivery to the brain than conventional medications. The nanoparticles can get into tumors and kill glioblastoma brain cancer cells.
A newly developed technique allows researchers to consistently and reproducibly open the blood-brain barrier in animal models.
Silver and zinc oxide nanomaterials are able to pass through an in vitro blood-brain barrier model in the form of both particles and dissolved ions.
A new imaging study reveals how the MFSD2A transporter protein provides a gateway for omega-3 fatty acids to enter the brain.
DP-ASL, a new neuroimaging technique may help researchers identify early blood-brain barrier dysfunction associated with SVD.
People with schizophrenia and other neuropsychiatric disorders may have a more permissive blood-brain barrier which allows the immune system to become more actively involved in the central nervous system. The resulting inflammation may contribute to the clinical manifestation of psychosis-like symptoms.
Researchers investigate the role the blood-brain barrier may play in age-related memory problems.
Separating vascular cell data based on sex helps researchers make new discoveries about why males and females are affected by neurodegenerative diseases differently. Findings point to differences in the blood-brain barrier between males and females.
The stroke byproduct acrolein activates the precursor of heparanase, an enzyme that degrades the glycocalyx in the blood-brain barrier.
