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BACE1

·June 22, 2016·4 min read

Long Term Use of Anticholinergic Drugs Increases Alzheimer’s Risk

Study reveals long term use of anticholinergic drugs, such as those used to treat allergies, can increase the risk of developing Alzheimer's disease later in life.

Featured Neurology Open Neuroscience Articles

·June 21, 2016·4 min read

New Link Found Between Diabetes and Alzheimer’s

Researchers report a drug used to treat diabetes may be successful at treating Alzheimer's disease also.

Diagram shows how the drugs will target BACE1.

Featured Neurology Open Neuroscience Articles

·February 25, 2016·3 min read

Blocking the Harmful Behavior of a Key Alzheimer’s Enzyme

Researchers present a new therapeutic strategy that could help patients with Alzheimer's disease.

This image shows a brain slice from a healthy brain and a slice from the brain of an alzheimer's patient.

Featured Genetics Neurology

·July 29, 2015·4 min read

Protein Fragment Produced in the Brain Inhibits Enzyme Implicated in Alzheimer’s Disease

A new study reports a naturally occurring protein fragment produced in the brain can inhibit a key enzyme implicated in the onset of Alzheimer's disease.

This image is a photo of a plastinated Alzheimer's brain.

Featured Genetics Neurology Open Neuroscience Articles

·July 21, 2015·4 min read

New Culprit in Alzheimer’s Disease Development Identified

Researchers have implicated a new culprit in the development of Alzheimer's disease. The findings could influence new strategies for treatment.

This image shows Lysosomes (in magenta) accumulate near amyloid plaques.

Featured Neurology

·June 30, 2015·3 min read

Lysosomes Failure to Perform May Contribute to Alzheimer’s Disease

According to new research, in Alzheimer's patients, lysosomes lack the ability to perform their job correctly.

The image shows BACE1 and APP in the alzheimer's brain slices. The caption best describes the image.

Featured Genetics Neurology Open Neuroscience Articles

·January 15, 2015·5 min read

Alzheimer’s Plaques Reduced by Targeting Sugar Attachment to the BACE1 Enzyme

Amyloid beta can be reduced when sugars are prevented from binding to a key enzyme associated with Alzheimer's disease, researchers report.

The image shows PET scans of a person's brain with Alzheimer's disease.

Featured Neurology

·June 21, 2013·3 min read

Alzheimer’s Disease Protein Controls Movement in Mice

Researchers reveal the Bace1 protein, well known for its role in Alzheimer's disease, controls spindle development in muscles and leads to impaired movement when absent.

Featured Neurology

·August 20, 2012·2 min read

Brain Enzyme is Double Whammy for Alzheimer’s Disease

Researchers discover that an enzyme known for generating toxic brain plaques in Alzheimer's disease also causes additional memory and cognitive deficits via a separate mechanism. They found that BACE1 disrupts the cell's production of other molecules required for PKA function. By that mechanism, BACE1 inactivates PKA and therefore inhibits memory formation in mice, even in the absence of neurotoxic β-amyloid.

Featured Neurology

·July 24, 2012·4 min read

New Research Determines How a Single Brain Trauma May Lead to Alzheimer’s Disease

A study, performed in mice and utilizing post-mortem samples of brains from patients with Alzheimer’s disease, found that a single event of a moderate-to-severe traumatic brain injury (TBI) can disrupt proteins that regulate an enzyme associated with Alzheimer’s. The paper, published in The Journal of Neuroscience, identifies the complex mechanisms that result in a rapid and robust post-injury elevation of the enzyme, BACE1, in the brain. These results may lead to the development of a drug treatment that targets this mechanism to slow the progression of Alzheimer’s disease.