Researchers have developed small molecules that inhibit one of the main enzymes implicated in autoimmune response. The research could lead to potential new medications for a range of autoimmune diseases.
Rare gene variants BLK and BANK1 are present in a substantial percentage of people with Lupus. The genetic variants suppress 1RF5 and type-1 1Fn in B cells, causing dysfunction in the immune cells.
Chronic social stress in mice induces the expression of virulent genes in the gut microbiota. The altered microbiota increases the presence of effector T helper cells in the lymph nodes and induces myelin autoreactive cells. Exposure to chronic stress, therefore, may increase the risk of developing autoimmune diseases for some individuals with a susceptibility.
In uveitis, microglia facilitates the entry of inflammatory immune cells into the retina, enabling the host immune responses to attack cells not normally recognized by the immune system.
Skin cells may hold the key to explaining why women are more prone to developing autoimmune diseases, such as lupus than men. Researchers found women have more VGLL3 in their skin cells than men. VGLL3 pushes the immune system into overdrive, resulting in the 'self-attacking' autoimmune response, the mouse study revealed. Findings strongly implicate VGLL3 as a pivotal catalyst in sex-based autoimmunity.
A study in mouse models of multiple sclerosis demonstrates a compound called sobetirome promotes remyelination, and a derivative of the compound can penetrate the blood-brain barrier to enable a tenfold increase in infiltration to the CNS. Researchers are confident their research will translate from mice into humans, providing a new avenue of treatment for MS.
Non-invasive vagus nerve stimulation reduces inflammation and improves symptoms for those suffering from rheumatoid arthritis. The simulation technique helps inhibit the production of cytokines and reduces inflammatory response.
Vitamin D causes dendritic cells to produce more CD31, hindering the activation of T cells. The study sheds light on how vitamin D deficiency regulates the immune system and can lead to autoimmune diseases, like multiple sclerosis.
18% of new patients treated at two Los Angeles hospitals for multiple sclerosis were misdiagnosed with the autoimmune disease. The misdiagnosed patients were often treated unnecessarily with medications designed for MS. From their findings, researchers report the most common alternative diagnosis was migraine.
Study finds no association between mineral levels or dietary mineral intake and an increased risk of multiple sclerosis.