FeaturedGeneticsNeuroscience·September 21, 2022·6 min readCommon Alzheimer’s Gene Variant Linked to COVID MortalityMice with the Alzheimer's disease-associated APOE4 and the APOE2 genes were more likely to die from COVID-19 than those with the APOE3 gene. Those with APOE4 and APOE2 genes had more virus replication in the lungs, higher inflammation, and increased tissue damage following coronavirus infection.Read More
FeaturedGeneticsNeurologyNeuroscience·February 2, 2022·4 min readNew Non-Mutated Protein Linked to DementiaAPOE proteins were enhanced in the brains of patients with dementia, even when they did not carry the Alzheimer's associated gene.Read More
FeaturedNeurologyNeuroscience·August 14, 2021·5 min readBrain Cholesterol Regulates Alzheimer’s PlaquesA new advanced imaging technique shows how cholesterol regulates the production of Alzheimer's associated amyloid beta proteins in astrocytes.Read More
FeaturedGeneticsNeurologyNeuroscience·May 6, 2021·6 min readWhy Do Some Neurons Degenerate and Die in Alzheimer’s Disease, but Not Others?Study reveals the molecular clues as to why some neurons are susceptible to death in Alzheimer's disease while others aren't.Read More
FeaturedNeurologyNeuroscience·February 26, 2021·5 min readThe Impact of Patient Sex on Treatment Strategies for Spinal Cord InjuriesBoth the ApoE genotype and the sex of the mouse impacted the manner in which the animals with spinal cord injury responded to hypoxia treatment. Females with the ApoE e4 gene had a negative response to intermittent hypoxia.Read More
FeaturedGeneticsNeurologyNeurosciencePain·February 24, 2021·4 min readPain Perception Could Help Diagnose Alzheimer’s Before Symptoms OccurAltered pain perception could be a new biomarker to assess late-onset Alzheimer's risk in cognitively healthy individuals with the AopE4 gene before symptoms occur.Read More
FeaturedGeneticsNeurologyNeuroscience·February 21, 2021·6 min readProtein Linked to Alzheimer’s and Strokes Cleared From Brain Blood VesselsAn antibody called HAE-4 targets APOE and removes Alzheimer's related amyloid plaques in mouse models. The antibody improves blood vessel function in the brain without raising the risk of brain bleeds.Read More
FeaturedGeneticsNeurologyOpen Neuroscience Articles·September 15, 2020·5 min readRisk Gene for Alzheimer’s Has Early Effects on the BrainYoung adults with the Alzheimer's associated ApoE gene had differences in brain activity when presented with memory tasks.Read More
FeaturedGeneticsNeurologyNeuroscience·April 13, 2020·7 min readGene variant staves off Alzheimer’s in some peopleCarriers of one copy of the longevity associated klotho gene reduces Alzheimer's risks by 30% for those with genetic risk factors for the neurodegenerative disease.Read More
FeaturedNeurologyNeuroscience·March 5, 2020·3 min readExercise may slow brain aging by 4 yearsFrequent exercise, such as walking, swimming, and dancing, was associated with less brain shrinkage in older adults. The effect of exercise in older people was equal to four fewer years of brain aging.Read More
FeaturedGeneticsNeurologyNeuroscience·February 14, 2020·4 min readSubtle decline in cognition predicts progression to Alzheimer’s pathologyCognitive performance may predict the progression from normal to abnormal levels of Alzheimer's associated amyloid-beta.Read More
FeaturedGeneticsNeurologyNeuroscienceOpen Neuroscience Articles·January 5, 2020·5 min readUp to 10,000 people could be living with rare neurological disordersProgressive supranuclear palsy (PSP) and corticobasal syndrome (CBS), two atypical parkinsonian syndromes, may be twice as common as previously believed, researchers report.Read More
