anhedonia Research Articles - Neuroscience News

Why stress doesn’t always cause depression

Neuroscience NewsDecember 2, 2019

Rats susceptible to anhedonia have more serotonin neurons in the ventral dorsal raphe nucleus. However, activating neurons in the central amygdala reduced the serotonin signaling and lowered the effects of social stress.... Read More...

FeaturedNeurosciencePsychology4 min read

Promising steps towards hope for a treatment for schizophrenia

Neuroscience NewsOctober 4, 2019

Mu-opioid receptor (MOR) levels are significantly reduced in the striatum in those with schizophrenia. A lack of MOR system stimulation contributes to negative feelings, such as a lack of motivation and anhedonia, associated with the condition. Increasing MOR levels could help to reduce some of the symptoms of schizophrenia.... Read More...

FeaturedNeurosciencePsychology4 min read

Molecular link between chronic pain and depression revealed

Neuroscience NewsSeptember 26, 2019

Inhibitory inputs to the neural circuit between the dorsolateral bed nucleus of the stria terminalis (dlBNST) to the ventral tegmental area (VTA) increase when a person is in chronic pain. This alteration is mediated by enhanced corticotropin-releasing factor signaling within the dlBNST, leading to suppression of the mesolimbic dopaminergic system. The result is depressive mood and anhedonia associated with chronic pain.... Read More...

ElectrophysiologyFeaturedNeurologyNeurosciencepainPsychology5 min read

Brain circuit connects feeding and mood in response to stress

Neuroscience NewsSeptember 5, 2019

A new study identifies a novel neural network regulating feeding and mood in response to chronic stress. Inhibiting the POMC to ventral tegmental area circuit increases body weight and food intake while reducing depressive symptoms in mouse models.... Read More...

FeaturedNeurosciencePsychology5 min read

Genetic variation contributes to individual differences in pleasure

Neuroscience NewsAugust 8, 2019

What we find pleasurable may be down to our genetics. Researchers found nucleus accumbens activation and physical anhedonia were influenced by shared genes. The experience of pleasure and physical anhedonia also appear to share some of the same genes.... Read More...

FeaturedGeneticsNeurosciencePsychology6 min read

New therapeutic target for depression identified

Neuroscience NewsMay 22, 2019

A fragment of the neuropeptide Galanin appears to play a role in anhedonia in mouse models of depression. Galanin could be a potential target for the treatment of depression.... Read More...

FeaturedGeneticsNeurosciencePsychology4 min read

Inflammation induces anhedonia in women but not men

Neuroscience NewsMay 15, 2019

Inflammation appears to reduce reward response in females. Reduced activity in the brain's reward system is a key component of anhedonia, the loss of enjoyment in activities, a core feature of depression. The findings may explain why depression is more prevalent in women than in men.... Read More...

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Differences in brain activity in children with anhedonia

Neuroscience NewsMarch 13, 2019

Using fMRI to examine the brains of children while resting, researchers discover anhedonia is associated with hyperconnectivity between the cingulo-opercular network and ventral striatum.... Read More...

FeaturedNeuroscience6 min read

New Insights Into Loss of Pleasure in Depression

Neuroscience NewsDecember 4, 2018

A new study reveals a brain region that contributes to anhedonia, the loss of pleasure, in those with depression. The study also shows how ketamine acts on this brain region, explaining why the drug appears to be so effective at treating anhedonia.... Read More...

FeaturedNeuroscienceOpen Neuroscience ArticlesPsychology7 min read

Personality and Mood Affect Brain Response to Personal Choice

Neuroscience NewsNovember 20, 2018

Researchers report personality traits and psychological health impact how we value personal control when making decisions. The study reports brain activity in the motivation system is dampened in those with passive personalities and depression when we receive rewards that we have earned or feel in personal control of situations.... Read More...

FeaturedNeuroscienceOpen Neuroscience ArticlesPsychology5 min read

Could Cognitive Interventions be Useful in Treating Depression?

Neuroscience NewsDecember 18, 2017

Researchers report cognitive bias modification may be a useful method for treating depression.... Read More...

FeaturedOpen Neuroscience ArticlesPsychology7 min read

People with Anhedonia Do Experience Pleasure, Just Not As Often

Neuroscience NewsDecember 9, 2017

It is possible for those with anhedonia to enjoy experiences and feel pleasure, however, those with the disorder find it hard to maintain their positive emotions, a new study reports.... Read More...

FeaturedPsychology3 min read

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anhedonia

Promising steps towards hope for a treatment for schizophrenia

Molecular link between chronic pain and depression revealed

Brain circuit connects feeding and mood in response to stress

Genetic variation contributes to individual differences in pleasure

New therapeutic target for depression identified

Inflammation induces anhedonia in women but not men

Differences in brain activity in children with anhedonia

New Insights Into Loss of Pleasure in Depression

Personality and Mood Affect Brain Response to Personal Choice

Could Cognitive Interventions be Useful in Treating Depression?

People with Anhedonia Do Experience Pleasure, Just Not As Often