anhedonia Research Articles - Neuroscience News

What people who don’t like music might tell us about social interaction

Neuroscience NewsJanuary 18, 2020

Musical anhedonia, a neurological condition where people don't enjoy music, affects 5% of the population. Researchers are exploring if this same condition could also be what impairs social bonding for some people on the autism spectrum.... Read More...

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Music helps researchers find link between prediction and pleasure

Neuroscience NewsJanuary 18, 2020

Exposing subjects to music composed in an unfamiliar scale, researchers test whether reward can be derived solely from newly formed predictions.... Read More...

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This is a chemical stick and ball model of dopamine

Dopamine fasting: an expert reviews the latest craze in Silicon Valley

Neuroscience NewsDecember 27, 2019

The latest Silicon Valley crazy of dopamine fasting promises to "reset" the brain to be more effective and appreciate the smaller things in life more easily, but does it work? Researchers look at the effect of dopamine fasting on brain health.... Read More...

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Why stress doesn’t always cause depression

Neuroscience NewsDecember 2, 2019

Rats susceptible to anhedonia have more serotonin neurons in the ventral dorsal raphe nucleus. However, activating neurons in the central amygdala reduced the serotonin signaling and lowered the effects of social stress.... Read More...

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Promising steps towards hope for a treatment for schizophrenia

Neuroscience NewsOctober 4, 2019

Mu-opioid receptor (MOR) levels are significantly reduced in the striatum in those with schizophrenia. A lack of MOR system stimulation contributes to negative feelings, such as a lack of motivation and anhedonia, associated with the condition. Increasing MOR levels could help to reduce some of the symptoms of schizophrenia.... Read More...

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Molecular link between chronic pain and depression revealed

Neuroscience NewsSeptember 26, 2019

Inhibitory inputs to the neural circuit between the dorsolateral bed nucleus of the stria terminalis (dlBNST) to the ventral tegmental area (VTA) increase when a person is in chronic pain. This alteration is mediated by enhanced corticotropin-releasing factor signaling within the dlBNST, leading to suppression of the mesolimbic dopaminergic system. The result is depressive mood and anhedonia associated with chronic pain.... Read More...

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Brain circuit connects feeding and mood in response to stress

Neuroscience NewsSeptember 5, 2019

A new study identifies a novel neural network regulating feeding and mood in response to chronic stress. Inhibiting the POMC to ventral tegmental area circuit increases body weight and food intake while reducing depressive symptoms in mouse models.... Read More...

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Genetic variation contributes to individual differences in pleasure

Neuroscience NewsAugust 8, 2019

What we find pleasurable may be down to our genetics. Researchers found nucleus accumbens activation and physical anhedonia were influenced by shared genes. The experience of pleasure and physical anhedonia also appear to share some of the same genes.... Read More...

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New therapeutic target for depression identified

Neuroscience NewsMay 22, 2019

A fragment of the neuropeptide Galanin appears to play a role in anhedonia in mouse models of depression. Galanin could be a potential target for the treatment of depression.... Read More...

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Inflammation induces anhedonia in women but not men

Neuroscience NewsMay 15, 2019

Inflammation appears to reduce reward response in females. Reduced activity in the brain's reward system is a key component of anhedonia, the loss of enjoyment in activities, a core feature of depression. The findings may explain why depression is more prevalent in women than in men.... Read More...

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Differences in brain activity in children with anhedonia

Neuroscience NewsMarch 13, 2019

Using fMRI to examine the brains of children while resting, researchers discover anhedonia is associated with hyperconnectivity between the cingulo-opercular network and ventral striatum.... Read More...

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New Insights Into Loss of Pleasure in Depression

Neuroscience NewsDecember 4, 2018

A new study reveals a brain region that contributes to anhedonia, the loss of pleasure, in those with depression. The study also shows how ketamine acts on this brain region, explaining why the drug appears to be so effective at treating anhedonia.... Read More...

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anhedonia

Music helps researchers find link between prediction and pleasure

Dopamine fasting: an expert reviews the latest craze in Silicon Valley

Promising steps towards hope for a treatment for schizophrenia

Molecular link between chronic pain and depression revealed

Brain circuit connects feeding and mood in response to stress

Genetic variation contributes to individual differences in pleasure

New therapeutic target for depression identified

Inflammation induces anhedonia in women but not men

Differences in brain activity in children with anhedonia

New Insights Into Loss of Pleasure in Depression