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AMPA

·November 30, 2022·7 min read

Silent Synapses Are Abundant in the Adult Brain

The adult brain contains millions of "silent synapses", or immature connections between neurons that remain inactive until they are required for learning new information and storing new memories.

Featured Neuroscience Open Neuroscience Articles Psychology

·August 11, 2021·4 min read

New Findings on How Ketamine Prevents Depression

A new study provides novel mechanistic insights into how ketamine exerts its antidepressant effects for those with depression.

Electrophysiology Featured Neuroscience

·October 1, 2020·3 min read

Why Drugs Sometimes Cause Receptor Potentiation Rather Than Inhibition

Receptor potentiation was observed when the antagonists bind to receptors that consist of different subunits, where it acts as a subunit.

This shows how the protein acts at the synapse

Featured Neurology Neuroscience

·August 28, 2020·4 min read

A Tailor-Made Molecule That Ties Nerve Connections

A newly designed synthetic compound could act as a prototype for a novel class of drugs to treat neurological damage.

Featured Neurology

·July 20, 2020·4 min read

Oxytocin Could Be Used to Treat Cognitive Disorders Like Alzheimer’s

Oxytocin, the so-called "love hormone," could help to treat cognitive disorders, including Alzheimer's disease. Researchers demonstrated oxytocin reversed the effects of amyloid-beta on hippocampal LTP in mice. The findings suggest oxytocin could be used as a therapeutic for the treatment of Alzheimer's disease and other dementias.

Featured Neuroscience Open Neuroscience Articles

·February 3, 2020·4 min read

Early life experiences biologically and functionally mature the brain

Learning and memory abilities may vary, depending on the nature of individual experiences early in life.

Featured Neuroscience

·January 2, 2020·4 min read

Some learning is a whole-brain affair

Motor learning induces widespread cortical synaptic potentiation by increasing the trafficking of AMPAR into dendritic spines.

Featured Neuroscience Open Neuroscience Articles

·November 20, 2019·3 min read

Shining a light on synaptic plasticity

AMPA receptors form and disintegrate continually, rather than existing as stable entities. The findings shed light on the early stages of synaptic plasticity.

Featured Neurology Open Neuroscience Articles

·January 7, 2019·4 min read

New Key Mechanism of Epileptic Seizures Revealed

According to a new mathematical model of seizures, only the conductivity of the AMPA receptors in neurons in the temporal lobe significantly change, leading to stronger excitation and synaptic signals.

Featured Neuroscience

·December 19, 2018·4 min read

GABA Cells Help Fight Alcoholism

Researchers have identified how alcohol influences dopaminergic and inhibitory neurons in the ventral tegmental area. The findings could help develop new treatments for alcohol dependence.