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Alzheimer’s disease

·November 26, 2024·3 min read

Alzheimer’s Drug Shrinks Brain Volume by Removing Amyloid Plaques

Brain volume loss linked to new Alzheimer’s immunotherapies, such as lecanemab, is caused by the removal of amyloid plaques rather than neuronal damage. Researchers analyzed data from multiple trials and coined the term "amyloid-removal-related pseudo-atrophy" (ARPA) to describe this phenomenon.

Featured Genetics Neurology Neuroscience

·November 21, 2024·5 min read

Maternal Inflammation May Shape Offspring’s Alzheimer’s Risk

Maternal immune activity during pregnancy influences memory circuitry in offspring, with sex-specific effects extending into midlife. Elevated immune markers like IL-6 and TNF-a in mothers were linked to adverse brain activity in memory regions, particularly in postmenopausal women, and lower cognitive performance in children.

Featured Neurology Neuroscience

·November 20, 2024·3 min read

Earpiece Tech Detects Early Alzheimer’s Through Eye Movement Signals

Researchers are exploring how earpiece microphones, or "hearables," could detect early signs of Alzheimer’s disease by monitoring subtle eye movement changes. Alzheimer’s impacts motor and cognitive functions, with slowed or delayed eye movements (saccades) being an early indicator.

Featured Neurology Neuroscience

·November 19, 2024·5 min read

Early-Onset Diabetes Linked to Increased Dementia Risk

New research reveals that individuals diagnosed with type 2 diabetes at a younger age face a higher risk of developing dementia, particularly those with obesity. The study found that for each year earlier type 2 diabetes is diagnosed, dementia risk increases by 1.9%.

This shows a researcher holding a card with blood on it, a brain is in the background.

Featured Neurology Neuroscience

·November 18, 2024·3 min read

Finger-Prick Test Brings Alzheimer’s Detection Closer to Everyone

A new Alzheimer’s test collects just a few drops of blood from a finger prick, which can be mailed to a lab for analysis. The test measures biomarkers like pTau217 and has shown similar accuracy to traditional venous blood sampling.

Featured Genetics Neurology Neuroscience

·November 18, 2024·4 min read

Unique Brain Plaques Linked to Alzheimer’s Mutation Decoded

Researchers have identified the structure of amyloid beta fibrils linked to a rare inherited form of Alzheimer’s disease caused by the Arctic mutation. Using cryo-electron microscopy and NMR, they revealed a W-shaped fibril structure that explains the formation of cottonwool plaques—large, spherical brain structures unique to this mutation.

Featured Genetics Neurology Neuroscience

·November 16, 2024·8 min read

Alzheimer’s Linked to Key Proteins via Cerebrospinal Fluid Analysis

Using cerebrospinal fluid from living patients, researchers have identified specific proteins and genetic pathways involved in the development and progression of Alzheimer’s disease. This proteomic analysis revealed 38 proteins likely to play causal roles in Alzheimer’s, 15 of which are potential drug targets.

Featured Neurology Neuroscience

·November 12, 2024·5 min read

Frailty Boosts Dementia Risk

Frailty is a strong predictor of dementia risk, with risk increasing by 40% with each 4-5 additional age-related health conditions. This connection between frailty and dementia suggests that frailty may not simply result from undetected dementia but actively contributes to its onset.

Featured Neurology Neuroscience

·November 11, 2024·6 min read

Fluctuating Cholesterol Linked to Higher Dementia Risk

Older adults with significant fluctuations in cholesterol levels are at increased risk for dementia and cognitive decline, even without medication changes. Researchers studied nearly 10,000 older adults, tracking their cholesterol levels and cognitive function over six years. High variability in total and LDL ("bad") cholesterol was associated with a 60% increase in dementia and 23% increase in cognitive decline.

Featured Genetics Neurology Neuroscience

·November 11, 2024·4 min read

Targeting Enzyme TYK2 Could Reduce Tau in Alzheimer’s Disease

Scientists have discovered that the enzyme TYK2 modifies tau proteins, leading to their accumulation in the brain—a key feature of Alzheimer’s disease and related dementias. By reducing TYK2 activity in animal models, researchers found tau buildup was decreased, suggesting TYK2 inhibitors could be a potential therapeutic pathway.

Featured Neurology Neuroscience

·November 7, 2024·4 min read

New Nasal Spray Could Delay Alzheimer’s Progression by Years

Researchers have developed a promising nasal spray therapy targeting neuroinflammation in Alzheimer’s disease, potentially delaying its progression by over a decade. Using extracellular vesicles derived from neural stem cells, the treatment reduced inflammation and protein build-up in the brain in early-stage Alzheimer’s animal models.

This shows a man's face and broken bottles.

Featured Genetics Neurology Neuroscience

·November 5, 2024·5 min read

Gene Study Links Alcohol Addiction to Accelerated Alzheimer’s Progression

Researchers discovered alcohol use disorder (AUD) and Alzheimer's disease (AD) exhibit similar patterns of gene dysregulation, hinting that alcohol consumption may hasten Alzheimer’s progression. By analyzing gene expression across individual brain cells, the team found shared disruptions in inflammation, cell signaling, and blood vessel functions in both disorders.

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Alzheimer’s disease

Alzheimer’s Drug Shrinks Brain Volume by Removing Amyloid Plaques

Maternal Inflammation May Shape Offspring’s Alzheimer’s Risk

Earpiece Tech Detects Early Alzheimer’s Through Eye Movement Signals

Early-Onset Diabetes Linked to Increased Dementia Risk

Finger-Prick Test Brings Alzheimer’s Detection Closer to Everyone

Unique Brain Plaques Linked to Alzheimer’s Mutation Decoded

Alzheimer’s Linked to Key Proteins via Cerebrospinal Fluid Analysis

Frailty Boosts Dementia Risk

Fluctuating Cholesterol Linked to Higher Dementia Risk

Targeting Enzyme TYK2 Could Reduce Tau in Alzheimer’s Disease

New Nasal Spray Could Delay Alzheimer’s Progression by Years

Gene Study Links Alcohol Addiction to Accelerated Alzheimer’s Progression

When Do Kids Start Creating Original Sentences? AI Pinpoints the Age

How Memories Shape Decisions and Future Well-Being

Alzheimer’s Drug Shrinks Brain Volume by Removing Amyloid Plaques

Fitness Trackers Detect Mood Episodes in Bipolar Disorder with High Accuracy

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