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          Alzheimer’s disease

          This shows a brain.
          FeaturedGeneticsNeurologyNeuroscience
          ·June 24, 2025·5 min read

          Rare Mutation Shields Brain from Alzheimer’s by Silencing Inflammation

          A rare genetic mutation known as APOE3-R136S, or the “Christchurch mutation,” appears to protect against Alzheimer’s disease by suppressing inflammatory signaling in the brain’s immune cells. Researchers found that this mutation dampens the cGAS-STING pathway, a key innate immune mechanism that is abnormally activated in Alzheimer’s and other neurodegenerative disorders.
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          This shows a group of people.
          FeaturedNeurologyNeuroscience
          ·June 18, 2025·3 min read

          Alzheimer’s Risk Linked to Increased Social Activity, Not Isolation

          Contrary to popular belief, a new study suggests that people with a higher genetic risk for Alzheimer’s may become more socially engaged—not less. Researchers analyzed data from over 500,000 individuals and found that higher-risk participants reported lower social isolation and more positive family interactions.
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          This shows a person on a treadmill and neurons.
          FeaturedGeneticsNeurologyNeuroscience
          ·June 13, 2025·5 min read

          Exercise Rewires Alzheimer’s-Affected Brain Cells

          Using cutting-edge RNA sequencing, researchers mapped how exercise affects specific brain cell types in a model of Alzheimer’s disease. They found that physical activity alters gene activity in microglia and a newly identified type of astrocyte linked to blood vessels, which may protect memory.
          Read More
          This shows DNA.
          FeaturedGeneticsNeurologyNeuroscience
          ·June 11, 2025·7 min read

          New Map Reveals First Steps of Protein Clumping in Alzheimer’s

          Scientists have mapped how over 140,000 mutations affect the formation of amyloid beta fibrils, offering an unprecedented look at early events in Alzheimer’s disease. By combining DNA synthesis, genetically engineered yeast, and machine learning, they built a detailed energy landscape of the protein’s transition state—an elusive moment before plaque formation begins.
          Read More
          This shows an older woman and a brain.
          FeaturedNeurologyNeurosciencePsychology
          ·June 10, 2025·5 min read

          Late-Life Mood Disorders May Foreshadow Alzheimer’s

          Late-life depression and bipolar disorder may be more than psychiatric conditions—they could be early warning signs of neurodegenerative diseases like Alzheimer’s. Using advanced brain imaging and postmortem tissue analysis, researchers found that half of the participants with late-onset mood disorders showed signs of tau accumulation, a key hallmark of neurodegeneration.
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          This shows a brain, DNA, and pills.
          FeaturedGeneticsNeurologyNeuroscience
          ·June 5, 2025·7 min read

          HIV Drugs Linked to Lower Alzheimer’s Risk

          FDA-approved HIV drugs targeting reverse transcriptase (RT) may reduce Alzheimer’s risk by blocking similar enzymatic activity in the aging brain. Scientists discovered unexpected RT activity in neurons of healthy and Alzheimer’s brains, tracing it to truncated LINE1 elements—ancient genetic sequences capable of copying themselves via RT.
          Read More
          This shows a brain.
          FeaturedGeneticsNeurologyNeuroscience
          ·June 2, 2025·6 min read

          Blocking Brain Inflammation Molecule May Halt Alzheimer’s

          A new study has uncovered a surprising culprit in the progression of Alzheimer’s disease: the immune molecule STING. Scientists found that STING, normally involved in defending the brain, becomes hyperactive with age, causing harmful inflammation and accelerating brain damage.
          Read More
          This shows a brain.
          FeaturedNeurologyNeuroscience
          ·May 30, 2025·4 min read

          SSRIs Restore Brain Function in Alzheimer’s

          A new study suggests that SSRIs, commonly prescribed antidepressants, may reduce biological markers of Alzheimer’s disease. In a cohort of 191 individuals, AD patients on SSRIs had lower levels of plasma phosphorylated tau-181, a key indicator of disease severity.
          Read More
          This shows a man, a woman, DNA, and a brain.
          FeaturedGeneticsNeurologyNeuroscience
          ·May 30, 2025·5 min read

          Common Gene Variant Doubles Dementia Risk, But Only in Men

          New research reveals that men who carry two copies of a common genetic variant in the HFE gene are more than twice as likely to develop dementia, while women with the same variant are not affected. The variant, known as H63D, is linked to haemochromatosis and is present in about 1 in 36 people.
          Read More
          This shows a person sleeping.
          FeaturedNeurologyNeuroscience
          ·May 29, 2025·6 min read

          Sleep Aid May Protect Brain from Alzheimer’s Damage

          A common sleep medication, lemborexant, may do more than promote rest—it appears to reduce harmful tau buildup and protect the brain from neurodegeneration in mouse models of Alzheimer’s disease. Researchers found that this orexin receptor antagonist not only restored healthier sleep patterns but also preserved brain structure and reduced inflammation.
          Read More
          This shows an older woman's hands.
          FeaturedNeurologyNeuroscience
          ·May 25, 2025·4 min read

          Dementia Diagnoses Decline, But More Are Living Longer With the Disease

          A new study of over 25 million Medicare recipients found that while dementia incidence in the U.S. is declining, more older adults are living longer with the condition. From 2015 to 2021, new diagnoses dropped from 3.5% to 2.8%, yet prevalence increased to nearly 12%.
          Read More
          This shows a brain.
          FeaturedNeurologyNeuroscience
          ·May 21, 2025·4 min read

          New Alzheimer’s Drug Boosts Brain Protection, Restores Memory

          Researchers have identified a promising drug candidate, DDL-357, that improves memory in Alzheimer’s mouse models by increasing levels of a protective brain protein called clusterin (CLU). CLU helps prevent the buildup of toxic amyloid-beta plaques and tau proteins, both key drivers of Alzheimer’s disease.
          Read More
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          • Chimpanzees and Children Share a Curiosity for Social Drama
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          • Rare Mutation Shields Brain from Alzheimer’s by Silencing Inflammation
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          This shows a chimp and a child on cell phones.

          Chimpanzees and Children Share a Curiosity for Social Drama

          This shows a person holding their head in pain.

          GLP-1 Drug Cuts Migraine Days in Half

          This shows a skull and a brain.

          PET Imaging Maps Brain Inflammation in Progressive Speech Disorder

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          Older Motherhood Linked to Higher Birth Risks, Especially After 45

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