Summary: According to researchers, dopamine signaling within the cerebral cortex can predict changes between neural networks during working memory tasks.
Source: Mass General.
Understanding the relation of dopamine to network activity could improve schizophrenia treatment.
How does the cross-talk between brain networks change when working memory – the mental assembly of information needed to carry out a particular task — is engaged? Investigators at Massachusetts General Hospital (MGH) have found that dopamine signaling within the cerebral cortex can predict changes in the extent of communication between key brain networks during working memory. Their findings receiving online publication in Science Advances may lay the groundwork for studies of how disruptions in dopamine signaling contribute to working memory deficits that are characteristic of schizophrenia and other psychiatric disorders.
“Our principal finding is that dopamine signaling within the cortex predicts the extent to which the frontoparietal control network — which directly mediates working memory performance — becomes disconnected from the default network – which is active when the brain is awake but directed towards internal tasks, such as thinking about past or future events,” says Joshua Roffman, MD, of the MGH Department of Psychiatry, lead and corresponding author of the paper. “The disengagement of these two networks is what allows us to shift our focus away from internal events and towards the performance of many types of cognitive tasks.”
For their investigation the MGH team utilized the first device capable of simultaneous MRI and PET imaging, which is located at the Martinos Center for Biomedical Imaging at MGH. The ability to conduct both scans at the same time allows real-time measurement of both dopamine signaling — using a PET imaging agent that binds to D1 dopamine receptors – and the interaction of particular brain networks, as measured by functional MRI.
After first confirming that connection between the frontoparietal control network and the default network abruptly drops when healthy volunteers begin engaging in a working memory task, the researchers then showed that the disengagement between the two networks was strongest in individuals with the lowest cortical density of D1 receptors, which reflects higher dopamine levels. D1 receptor density did not affect how accurately study participants completed the memory task.
An associate professor of Psychiatry at Harvard Medical School, Roffman notes that this result is in line with previous studies in primate models showing that dopamine signaling on a cellular level is essential to a key aspect of working memory – determining which neural signals to pay attention to and which to ignore. This study is the first to examine how this cellular-level activity is expanded to a network-wide level in the brains of healthy humans. He states, “We hope that improved understanding of the role of dopamine in organizing cortical networks will lead us to better ways of improving working memory in patients with schizophrenia and other illnesses through optimized dopamine signaling.”
Co-authors of the Science Advances report are Alexandra Tanner, Hamdi Eryilmaz, PhD, Anais Rodriguez-Thompson, Noah J. Silverstein, New Fei Ho, PhD, Adam Z. Nitenson, Randy Buckner, PhD, and Dara Manoach, PhD, MGH Psychiatry; Daniel Chonde, Douglas Greve, PhD, Bruce Rosen, MD, PhD, Jacob Hooker, PhD, and Ciprian Catana, MD, Martinos Center; and Anissa Abi-Dargham, MD, Columbia University Medical Center.
Funding: Support for the study includes a Howard Hughes Medical Institute Early Career Physician-Scientist Award and National Institutes of Health grant R01 MH101425.
Source: Noah Brown – Mass General
Image Source: This NeuroscienceNews.com image is credited to Joshua Roffman and Hamdi Eryilmaz, Massachusetts General Hospital Department of Psychiatry.
Original Research: Abstract for “Dopamine D1 signaling organizes network dynamics underlying working memory” by Joshua L. Roffman, Alexandra S. Tanner, Hamdi Eryilmaz, Anais Rodriguez-Thompson, Noah J. Silverstein, New Fei Ho, Adam Z. Nitenson, Daniel B. Chonde, Douglas N. Greve, Anissa Abi-Dargham, Randy L. Buckner, Dara S. Manoach, Bruce R. Rosen, Jacob M. Hooker and Ciprian Catana in Science Advances. Published online June 3 3016 doi:10.1126/sciadv.1501672
Dopamine D1 signaling organizes network dynamics underlying working memory
Local prefrontal dopamine signaling supports working memory by tuning pyramidal neurons to task-relevant stimuli. Enabled by simultaneous positron emission tomography–magnetic resonance imaging (PET-MRI), we determined whether neuromodulatory effects of dopamine scale to the level of cortical networks and coordinate their interplay during working memory. Among network territories, mean cortical D1 receptor densities differed substantially but were strongly interrelated, suggesting cross-network regulation. Indeed, mean cortical D1 density predicted working memory–emergent decoupling of the frontoparietal and default networks, which respectively manage task-related and internal stimuli. In contrast, striatal D1 predicted opposing effects within these two networks but no between-network effects. These findings specifically link cortical dopamine signaling to network crosstalk that redirects cognitive resources to working memory, echoing neuromodulatory effects of D1 signaling on the level of cortical microcircuits.
“Dopamine D1 signaling organizes network dynamics underlying working memory” by Joshua L. Roffman, Alexandra S. Tanner, Hamdi Eryilmaz, Anais Rodriguez-Thompson, Noah J. Silverstein, New Fei Ho, Adam Z. Nitenson, Daniel B. Chonde, Douglas N. Greve, Anissa Abi-Dargham, Randy L. Buckner, Dara S. Manoach, Bruce R. Rosen, Jacob M. Hooker and Ciprian Catana in Science Advances. Published online June 3 3016 doi:10.1126/sciadv.1501672