A password will be e-mailed to you.

Molecular Basis of Touch Sensation

MDC researchers identify new function of a well-known gene

A gene known to control lens development in mice and humans is also crucial for the development of neurons responsible for mechanosensory function, as neurobiologists of the Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch have now discovered.

They found that in mice in which they had removed the c-Maf gene in the nerve cells, touch sensation is impaired. This similarly applies to human carriers of a mutant c-Maf gene. People with such a mutation suffer already at a young age from cataracts, a clouding of the lens which typically affects the elderly.

The patients, as demonstrated by Professor Carmen Birchmeier and Dr. Hagen Wende in collaboration with Professor Gary Lewin and Dr. Stefan Lechner, have difficulty holding objects such as a sheet of paper as a consequence of this mutation. (Science Express, 16 February 2012 / Page 1 / 10.1126/science.1214314)*.

Professor Birchmeier, a developmental biologist, commented on the findings of her research group: “c-Maf is an important gene for the development of the peripheral nerve cells.” The gene controls the development of neurons that detect touch, the mechanosensory neurons. Previously, c-Maf was known as a key regulator of lens development.

Furthermore, the gene is also active in the dorsal root ganglia, an aggregate of nerve cells next to the spinal cord in which the cell bodies of mechanosensory neurons are localized. The nerve cells form long axons, which terminate in the skin in touch corpuscles or at hair shafts. These axons detect mechanical stimuli, which in turn are converted into electrical signals and transmitted to the brain. When you stroke your fingers over a surface, its structure triggers high-frequency vibrations in the finger, to which specific touch receptors, the Pacinian corpuscles, respond.

In mice with deactivated c-Maf gene only few Pacinian corpuscles are formed, and moreover these few are not intact. The mice are therefore unable to recognize high-frequency vibrations. The same is true for a Swiss family with an inherited mutant c-Maf gene. The consequence is that the affected patients develop cataracts at an early age and have an impaired sense of touch.

Notes about this neuroscience research article

Contact: Barbara Bachtler – Max Delbrück Center for Molecular Medicine (MDC) Berlin-Buch
in the Helmholtz Association

Source: Helmholtz Association of German Research Centres press release
Image Source: Neuroscience image adapted from press release image with credit to Hagen Wende/Copyright: MDC.
Original Research: Abstract for “The transcription factor c-Maf controls touch receptor development and function” by Hagen Wende, Stefan G. Lechner, Cyril Cheret, Steeve Bourane, Maria E. Kolanczyk, Alexandre Pattyn, Katja Reuter, Francis L. Munier, Patrick Carroll, Gary R. Lewin and Carmen Birchmeier in Science Express

A hair follicle is shown with neurons surrounding it.

Mechanosensory endings of nerve cells in the skin detect touch stimuli. Here various nerve endings (red and green) nestle around the shaft of a hair (grey, fibrous structure), which is anchored in a hair follicle. The nerve endings are stimulated by movements of the hair. The mechanical stimulus is converted into electrical signals which are transmitted to the brain. (Photo: Hagen Wende/Copyright: MDC) Click photo for original view and dimensions.

Join our Newsletter
I agree to have my personal information transferred to AWeber for Neuroscience Newsletter ( more information )
Sign up to receive the latest neuroscience headlines and summaries sent to your email daily from NeuroscienceNews.com
We hate spam and only use your email to contact you about newsletters. We do not sell email addresses. You can cancel your subscription any time.
No more articles