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Machine Learning Helps Predict Treatment Outcomes in Schizophrenia

Summary: A machine learning algorithm is able to successfully identify, with 78% accuracy, schizophrenia in patients based on brain scans of the superior temporal cortex. The algorithm is also 82% accurate in predicting whether or not a patient will respond positively to a specific antipsychotic medication.

Source: University of Alberta.

Could the diagnosis and treatment of mental health disorders one day be aided through the help of machine learning? New research from the University of Alberta is bringing us closer to that future through a study published in Molecular Psychiatry.

The research was led by Bo Cao at the U of A’s Department of Psychiatry, with the collaboration of Xiang Yang Zhang at the University of Texas Health Science Center at Houston. They used a machine-learning algorithm to examine functional magnetic resonance imaging (MRI) images of both newly diagnosed, previously untreated schizophrenia patients and healthy subjects. By measuring the connections of a brain region called the superior temporal cortex to other regions of the brain, the algorithm successfully identified patients with schizophrenia at 78 per cent accuracy. It also predicted with 82 per cent accuracy whether or not a patient would respond positively to a specific antipsychotic treatment named risperidone.

“This is the first step, but ultimately we hope to find reliable biomarkers that can predict schizophrenia before the symptoms show up,” said Cao, an assistant professor of psychiatry at the U of A. “We also want to use machine learning to optimize a patient’s treatment plan. It wouldn’t replace the doctor. In the future, with the help of machine learning, if the doctor can select the best medicine or procedure for a specific patient at the first visit, it would be a good step forward.”

Approximately one in 100 people will be affected by schizophrenia at some point in their lives, a severe and disabling psychiatric disorder that comes with delusions, hallucinations and cognitive impairments. Most patients with schizophrenia develop the symptoms early in life and will struggle with them for decades.

a computerized brain

Approximately one in 100 people will be affected by schizophrenia at some point in their lives, a severe and disabling psychiatric disorder that comes with delusions, hallucinations and cognitive impairments. Most patients with schizophrenia develop the symptoms early in life and will struggle with them for decades. NeuroscienceNews.com image is in the public domain.

According to Cao, early diagnosis of schizophrenia and many mental disorders is an ongoing challenge. Coming up with the personalized treatment strategy at the first visit with a patient is also a challenge for clinicians. Current treatment of schizophrenia is still often determined by a trial-and-error style. If a drug is not working properly, the patient may suffer prolonged symptoms and side effects, and miss the best time window to get the disease controlled and treated.

Cao hopes to expand the work to include other mental illness such as major depressive and bipolar disorders. While the initial results of schizophrenia diagnosis and treatment are encouraging, Cao says that further validations on large samples will be necessary and more refinement is needed to increase accuracy before the work can be translated into a useful tool in a clinical environment.

“It will be a joint effort of the patients, psychiatrists, neuroscientists, computer scientists and researchers in other disciplines to build better tools for precise mental health,” said Cao. “We have a Computational Psychiatry group at U of A with a team of excellent clinicians and scientists to work collaboratively on this challenging problem.”

About this neuroscience research article

Funding: The study was funded by the Brain and Behavior Research Foundation.

Source: Shelby Soke – University of Alberta
Publisher: Organized by NeuroscienceNews.com.
Image Source: NeuroscienceNews.com image is in the public domain.
Original Research: Abstract for “Treatment response prediction and individualized identification of first-episode drug-naïve schizophrenia using brain functional connectivity” by Bo Cao, Raymond Y. Cho, Dachun Chen, Meihong Xiu, Li Wang, Jair C. Soares & Xiang Yang Zhang in Molecular Psychiatry. Published June 19 2018.
doi:10.1038/s41380-018-0106-5

Cite This NeuroscienceNews.com Article
University of Alberta”Machine Learning Helps Predict Treatment Outcomes in Schizophrenia.” NeuroscienceNews. NeuroscienceNews, 12 July 2018.
<http://neurosciencenews.com/machine-learning-schizophrenia-9562/>.
University of Alberta(2018, July 12). Machine Learning Helps Predict Treatment Outcomes in Schizophrenia. NeuroscienceNews. Retrieved July 12, 2018 from http://neurosciencenews.com/machine-learning-schizophrenia-9562/
University of Alberta”Machine Learning Helps Predict Treatment Outcomes in Schizophrenia.” http://neurosciencenews.com/machine-learning-schizophrenia-9562/ (accessed July 12, 2018).

Abstract

Treatment response prediction and individualized identification of first-episode drug-naïve schizophrenia using brain functional connectivity

Identifying biomarkers in schizophrenia during the first episode without the confounding effects of treatment has been challenging. Leveraging these biomarkers to establish diagnosis and make individualized predictions of future treatment responses to antipsychotics would be of great value, but there has been limited progress. In this study, by using machine learning algorithms and the functional connections of the superior temporal cortex, we successfully identified the first-episode drug-naive (FEDN) schizophrenia patients (accuracy 78.6%) and predict their responses to antipsychotic treatment (accuracy 82.5%) at an individual level. The functional connections (FC) were derived using the mutual information and the correlations, between the blood-oxygen-level dependent signals of the superior temporal cortex and other cortical regions acquired with the resting-state functional magnetic resonance imaging. We also found that the mutual information and correlation FC was informative in identifying individual FEDN schizophrenia and prediction of treatment response, respectively. The methods and findings in this paper could provide a critical step toward individualized identification and treatment response prediction in first-episode drug-naive schizophrenia, which could complement other biomarkers in the development of precision medicine approaches for this severe mental disorder.

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