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psychopharmacology

·November 6, 2025·6 min read

New Drug Exposes Hidden Subtypes of Psychosis

A new study examining real-world hospital data reveals early indicators of who is most likely to benefit from Cobenfy, the first new schizophrenia drug mechanism approved in 50 years. Patients with strong negative symptoms responded best to the xanomeline–trospium combination, showing notable improvements in social behavior and mood.

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·November 5, 2025·6 min read

Antibiotic Doxycycline May Cut Schizophrenia Risk

A large population-based study suggests that doxycycline, a common antibiotic, may reduce the risk of schizophrenia when prescribed to adolescents receiving mental health care. Researchers analyzed data from more than 56,000 young patients and found that those who took doxycycline had a 30–35% lower chance of developing schizophrenia later in life.

Featured Neuroscience Psychology

·October 30, 2025·6 min read

Common Antidepressant Eases Core Symptoms Within Two Weeks

A new analysis of the PANDA clinical trial reveals that sertraline, one of the most prescribed antidepressants, improves key emotional symptoms of depression—such as sadness, self-loathing, and suicidal thoughts—within just two weeks of treatment. Using network analysis to assess individual symptoms, researchers found that the drug also eased anxiety early on, while somatic effects like fatigue and low libido appeared but later stabilized.

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·October 27, 2025·4 min read

Psychedelics May Rewire Memory Circuits Key to Mental Health

New research suggests that psychedelic drugs may work by strengthening specific brain connections linked to memory and cognition. Scientists found that under psychedelic exposure, neurons in the claustrum—a region dense with psychedelic-sensitive receptors—intensified their communication with the anterior cingulate cortex, a region involved in mood and psychiatric disorders.

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·October 22, 2025·8 min read

Ketamine Fails to Outperform Placebo in Major Depression Trial

A large randomized and blinded clinical trial has found no additional benefit of repeated ketamine infusions over standard inpatient care for treating major depression. The study compared ketamine with a psychoactive placebo and found no meaningful differences in objective or self-reported depression scores, cognition, or quality of life.

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Featured Neuroscience Psychology

·October 13, 2025·6 min read

EEG Test May Reveal Who Loses Libido on Antidepressants

A new study reveals that serotonin levels in the brain, measured using a simple EEG-based test, can predict who will experience sexual side effects from SSRI antidepressants. Researchers found that people with higher serotonin activity before treatment were significantly more likely to have difficulty reaching orgasm during antidepressant use.

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·October 2, 2025·6 min read

Psilocybin Rewire Brain Circuits Tied to Pain and Mood

New research shows that psilocybin, the active compound in psychedelic mushrooms, can reduce both chronic pain and pain-related depression by modulating brain circuits rather than acting at the site of injury. In mouse studies, a single dose provided pain relief and mood benefits lasting nearly two weeks by targeting the anterior cingulate cortex.

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Featured Neuroscience Psychology

·September 30, 2025·7 min read

Psilocybin Worsens Postpartum Depression Symptoms

New research shows psilocybin, often studied as a treatment for mental health disorders, may worsen symptoms of postpartum depression in mice. Mothers given the drug showed more anxiety, avoidance of their pups, and lasting depressive-like behaviors.

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·September 17, 2025·4 min read

Psychedelics Show Promise for Healing Concussions and Brain Injuries

Traumatic brain injuries, including concussions, affect nearly 69 million people worldwide each year, yet treatments remain scarce. A new review highlights the potential of psychedelics such as psilocybin and 5-MeO-DMT to reduce harmful inflammation and enhance neuroplasticity after brain injury.

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·August 27, 2025·3 min read

Cannabis Linked to Reduced Insomnia and Anxiety

A new study suggests cannabis-based medical products may help people with insomnia sleep better over the long term. Across 124 patients followed for up to 18 months, participants consistently reported improved sleep quality, less anxiety and depression, and a better overall quality of life.

This is a visual representation of the 5-HT1A serotonin receptor.

Featured Neuroscience Psychology

·August 2, 2025·6 min read

Fat Molecule May Control How You Feel Emotion

Scientists have uncovered how the brain’s 5-HT1A serotonin receptor—vital in mood regulation—functions at the molecular level. This receptor, a common target of antidepressants and psychedelics, prefers certain signaling pathways no matter the drug, but drugs can still vary in how strongly they activate them.

Featured Neuroscience Psychology

·July 19, 2025·6 min read

More Than Serotonin: How Psychedelics Engage the Whole Brain

Classical psychedelics like LSD, psilocybin, and mescaline are known for activating the 5-HT2A serotonin receptor, but a new study reveals their effects go far beyond. Researchers profiled 41 psychedelics against over 300 human receptors and found potent activity at serotonin, dopamine, and adrenergic sites.

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psychopharmacology

New Drug Exposes Hidden Subtypes of Psychosis

Antibiotic Doxycycline May Cut Schizophrenia Risk

Common Antidepressant Eases Core Symptoms Within Two Weeks

Psychedelics May Rewire Memory Circuits Key to Mental Health

Ketamine Fails to Outperform Placebo in Major Depression Trial

EEG Test May Reveal Who Loses Libido on Antidepressants

Psilocybin Rewire Brain Circuits Tied to Pain and Mood

Psilocybin Worsens Postpartum Depression Symptoms

Psychedelics Show Promise for Healing Concussions and Brain Injuries

Cannabis Linked to Reduced Insomnia and Anxiety

Fat Molecule May Control How You Feel Emotion

More Than Serotonin: How Psychedelics Engage the Whole Brain

Touching Without Contact: We Physically Sense Objects Before Feeling Them

Nano Tech Helps CBD Quiet Pain at the Source

Adaptive Music Tech Makes Workouts More Fun, Helps People Stay Active

New Therapy Reshapes Images That Fuel Psychosis

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