SNRI antidepressants appear to be effective in the treatment of a range of pain conditions including neuropathic pain, fibromyalgia, and postoperative pain. Tricyclic antidepressants may not be effective in the treatment of pain.
Beta-blockers, a class of drugs commonly used to treat hypertension and cardiovascular disorders, appear to reduce aggressive and violent behaviors, and can reduce suicidal behaviors.
People who frequently take sleeping medications are 79% more likely to develop dementia than those who never use sleeping pills to aid their rest.
MAP4343, an experimental antidepressant compound reversed alcohol intake in rat models of alcohol use disorder. The findings pave the way for utilizing the compound for the treatment of AUD in humans.
Chronic pain in mice activates Tiam1 in pyramidal neurons in the anterior cingulate cortex, increasing the number of dendritic spines and inducing synaptic plasticity. Ketamine's antidepressant effect in chronic pain is mediated by the drug blocking Tiam1-dependent maladaptive synaptic plasticity in ACC neurons.
Levodopa, a drug commonly prescribed for the treatment of Parkinson's disease that increases dopamine in the brain was found to reverse the effects of neuroinflammation on the reward system and improve symptoms associated with depression.
SSRI antidepressants can make users less sensitive to rewards, resulting in emotional blunting many users experience. The findings provide new evidence for the role serotonin plays in reinforcement learning.
Taking SSRIs and having the "long-long" serotonin SERT genetic variant lowers SERT activity in the mitral valve, leading to degenerative mitral regurgitation, one of the most common heart valve diseases.
People who frequently visit green spaces are less likely to use prescription medications for anxiety, depression, high blood pressure, and asthma, a new study reports.
Diphenylbutylpiperidines (DPBPs), an older class of antipsychotic medications can effectively be repurposed to help treat type 2 diabetes, a new study reports.
Placebos can help reduce feelings of guilt, even when the placebo is given openly, a new study reports.
Often considered dangerous, mind-altering drugs, researchers are turning to the study of psychedelic therapies as a potential to treat an array of psychiatric conditions including depression and PTSD.
