From treating depression and other mental health disorders, to helping relieve chronic pain, researchers discuss the advantages and implications of psychedelic treatments.
Trihexyphenidyl, an anticholinergic medication commonly prescribed for Parkinson's symptoms, appears to alleviate negative memory flashbacks and nightmares experienced by those with PTSD.
One dose of psilocybin, the psychoactive compound found in magic mushrooms, increases dendritic spine density within 24 hours. The neurobiological changes lasted for a month following psilocybin exposure. Additionally, mice subjected to stress showed behavioral improvements and increased neurotransmitter activity after psilocybin exposure.
Lisdexamfetamine, a drug known to stimulate brain activity, reduces symptoms of sluggish cognitive tempo in adults with ADHD.
KNT-127 reduced anxiety-like behaviors in mice, researchers report.
Nitrous oxide, a common anesthesia most often associated with dental procedures, may have a new purpose. Researchers found a single inhalation of 25% nitrous oxide gas was effective at alleviating symptoms of depression in those with a treatment-resistant form of the mental health disorder.
A new study of male guppies reveals behaviors affected by methylphenidate hydrochloride (MPH), an active ingredient in common ADHD medications, can be passed along to future generations.
A new study reveals the molecular and cellular mechanisms behind why some people find it harder to stop using antidepressants than others with depression.
A single dose of tabernanthalog (TBG), a non-hallucinogenic psychedelic analog, corrects stress-induced behavioral deficits, including anxiety and cognitive inflexibility, in mouse models. Additionally, the compound promoted neurogenesis and restores neural circuits in brain areas damaged by stress.
Medications with anticholinergic properties given to help reduce physical and mental health symptoms associated with schizophrenia have a cumulative effect in reducing cognitive function in patients.
Flies without the Rim gene or cac Cav2 channel function displayed numerous cognitive and behavioral deficits associated with schizophrenia, and had reductions in synaptic growth and neural calcium transients. Exposing the flies with Rim deficits to the common antipsychotic haloperidol reduced some of the schizophrenia-related behavioral symptoms.
Osanetant, a drug that inhibits the Tac2 pathway, has opposite effects on the recall of traumatic events in male and female mice.
