Neuroscience research articles are provided.
What is neuroscience? Neuroscience is the scientific study of nervous systems. Neuroscience can involve research from many branches of science including those involving neurology, brain science, neurobiology, psychology, computer science, artificial intelligence, statistics, prosthetics, neuroimaging, engineering, medicine, physics, mathematics, pharmacology, electrophysiology, biology, robotics and technology.
– These articles focus mainly on neurology research. – What is neurology? – Definition of neurology: a science involved in the study of the nervous systems, especially of the diseases and disorders affecting them. – Neurology research can include information involving brain research, neurological disorders, medicine, brain cancer, peripheral nervous systems, central nervous systems, nerve damage, brain tumors, seizures, neurosurgery, electrophysiology, BMI, brain injuries, paralysis and spinal cord treatments.
What is Psychology? Definition of Psychology: Psychology is the study of behavior in an individual, or group. Psychology news articles are listed below.
Artificial Intelligence articles involve programming, neural engineering, artificial neural networks, artificial life, a-life, floyds, boids, emergence, machine learning, neuralbots, neuralrobotics, computational neuroscience and more involving A.I. research.
Robotics articles will cover robotics research press releases. Robotics news from universities, labs, researchers, engineers, students, high schools, conventions, competitions and more are posted and welcome.
Genetics articles related to neuroscience research will be listed here.
Neurotechnology research articles deal with robotics, AI, deep learning, machine learning, Brain Computer Interfaces, neuroprosthetics, neural implants and more. Read the latest neurotech news articles below.
Summary: Researchers combine functional connectivity analysis and network modeling to investigate synaptic mechanisms of pattern completion in hippocampal CA3 network.
Source: IST Austria.
Neuroscientists combine functional connectivity analysis and network modeling to investigate synaptic mechanisms of pattern completion in hippocampal CA3 network.
The hippocampal CA3 region plays a key role in learning and memory. One of the most remarkable properties of the network is its ability to retrieve previously stored memories from incomplete or degraded versions, a phenomenon that is widely known as pattern completion. It is generally accepted that the synapses between CA3 pyramidal cells, the recurrent CA3–CA3 synapses, play a key role in pattern completion, but how this exactly works has remained enigmatic. In a recent research article entitled “Synaptic mechanisms of pattern completion in the hippocampal CA3 network”, published on September 9, 2016, in Science, Jose Guzman, Alois Schlögl, Michael Frotscher, and Peter Jonas have investigated these mechanisms by combining functional connectivity analysis and network modeling. Their findings suggest that the rules of synaptic connectivity between CA3 pyramidal cells contribute to the remarkable efficiency of pattern completion.
Previous theories of the hippocampal formation often depicted the CA3 region as a network of highly interconnected cells. The neuroscientists at the Institute of Science and Technology Austria (IST Austria) tested this hypothesis using a technique that allows monitoring the connection between electrical signals in up to eight neurons at the same time. Using this octuple recording technique, they made several highly surprising observations. First, they found that connectivity was sparse, with an average connection probability of approximately 1%. This massively challenges the dogma of a network of highly connected cells. Even more surprisingly, they discovered that connectivity in the network is not random, but exhibits connectivity motifs that occur much more frequently than expected for a random network. Thus, the structure of the hippocampal CA3 network may be somewhat reminiscent of a “small world” architecture as found in social networks. Finally, the authors revealed that synaptic connections between two cells are mediated by only one or two synaptic contacts. This is also remarkable because much higher numbers have been found for excitatory synaptic connections in the neocortex.
What could be the functional significance of these highly specific synaptic connectivity rules, in particular in relation to pattern completion? To address this question, Peter Jonas and his team built a model of the CA3 network that incorporates many of these new experimental observations. In contrast to many previous studies, the network was implemented in full size, so that all 330,000 CA3 neurons of the rat hippocampus were simulated. This modeling approach made heavy use of the computer cluster of IST Austria, and was strongly supported by the scientific service unit “scientific computing” of the institute. The authors found that a full-size network model with realistic connectivity of 1% was indeed able to perform the network computation of pattern completion. Furthermore, they discovered that the presence of connectivity motives increased, under certain conditions, the performance of the network. Finally, the design of synaptic connections based on one or two synaptic contacts also seems useful for pattern completion, apparently because it minimizes redundancy in the flow of information in the network. Thus, both macro- (e.g. motifs) and microconnectivity (e.g. properties of connection) facilitate pattern completion in the CA3 cell network. “The results provide a nice demonstration of how the Hopfield quote “build it, and you understand it” can be successfully applied to important questions in neuroscience,” says Peter Jonas, who leads the cellular neuroscience group.
[divider]About this memory research article[/divider]
Source: IST Austria Image Source: NeuroscienceNews.com image is adapted from the IST Austria press release. Original Research: Abstract for “Synaptic mechanisms of pattern completion in the hippocampal CA3 network” by Segundo Jose Guzman, Alois Schlögl, Michael Frotscher, and Peter Jonas in Science. Published online September 9 2016 doi:10.1126/science.aaf1836
[divider]Cite This NeuroscienceNews.com Article[/divider]
[cbtabs][cbtab title=”MLA”]IST Austria. “Synaptic Connectivity Motifs Contribute to Efficient Memory Retrieval in Hippocampus.” NeuroscienceNews. NeuroscienceNews, 12 September 2016. <https://neurosciencenews.com/hippocampus-synaptic-connection-memory-5027/>.[/cbtab][cbtab title=”APA”]IST Austria. (2016, September 12). Synaptic Connectivity Motifs Contribute to Efficient Memory Retrieval in Hippocampus. NeuroscienceNews. Retrieved September 12, 2016 from https://neurosciencenews.com/hippocampus-synaptic-connection-memory-5027/[/cbtab][cbtab title=”Chicago”]IST Austria. “Synaptic Connectivity Motifs Contribute to Efficient Memory Retrieval in Hippocampus.” https://neurosciencenews.com/hippocampus-synaptic-connection-memory-5027/ (accessed September 12, 2016).[/cbtab][/cbtabs]
[divider]Feel free to share this Neuroscience News.[/divider]
Collaborating With Music Therapists to Improve Patient Care
The hippocampal CA3 region plays a key role in learning and memory. Recurrent CA3–CA3 synapses are thought to be the subcellular substrate of pattern completion. However, the synaptic mechanisms of this network computation remain enigmatic. To investigate these mechanisms, we combined functional connectivity analysis with network modeling. Simultaneous recording from up to eight CA3 pyramidal neurons revealed that connectivity was sparse, spatially uniform, and highly enriched in disynaptic motifs (reciprocal, convergence, divergence, and chain motifs). Unitary connections were composed of one or two synaptic contacts, suggesting efficient use of postsynaptic space. Real-size modeling indicated that CA3 networks with sparse connectivity, disynaptic motifs, and single-contact connections robustly generated pattern completion. Thus, macro- and microconnectivity contribute to efficient memory storage and retrieval in hippocampal networks.
“Synaptic mechanisms of pattern completion in the hippocampal CA3 network” by Segundo Jose Guzman, Alois Schlögl, Michael Frotscher, and Peter Jonas in Science. Published online September 9 2016 doi:10.1126/science.aaf1836