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It has long been known that psychiatric disorders, such as schizophrenia, have been associated with a higher risk of type 2 diabetes. In a new study published online in The FASEB Journal, a UMass Medical School research team, led by Rita Bortell, PhD, research professor of molecular medicine and Agata Jurczyk, PhD, instructor in molecular medicine, found that a shared gene (or genes) may underlie the co-occurrence of both diseases. Mutations in Disrupted in Schizophrenia 1 (DISC1) have been strongly associated with major psychiatric disorders, including schizophrenia, but not diabetes. This study presented the first evidence to indicate that the DISC1 gene also plays a novel, unexpected role in pancreatic beta cell survival and function. It is also the first to provide a molecular link for a prevalence of type 2 diabetes in individuals with psychiatric disorders.
To make this discovery, Dr. Bortell and her team genetically manipulated a group of mice to disrupt the DISC1 gene only in the mouse’s pancreatic beta cells, not in the brain. The mice with the disrupted DISC1 gene showed an increase in beta cell death, less insulin secretion and impaired glucose regulation compared to normal mice. When these researchers studied cultured beta cells in which DISC1 expression was suppressed, they found that DISC1 works by inhibiting the activity of a specific protein, GSK3β. Lowered GSK3β activity was already known to be critical for beta cell function and survival. The research team further tested the validity of this association by inhibiting GSK3β function directly. This resulted in improved beta cell survival and restored normal glucose tolerance in mice with disrupted DISC1. These results uncover an unexpected role for DISC1 in normal beta cell physiology and suggest that DISC1 may regulate blood glucose independently of its function in the brain.
“It is known that individuals with psychiatric disorders may be predisposed to developing type 2 diabetes due to several interacting factors including genetics, lifestyle and medications. Based on our mouse studies, our data predict that DISC1 disruption could tip the balance toward disease,” Bortell said, adding that it remains to be demonstrated in humans. “Our hope is that the association we’ve found linking disrupted DISC1 to both diabetes and psychiatric disorders may uncover mechanisms to improve therapies to alleviate suffering caused by both illnesses, which are extraordinarily costly, very common and quite debilitating.”
Bortell said the study points out the potential importance of evaluating new antipsychotic medications for their effects on pancreatic beta cells in addition to the brain. Diligent monitoring for diabetes in those with psychiatric disorders is further warranted by the fact that many antipsychotic medications are also associated with an increased risk of diabetes. “We are also intrigued by the fact that diabetic individuals have higher rates of depression, which suggests that additional molecular links in brain and pancreatic beta cells may yet be discovered,” Bortell said.
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Source: Sarah Willey – UMass Medical School Image Credit: The image is in the public domain Original Research: Abstract for “Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β” by Agata Jurczyk, Anetta Nowosielska, Natalia Przewozniak, Ken-Edwin Aryee, Philip DiIorio, David Blodgett, Chaoxing Yang, Martha Campbell-Thompson, Mark Atkinson, Leonard Shultz, Ann Rittenhouse, David Harlan, Dale Greiner, and Rita Bortell in FASEB Journal. Published online November 6 2015 doi:10.1096/fj.15-279810
Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β
Individuals with schizophrenia and their first-degree relatives have higher rates of type 2 diabetes (T2D) than the general population (18–30 vs. 1.2–6.3%), independent of body mass index and antipsychotic medication, suggesting shared genetic components may contribute to both diseases. The cause of this association remains unknown. Mutations in disrupted in schizophrenia 1 (DISC1) increase the risk of developing psychiatric disorders [logarithm (base 10) of odds = 7.1]. Here, we identified DISC1 as a major player controlling pancreatic β-cell proliferation and insulin secretion via regulation of glycogen synthase kinase-3β (GSK3β). DISC1 expression was enriched in developing mouse and human pancreas and adult β- and ductal cells. Loss of DISC1 function, through siRNA-mediated depletion or expression of a dominant-negative truncation that models the chromosomal translocation of human DISC1 in schizophrenia, resulted in decreased β-cell proliferation (3 vs. 1%; P < 0.01), increased apoptosis (0.1 vs. 0.6%; P < 0.01), and glucose intolerance in transgenic mice. Insulin secretion was reduced (0.5 vs. 0.1 ng/ml; P < 0.05), and critical β-cell transcription factors Pdx1 and Nkx6.1 were significantly decreased. Impaired DISC1 allowed inappropriate activation of GSK3β in β cells, and antagonizing GSK3β (SB216763; IC50 = 34.3 nM) rescued the β-cell defects. These results uncover an unexpected role for DISC1 in normal β-cell physiology and suggest that DISC1 dysregulation contributes to T2D independently of its importance for cognition.—Jurczyk, A., Nowosielska, A., Przewozniak, N., Aryee, K.-E., DiIorio, P., Blodgett, D., Yang, C., Campbell-Thompson, M., Atkinson, M., Shultz, L., Rittenhouse, A. Harlan, D., Greiner, D., Bortell, R. Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β. "Beyond the brain: disrupted in schizophrenia 1 regulates pancreatic β-cell function via glycogen synthase kinase-3β" by Agata Jurczyk, Anetta Nowosielska, Natalia Przewozniak, Ken-Edwin Aryee, Philip DiIorio, David Blodgett, Chaoxing Yang, Martha Campbell-Thompson, Mark Atkinson, Leonard Shultz, Ann Rittenhouse, David Harlan, Dale Greiner, and Rita Bortell in FASEB Journal. Published online November 6 2015 doi:10.1096/fj.15-279810
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