Severe childhood deprivation has longstanding impacts on brain size in adulthood

Summary: Young adults who faced extreme deprivation as children had, on average, an 8.6% smaller brain size than their peers who did not suffer from deprivation. The deprivation related changes in brain volume were associated with lower IQ and increased ADHD symptoms.

Source: King’s College London

Researchers from King’s College London have shown that the brains of young adult Romanian adoptees who were institutionalised as children are around 8.6% smaller than the brains of English adoptees who have not suffered this form of deprivation.

According to the research, the longer the time the Romanian adoptees spent in the institutions, the smaller the total brain volume, with each additional month of deprivation associated with a 0.27% reduction in total brain volume. Deprivation related changes in brain volume were associated with lower IQ and more symptoms of attention deficit hyperactivity disorder (ADHD).

Published in Proceedings of the National Academy of Sciences (PNAS), the study analysed the MRI brain scans of 67 young adults, aged 23-28 years, who were exposed to severely depriving conditions in Romanian institutions under the Communist regime and subsequently adopted into nurturing families in the UK. They were compared to the MRI brain scans of 21 English adoptees aged 23-26 years who had not suffered this institutional deprivation.

MRI scans were conducted at the Centre for Neuroimaging Sciences at King’s College London, as part of the Medical Research Council (MRC) funded English and Romanian Adoptees Brain Imaging Study (ERABIS). This is part of the larger ERA project that has collected information from Romanian and English adoptees over time including measures of mental health and cognitive performance.

This is the first time research has examined the impacts of severe early childhood deprivation on the brain structure of young adults.

Statistical analysis showed that, in this group of young Romanian adults, those changes in brain volume that were related to deprivation were also associated with lower IQ and more ADHD symptoms. This implies that changes in brain structure could play a mediating role between the experience of deprivation and levels of cognitive performance and mental health.

The research investigated other possible factors that could have influenced the results but found the results were unaffected by level of nutrition, physical growth and genetic predisposition for smaller brains.

The principle investigator of the study, Professor Edmund Sonuga-Barke from the Institute of Psychiatry, Psychology & Neuroscience (IoPPN), King’s College London said: ‘The English and Romanian Adoptees (ERA) study addresses one of the most fundamental questions in developmental psychology and psychiatry – how does early experience shape individual development? It’s essential to recognise that these young people have nearly always received great care in loving adoptive families since they left the institutions. However, despite a lot of positive experiences and achievements there remain some deep-seated effects of deprivation on these young adults.’

First author, Dr Nuria Mackes from the IoPPN said: ‘Previous research on the English and Romanian Adoptees (ERA) study has suggested that the emergence and persistence of low IQ and a high level of ADHD symptoms involves structural changes in the brain but, until now, we have not been able to provide direct evidence of this. Showing these very profound effects of early deprivation on brain size and then showing that this difference is associated with low IQ and greater ADHD symptoms provides some of the most compelling evidence of the neuro-biological basis of these problems following deprivation.’

The study also investigated where these changes were occurring in the brain and what localised features contributed to the differences. In comparison to the UK adoptees, the young Romanian adults who had suffered deprivation as children had markedly smaller right inferior frontal regions of the brain both in terms of volume and surface area.

In contrast the right inferior temporal lobe was larger in volume and surface area and thickness for the Romanian young adults and this was associated with lower levels of ADHD symptoms. This implies that this increase in volume and surface area in this region may play a compensatory role in preventing development of ADHD symptoms. In the right medial prefrontal region, the longer the duration of deprivation, the larger the volume and surface area.

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This shows a poor child against a wall
The research investigated other possible factors that could have influenced the results but found the results were unaffected by level of nutrition, physical growth and genetic predisposition for smaller brains. Image is in the public domain.

The neuroimaging lead for the study, Professor Mitul Mehta from the IoPPN said: ‘We found structural differences between the two groups in three regions of the brain. These regions are linked to functions such as organisation, motivation, integration of information and memory. It’s interesting to see the right inferior temporal lobe is in fact larger in the Romanian young adults and that this was related to fewer ADHD symptoms, suggesting that the brain can adapt to reduce the negative effects of deprivation. This may explain why some individuals appear less affected than others by deprivation. We believe this is the first time that research has shown such compelling evidence of compensatory effects around deprivation.’

The Romanian young adults in the study had entered into institutions in the first few weeks of life, where they were often malnourished with minimal social contact and little stimulation. The time spent in institutions before adoption into families in the UK varied between 3 and 41 months.

Reflecting on the implications of the study Professor Sonuga-Barke said: ‘By investigating the long term impact of deprivation our research highlights the need for a life-span perspective on the provision of any help and support, especially during the transition to adulthood. More speculatively the evidence of neural compensation in the inferior temporal lobe provides encouragement to look for ways that might help the brain adjust to deprivation and to improve outcomes. For example, it would be interesting to see if targeting this area directly through cognitive training might reduce ADHD symptoms.’

Funding: The research was published in Proceedings of the National Academy of Sciences and funded by Medical Research Council, Economic and Social Research Council and NIHR Maudsley Biomedical Research Centre.

About this neuroscience research article

Source:
King’s College London
Media Contacts:
Louise Pratt – King’s College London
Image Source:
The image is in the public domain.

Original Research: Open access
“Early childhood deprivation is associated with alterations in adult brain structure despite subsequent environmental enrichment”. Nuria K. Mackes, Dennis Golm, Sagari Sarkar, Robert Kumsta, Michael Rutter, Graeme Fairchild, Mitul A. Mehta, Edmund J. S. Sonuga-Barke, and on behalf of the ERA Young Adult Follow-up team.
PNAS doi:10.1073/pnas.1911264116.

Abstract

Early childhood deprivation is associated with alterations in adult brain structure despite subsequent environmental enrichments

Early childhood deprivation is associated with higher rates of neurodevelopmental and mental disorders in adulthood. The impact of childhood deprivation on the adult brain and the extent to which structural changes underpin these effects are currently unknown. To investigate these questions, we utilized MRI data collected from young adults who were exposed to severe deprivation in early childhood in the Romanian orphanages of the Ceaușescu era and then, subsequently adopted by UK families; 67 Romanian adoptees (with between 3 and 41 mo of deprivation) were compared with 21 nondeprived UK adoptees. Romanian adoptees had substantially smaller total brain volumes (TBVs) than nondeprived adoptees (8.6% reduction), and TBV was strongly negatively associated with deprivation duration. This effect persisted after covarying for potential environmental and genetic confounds. In whole-brain analyses, deprived adoptees showed lower right inferior frontal surface area and volume but greater right inferior temporal lobe thickness, surface area, and volume than the nondeprived adoptees. Right medial prefrontal volume and surface area were positively associated with deprivation duration. No deprivation-related effects were observed in limbic regions. Global reductions in TBV statistically mediated the observed relationship between institutionalization and both lower intelligence quotient (IQ) and higher levels of attention deficit/hyperactivity disorder symptoms. The deprivation-related increase in right inferior temporal volume seemed to be compensatory, as it was associated with lower levels of attention deficit/hyperactivity disorder symptoms. We provide compelling evidence that time-limited severe deprivation in the first years of life is related to alterations in adult brain structure, despite extended enrichment in adoptive homes in the intervening years.

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