The brain’s auto-complete function

Summary: Neurons in the entorhinal cortex fire in parallel to hippocampal neurons during associative memory tasks.

Source: University of Bonn

When looking at a picture of a sunny day at the beach, we can almost smell the scent of sunscreen. Our brain often completes memories and automatically brings back to mind the different elements of the original experience. A new collaborative study between the Universities of Birmingham and Bonn now reveals the underlying mechanisms of this auto-complete function. It is now published in the journal Nature Communications.

The researchers presented participants with a number of different scene images. Importantly, they paired each scene image with one of two different objects, such as a raspberry or a scorpion. Participants were given 3 seconds to memorize a given scene-object combination. After a short break they were presented with the scene images again but now had to reconstruct the associated object image from memory.

“At the same time, we examined participants’ brain activation”, explains Prof. Florian Mormann, who heads the Cognitive and Clinical Neurophysiology group at the University of Bonn Medical Centre.

“We focused on two brain regions – the hippocampus and the neighboring entorhinal cortex.” The hippocampus is known to play a role in associative memory, but how exactly it does so has remained poorly understood.

The researchers made an exciting discovery: During memory recall, neurons in the hippocampus began to fire strongly. This was also the case during a control condition in which participants only had to remember scene images without the objects. Importantly, however, hippocampal activity lasted much longer when participants also had to remember the associated object (the raspberry or scorpion image). Additionally, neurons in the entorhinal cortex began to fire in parallel to the hippocampus.

“The pattern of activation in the entorhinal cortex during successful recall strongly resembled the pattern of activation during the initial learning of the objects”, explains Dr. Bernhard Staresina from the University of Birmingham. Indeed, the similarity between recall and learning was so strong that a computer algorithm was able to tell whether the participant remembered the raspberry or the scorpion. “We call this process reinstatement”, Staresina says: “The act of remembering put neurons in a state that strongly resembles their activation during initial learning.”

The researchers think that such reinstatement is driven by neurons in the hippocampus. Like a librarian, hippocampal neurons might provide pointers telling the rest of the brain where particular memories (such as the raspberry and the scorpion) are stored.

Looking into the brain of Epilepsy patients

The brain recordings were conducted at the University Clinic of Epileptology in Bonn – one of Europe’s biggest epilepsy centers. The clinic specializes in patients who suffer from severe forms of medial temporal lobe epilepsy. The goal is to surgically remove those parts of the brain that cause epileptic seizures. In order to localize the origin of the seizures, some patients are implanted with electrodes. These electrodes are able to record brain activation. Researchers can use this rare opportunity to closely monitor the brain while it remembers.

This shows a picture of a raspberry and scorpion
Participants first saw images of scenes together with one of two objects. Later they only saw the scene images and were asked to remember which object was associated with the particular scene. The image is credited to Cognitive and Clinical Neurophysiology Group/Uni Bonn.

This is also what the current study did: The 16 participants were all epilepsy patients who had small electrodes implanted in their medial temporal lobe. “With these electrodes, we were able to record the neurons’ response to visual stimuli”, Prof. Mormann explains. These methods allow fascinating insights into the mechanisms of our memory system. They might also be used to better understand the causes of memory deficits.

About this neuroscience research article

Source:
University of Bonn
Media Contacts:
Bernhard Staresina – University of Bonn
Image Source:
The image is credited to Cognitive and Clinical Neurophysiology Group/Uni Bonn.

Original Research: Open access
Bernhard P. Staresina, Thomas P. Reber, Johannes Niediek, Jan Boström, Christian E. Elger und Florian Mormann: “Recollection in the human hippocampal-entorhinal cell circuitry”; Nature Communications doi:10.1038/s41467-019-09558-3

Abstract

Recollection in the human hippocampal-entorhinal cell circuitry

Imagine how flicking through your photo album and seeing a picture of a beach sunset brings back fond memories of a tasty cocktail you had that night. Computational models suggest that upon receiving a partial memory cue (‘beach’), neurons in the hippocampus coordinate reinstatement of associated memories (‘cocktail’) in cortical target sites. Here, using human single neuron recordings, we show that hippocampal firing rates are elevated from ~ 500–1500 ms after cue onset during successful associative retrieval. Concurrently, the retrieved target object can be decoded from population spike patterns in adjacent entorhinal cortex (EC), with hippocampal firing preceding EC spikes and predicting the fidelity of EC object reinstatement. Prior to orchestrating reinstatement, a separate population of hippocampal neurons distinguishes different scene cues (buildings vs. landscapes). These results elucidate the hippocampal-entorhinal circuit dynamics for memory recall and reconcile disparate views on the role of the hippocampus in scene processing vs. associative memory.

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