Researchers launch the first-in-human phase 1 clinical trial to assess the safety and efficacy of a gene therapy which will deliver BDNF to the brains of those with Alzheimer's and mild cognitive impairment. Read More
Two new studies advance understanding of how the brain encodes episodic memories. The findings have the potential to develop new avenues of treatment for memory loss associated with Alzheimer's disease and TBI. Read More
Anxiety may accelerate the progression of mild cognitive impairment to Alzheimer's disease. Brain scans revealed patients who progressed from MCI to Alzheimer's disease had decreased volume in the hippocampus and entorhinal cortex. Read More
Researchers have identified a new mechanism of learning that stabilizes memory and reduces interference between different memories. Read More
Grid cell dysfunction in the entorhinal cortex may explain why people with a genetic risk factor for Alzheimer's disease have problems with navigation. Read More
Your personality traits might indicate whether you are at an increased risk of developing Alzheimer's disease as you age. Those who are less agreeable and more confrontational appear to have better neuroprotection against the disease. Lower agreeableness was associated with lower brain volume loss in the hippocampus, entorhinal cortex, and other areas linked to memory. Higher openness was also associated with lower brain volume loss in the hippocampus. The data suggests a combination of lower agreeableness and higher openness could be independent predictors of the preservation of brain volume in areas vulnerable to neurodegeneration. Read More
Amyloid accumulation occurs faster in those who have objectively-defined cognitive difficulties than older people who are considered to be cognitively normal. Mild cognitive impairment is also associated with faster hippocampal and entorhinal cortex atrophy. Read More
Subtle changes in thinking and memory may appear before, or in conjunction with, the development of amyloid plaques. Read More
Cortical and subcortical memory regions exhibit distinct genetic signatures that reflect potential differences in health and disease. Read More
Neural activity in the entorhinal cortex is correlated with place-based memories. The findings shed new light on how the brain processes spatial memory. Read More
Using brain scans and virtual reality technology, researchers discover how a temporal map of memories is generated in the entorhinal cortex. Read More
The postrhinal cortex of rats contains three types of spatial cells which act together to provide a sense of location and directional orientation. Read More
