Researchers identified specific receptors for acetylcholine that reroute information flow through memory circuits in the hippocampus. The findings could have implications for the development of drugs to help enhance or protect memory from diseases associated with cognitive decline.
The cognitive map allows people to compute on the fly with limited information to solve abstract problems.
A new system within the brain uses for information processing and memory storage has been discovered. The findings provide novel insight into how the brain functions.
Researchers launch the first-in-human phase 1 clinical trial to assess the safety and efficacy of a gene therapy which will deliver BDNF to the brains of those with Alzheimer's and mild cognitive impairment.
Two new studies advance understanding of how the brain encodes episodic memories. The findings have the potential to develop new avenues of treatment for memory loss associated with Alzheimer's disease and TBI.
Anxiety may accelerate the progression of mild cognitive impairment to Alzheimer's disease. Brain scans revealed patients who progressed from MCI to Alzheimer's disease had decreased volume in the hippocampus and entorhinal cortex.
Grid cell dysfunction in the entorhinal cortex may explain why people with a genetic risk factor for Alzheimer's disease have problems with navigation.
Your personality traits might indicate whether you are at an increased risk of developing Alzheimer's disease as you age. Those who are less agreeable and more confrontational appear to have better neuroprotection against the disease. Lower agreeableness was associated with lower brain volume loss in the hippocampus, entorhinal cortex, and other areas linked to memory. Higher openness was also associated with lower brain volume loss in the hippocampus. The data suggests a combination of lower agreeableness and higher openness could be independent predictors of the preservation of brain volume in areas vulnerable to neurodegeneration.
Amyloid accumulation occurs faster in those who have objectively-defined cognitive difficulties than older people who are considered to be cognitively normal. Mild cognitive impairment is also associated with faster hippocampal and entorhinal cortex atrophy.
Subtle changes in thinking and memory may appear before, or in conjunction with, the development of amyloid plaques.