entorhinal cortex

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entorhinal cortex

·November 6, 2022·6 min read

A Novel Instructive Role for the Entorhinal Cortex

Researchers have identified a new type of synaptic plasticity they call behavioral timescale synaptic plasticity (BTSP). The study reveals how the entorhinal cortex sends instructive signals to the hippocampus and directs it to specifically reorganize the specific location and activity of a neural subset to achieve altered behavior in response to changes in environment and spatial cues.

Featured Genetics Neurology Visual Neuroscience

·July 26, 2022·4 min read

Changes in the Retina Can Be Linked to Parts of the Brain of Healthy Subjects at Risk of Alzheimer’s

In cognitively healthy people with a genetic risk for Alzheimer's, retinal changes have been associated with alterations in the entorhinal cortex, hippocampus, and lingual gyrus. Researchers say retinal changes can be used to track changes in brain structures associated with Alzheimer's in those with genetic risk factors.

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Featured Genetics Neurology Neuroscience

·April 13, 2022·4 min read

Why Certain Brain Neurons Are Vulnerable to Degeneration

Wolframin-expressing excitatory neurons (WFS1) are more vulnerable in the entorhinal cortex.WFS1 may reduce tau-pathology and neurodegeneration via the regulation of stress response to the abnormal buildup of tau aggregates and the downstream protein degradation pathway.

Featured Neuroscience

·December 6, 2021·4 min read

Study Find First in Human Evidence of How Memories Form

Researchers have identified the characteristics of over 100 memory-sensitive neurons that play a key role in how memories are recalled in the brain.

Electrophysiology Featured Neuroscience

·September 22, 2021·4 min read

Sniffing Out How Associative Memories Are Formed

Dopamine-controlled fan cells in the lateral entorhinal cortex are required for the formation of associative memories.

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Featured Neuroscience Open Neuroscience Articles

·September 16, 2021·3 min read

Drug Targets for Memory Enhancement

Researchers identified specific receptors for acetylcholine that reroute information flow through memory circuits in the hippocampus. The findings could have implications for the development of drugs to help enhance or protect memory from diseases associated with cognitive decline.

Featured Neuroscience

·September 3, 2021·4 min read

New Model for Solving Novel Problems Uses Mental Map

The cognitive map allows people to compute on the fly with limited information to solve abstract problems.

Featured Neuroscience

·August 7, 2021·3 min read

Switching System Used in Information Processing and Memory Revealed

A new system within the brain uses for information processing and memory storage has been discovered. The findings provide novel insight into how the brain functions.

Featured Genetics Neurology Psychology

·June 17, 2021·3 min read

Depression and Tau Deposits Seen in Subset of Middle-Aged Persons

Depressed middle-aged carriers of the APOEe4 Alzheimer's genetic variant are at risk of developing tau accumulations in brain areas associated with emotion and memory.

Featured Genetics Neurology

·February 19, 2021·4 min read

First-in-Human Clinical Trial to Assess Gene Therapy for Alzheimer’s Disease

Researchers launch the first-in-human phase 1 clinical trial to assess the safety and efficacy of a gene therapy which will deliver BDNF to the brains of those with Alzheimer's and mild cognitive impairment.

Featured Neuroscience

·December 8, 2020·7 min read

How the Brain Remembers Right Place and Right Time

Two new studies advance understanding of how the brain encodes episodic memories. The findings have the potential to develop new avenues of treatment for memory loss associated with Alzheimer's disease and TBI.

Featured Neurology Neuroscience Psychology

·November 24, 2020·3 min read

Anxiety Associated With Faster Alzheimer’s Disease Onset

Anxiety may accelerate the progression of mild cognitive impairment to Alzheimer's disease. Brain scans revealed patients who progressed from MCI to Alzheimer's disease had decreased volume in the hippocampus and entorhinal cortex.

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