Brain Abnormalities in Children with Developmental Language Disorder

Summary: Researchers have discovered that the anterior neostriatum, a part of the brain linked with movement, shows abnormalities in children with developmental language impairments. This study utilized a novel computational approach to analyze data from 22 studies, revealing that these abnormalities are uniquely prevalent in the anterior neostriatum.

The findings could revolutionize diagnosis and treatment, offering new pathways for early detection and potentially leveraging drugs that address basal ganglia dysfunction. This study emphasizes the importance of further research to explore how these findings can directly benefit those with developmental language disorders.

Key Facts:

  1. Developmental Language Disorder Prevalence: This condition is as common as ADHD and dyslexia, and more prevalent than autism, affecting a significant number of children.
  2. Unique Abnormalities Identified: The anterior neostriatum within the basal ganglia shows abnormalities in 100% of studies analyzed, highlighting a specific target for understanding and treating language impairments.
  3. Potential for Early Diagnosis and Treatment: The findings suggest that basal ganglia abnormalities could serve as early biomarkers for developmental language disorders, opening the door for early intervention and tailored therapies.

Source: Georgetown University Medical Center

A rigorous analysis of numerous studies concludes that a part of the brain traditionally associated with movement is abnormal in children with developmental language impairments, according to Georgetown University Medical Center neuroscientists.

The discovery has the potential to improve both the diagnosis and treatment of the language difficulties.

The researchers investigated brain abnormalities in developmental language disorder. This condition, which impacts the development of various aspects of language, is about as common as attention-deficit/hyperactivity disorder (ADHD) and dyslexia, and more prevalent than autism.

This shows a child holding a brain.
They determined that the anterior neostriatum was abnormal in 100% of the studies that examined the structure, with fewer abnormalities in all other parts of the brain. Credit: Neuroscience News

The scientists found that abnormalities occurred specifically in the anterior neostriatum within the basal ganglia, a structure found deep in the brain. They describe their findings in Nature Human Behaviour on March 15.

To better understand why the language impairments occur, the researchers analyzed the results of 22 articles examining brain structures in people with the disorder, and then employed a new computational method to identify common patterns of abnormalities across the studies.

They determined that the anterior neostriatum was abnormal in 100% of the studies that examined the structure, with fewer abnormalities in all other parts of the brain.

“We hope that by identifying the neural bases of developmental language difficulties we may help increase awareness of a major, but also rather unrecognized, disorder,” says the study’s lead author Michael T. Ullman, PhD, professor of neuroscience and director of the Brain and Language Laboratory at Georgetown University Medical Center.

“We caution, however, that further research is necessary to understand exactly how the anterior neostriatum might lead to the language difficulties.”

Ullman says the findings underscore the potential utility of drugs that are known to improve movement impairments due to basal ganglia dysfunction, such as those that act on dopamine receptors. Interventions that encourage compensation by intact brain structures may also be useful.

Additionally, basal ganglia abnormalities could potentially serve as early biomarkers of an increased likelihood of developmental language problems. Such early warning signs could trigger further diagnostic procedures, potentially leading to early therapy.

“Continuing research efforts to further understand the neurobiology of developmental language disorder, especially the role of the basal ganglia, could help the many children who are affected by these problems,” concludes Ullman.

In addition to Ullman, other authors at Georgetown include Mariel Pullman, Jarrett Lovelett, Xiong Jiang, and Peter Turkeltaub. Gillian Clark was at Deakin University, Melbourne, Australia. Elizabeth Pierpont is at the University of Minnesota Medical Center, Minneapolis.

Funding: This work was supported by NIH grants R01 HD049347 and R21 HD 087088; NSF grants BCS 1439290 and BCS 1940980; and funding from the Mabel H. Flory Trust.

The authors declare no personal financial interests related to the study.

About this language development research news

Author: Karen Teber
Source: Georgetown University Medical Center
Contact: Karen Teber – Georgetown University Medical Center
Image: The image is credited to Neuroscience News

Original Research: The findings will appear in Nature Human Behavior

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