Brown Fat Keeps Blood Sugar in Check

Australian scientists have shown that brown fat – a special type of fat that burns energy to produce heat – may also help to keep blood sugar steady in adults.

Researchers at Sydney’s Garvan Institute of Medical Research measured brown fat activity and blood glucose continuously in real time in study participants, and found that individuals with more brown fat had smaller fluctuations in blood sugar. Their findings open new avenues for diabetes therapies that target brown fat.

The incidence of type 2 diabetes, which is characterised by high blood sugar, is reaching epidemic proportions worldwide. There is a need for new insights into how blood sugar levels can be controlled, beyond mechanisms actioned by currently available therapies.

Now, researchers at Garvan have shown that brown fat may help to minimise fluctuations in blood sugar (blood glucose) concentration in adults. Their work is published today in the prestigious journal Cell Metabolism.

Unlike white fat, which primarily stores energy, brown fat burns energy – often in remarkably large amounts. Sitting just above the collarbone and in the neck, brown fat acts like a heat generator, helping to keep us warm by burning sugar and fat.

Dr Paul Lee and Associate Professor Jerry Greenfield, of Garvan’s Diabetes and Metabolism Division, have long been interested in whether brown fat might have a role beyond keeping us cosy.

Dr Lee says, “Brown fat takes up so much glucose that we wondered whether brown fat could affect the concentration of glucose in the blood – and whether, therefore, brown fat-targeted therapies might help control diabetes.

“Previously, we showed that individuals with large brown fat stores tend to be lean and have lower blood glucose – and now, we have uncovered a potential link between brown fat activity and blood glucose variations.”

The research team studied a group of 15 healthy adults over 12 hours. They found that blood glucose levels and heat production by brown fat were closely related, tracking together over time.

Importantly, participants who had larger deposits of brown fat had less fluctuation in blood glucose – and blood glucose fell after each peak of brown fat activity surge.

In contrast, brown fat activity rose only in response to an increase in blood glucose among those with less brown fat, and interestingly, their glucose fluctuations were greater. Notably, individuals with no detectable brown fat had the widest fluctuations in blood glucose.

Dr Lee says, “It looks like the more brown fat one has, the more influence it has on blood glucose.

“Our findings indicate that brown fat might act as a ‘glucose buffer’, lessening the variation in blood glucose and potentially diminishing metabolic stresses that could increase the risk of diabetes.”

The study used a simple and non-invasive technique to measure brown fat activity: a small thermometer placed over the collarbone of participants.

Dr Lee says, “Brown fat sits just under the skin, and it heats up when it’s active. So, measuring skin temperature at the collarbone can allow us to estimate brown fat activity.

“This is the first time we have been able to simultaneously estimate brown fat activity and glucose changes continuously in real time. While it’s an indirect measure, it offers an opportunity to examine how brown fat relates to glucose during daily living.”

Image shows brown far in the collarbone.
Brown fat is visible on a PET scan as red coloration around the collarbone. The scan detects a glucose tracer, which is visible in the most metabolically active organs. Credit: Garvan Institute of Medical Research.

The researchers also made an intriguing observation: brown fat activity rose at dawn, around the time volunteers were waking from sleep. Dr Lee says, “We speculate that this early morning temperature boost may have an evolutionary origin, generating heat and preparing our ancestors for hunting and gathering in the cold as the day begins.”

Dr Lee says that brown fat-based therapies are potentially promising in the fight against diabetes in the future, but also urges caution.

“The study brings brown fat into the frame for developing diabetes therapies. If we can pinpoint what switches brown fat’s activity on and off during the day, we may identify new targets in drug design.

“Brown fat is interesting and promising – but it is not the solution to finding a cure for diabetes, at least not now. A balanced diet and regular exercise are the cornerstones of healthy metabolism and should not be forgotten.”

About this neuroscience research

Funding: Funding was provided by Australian National Health and Medical Research Council, Diabetes Australia Research Trust, Royal Australasian College of Physicians.

Source: Meredith Ross – Garvan Institute of Medical Research
Image Credit: The image is credited to Garvan Institute of Medical Research.
Original Research: Abstract for “Brown Adipose Tissue Exhibits a Glucose-Responsive Thermogenic Biorhythm in Humans” by Paul Lee, Ron Bova, Lynne Schofield, Wendy Bryant, William Dieckmann, Anthony Slattery, Matt A. Govendir, Louise Emmett, and Jerry R. Greenfield in Cell Metabolism. Published online March 10 2016 doi:10.1016/j.cmet.2016.02.007


Abstract

Brown Adipose Tissue Exhibits a Glucose-Responsive Thermogenic Biorhythm in Humans

High abundance of brown adipose tissue (BAT) is linked to lower glycaemia in humans, leading to the belief that BAT may protect against diabetes. The relationship between BAT glucose utilization and systemic glucose homeostasis has not been defined. In this paper we have characterized glycaemic excursions and BAT thermogenic responses in human brown adipocytes, BAT explants, and healthy adults through supraclavicular temperature profiling, revealing their circadian coupling in vivo and in vitro, orchestrated by UCP1, GLUT4, and Rev-erbα biorhythms. Extent of glycated haemoglobin also correlated positively with environmental temperature among community-dwelling patients. These data uncover potential crosstalk between BAT and glucose regulatory pathways, evident on cellular, tissue, individual, and population levels, and provide impetus to search for BAT harnessing strategies for therapeutic purposes.

“Brown Adipose Tissue Exhibits a Glucose-Responsive Thermogenic Biorhythm in Humans” by Paul Lee, Ron Bova, Lynne Schofield, Wendy Bryant, William Dieckmann, Anthony Slattery, Matt A. Govendir, Louise Emmett, and Jerry R. Greenfield in Cell Metabolism. Published online March 10 2016 doi:10.1016/j.cmet.2016.02.007

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