Summary: Supplementing a diet with Ascidiacea, or sea squirts, reversed some of the main signs of aging in mouse models.
Source: Xi’an jiaotong-Liverpool University
If you have ever looked in the mirror and seen graying hair and wrinkles or forgotten the name of a close friend, you’d be forgiven for wishing for a pill that could slow or even reverse the effects of aging.
A new study suggests that this may not be such a fantasy. Researchers from Xi’an Jiaotong-Liverpool University, Stanford University, Shanghai Jiao tong University, and the University of Chinese Academy of Sciences have reported that supplementing a diet with the sea organisms Ascidiacea, also known as sea squirts, reverses some of the main signs of aging in an animal model.
Sea squirts can be eaten raw and are found in dishes from Korea (where it is known as meongge, or 멍게) and Japan (hoya, or ホヤ). These sea organisms contain substances called plasmalogens, which are vital to our body processes.
Plasmalogens are found all over our bodies naturally, particularly in the heart, brain and immune cells, but as we get older, the amount in our body decreases. This loss is also a characteristic of several neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease.
To investigate whether boosting the levels of plasmalogens can stave off the effects of aging, the researchers studied the effects of adding plasmalogens to the diet of aged mice.
They found that the supplements had profound effects on the learning abilities and physical symptoms of these mice.
Professor Lei Fu, the corresponding author of the study, says: “Our research suggests that plasmalogens may not just stop cognitive decline, but may reverse cognitive impairments in the aging brain. Additionally, aged mice fed with the plasmalogens grow new black hair that is thicker and glossier than aged mice not fed the supplement.”
This study is the first to show, in detail, how plasmalogens affect the aging brain.
Making new connections
The effects of the plasmalogen supplement on learning and memory were tested by training mice to use a Morris water maze—a pool of water that contains a platform that serves as a resting area. Generally, mice do not like to swim, so over five days of training, they remember where the platform is and swim directly to it as soon as they are in the pool. However, older mice take longer to find the platform after the same amount of training.
Astonishingly, when fed with plasmalogens, aged mice perform more like young mice, finding the platform much quicker than the control group of aged mice that have not been given the supplement.
To find the reason for the improvement shown by plasmalogen-fed mice, the researchers took a closer look at changes happening within the brain. They found that mice that were fed the plasmalogen supplement had a higher number and quality of synapses—the connections between neurons—than the aged mice not given the supplements.
Synapses are a fundamental part of our neural networks and, therefore, crucial for learning and memory. Our synapses tend to be very plastic as children, but they decrease in number and deteriorate with age and in neurogenerative diseases, resulting in cognitive impairments.
Accordingly, in this study, the aged mice fed with plasmalogen supplements showed greater potential for learning new skills and creating new neural networks than the aged mice whose diet was not supplemented. This suggests that dietary plasmalogens can halt the age-related deterioration of synapses.
A further characteristic of getting older, and thought to be a significant factor in neurodegeneration, is inflammation in the brain. Too much inflammation can have a negative effect on cognitive ability, as the brain’s immune system becomes overactive and turns on itself, attacking neurons and preventing synapses from functioning correctly.
In this study, the inflammation in aged mice was greatly decreased in those given plasmalogen supplements compared to those on a normal diet, providing some insight as to why they performed better in learning and memory tasks.
Possible pathways of action
Although it is still unclear how dietary plasmalogen supplements seem to cause such significant changes in learning and memory, Professor Fu speculates on possible pathways of action.
“We found that plasmalogens significantly increase the number of molecules that aid the growth and development of neurons and synapses in the brain. This suggests that plasmalogens can promote neurodegeneration.
“There is also an increasing body of evidence that plasmalogens directly affect the structural properties of synapses. Plasmalogens may increase the fluidity and flexibility of synaptic membranes, affecting the transmission of impulses between neurons.”
Additionally, Professor Fu explains that plasmalogens may also have indirect effects on our brains.
“Some studies have shown that dietary plasmalogens affect the microorganisms in the gut. It has been widely reported that the connection between the organisms in our gut and our brain influences neurodegeneration. It may be the plasmalogen’s effect on this connection that causes the improvements in learning and memory seen in this study.”
Professor Fu is so convinced by the results of this study that he takes a plasmalogen supplement each day.
“For the first time, we show that plasmalogen supplements might be a potential intervention strategy for halting neurodegeneration and promoting neuroregeneration.
Plasmalogens Eliminate Aging-Associated Synaptic Defects and Microglia-Mediated Neuroinflammation in Mice
Neurodegeneration is a pathological condition in which nervous system or neuron losses its structure, function, or both leading to progressive neural degeneration. Growing evidence strongly suggests that reduction of plasmalogens (Pls), one of the key brain lipids, might be associated with multiple neurodegenerative diseases, including Alzheimer’s disease (AD).
Plasmalogens are abundant members of ether-phospholipids. Approximately 1 in 5 phospholipids are plasmalogens in human tissue where they are particularly enriched in brain, heart and immune cells. In this study, we employed a scheme of 2-months Pls intragastric administration to aged female C57BL/6J mice, starting at the age of 16 months old.
Noticeably, the aged Pls-fed mice exhibited a better cognitive performance, thicker and glossier body hair in appearance than that of aged control mice.
The transmission electron microscopic (TEM) data showed that 2-months Pls supplementations surprisingly alleviate age-associated hippocampal synaptic loss and also promote synaptogenesis and synaptic vesicles formation in aged murine brain.
Further RNA-sequencing, immunoblotting and immunofluorescence analyses confirmed that plasmalogens remarkably enhanced both the synaptic plasticity and neurogenesis in aged murine hippocampus. In addition, we have demonstrated that Pls treatment inhibited the age-related microglia activation and attenuated the neuroinflammation in the murine brain.
These findings suggest for the first time that Pls administration might be a potential intervention strategy for halting neurodegeneration and promoting neuroregeneration.