We Cannot Cheat Aging and Death

Summary: Findings shed new light on the invariant rate of aging hypothesis, providing fresh evidence that death is inevitable.

Source: University of Southern Denmark

A study led by Fernando Colchero, University of Southern Denmark and Susan Alberts, Duke University, North Carolina, that included researchers from 42 institutions across 14 countries, provides new insights into the aging theory “the invariant rate of aging hypothesis”, which states that every species has a relatively fixed rate of aging.

“Human death is inevitable. No matter how many vitamins we take, how healthy our environment is or how much we exercise, we will eventually age and die,” said Fernando Colchero.

He is an expert in applying statistics and mathematics to population biology and an associate professor at Department of Mathematics and Computer Science, University of Southern Denmark.

“We were able to shed light on the invariant rate of aging hypothesis by combining an unpresented wealth of data and comparing births and deaths patterns on nine human populations with information from 30 non-human primate populations, including gorillas, chimpanzees and baboons living in the wild and in zoos,” said Fernando Colchero.

In order to explore this hypothesis, the researchers analyzed the relationship between life expectancy, this is the average age at which individuals die in a population, and lifespan equality, which measures how concentrated deaths are around older ages.

Their results show that, as life expectancy increases, so does lifespan equality. So, lifespan equality is very high when most of the individuals in a population tend to die at around the same age such as observed in modern Japan or Sweden – which is around their 70s or 80s. However, in the 1800s lifespan equality was very low in those same countries, since deaths were less concentrated at old ages, resulting also in lower life expectancy.

“Life expectancy has increased dramatically and still does in many parts of the world. But this is not because we have slowed our rate of aging; the reason is that more and more infants, children and young people survive and this brings up the average life expectancy,” said Fernando Colchero.

Previous research from some of the authors of the study has unraveled the striking regularity between life expectancy and lifespan equality among human populations, from pre-industrial European countries, hunter gatherers, to modern industrialize countries.

This shows an old lady's hands
Their results show that, as life expectancy increases, so does lifespan equality. Image is in the public domain

However, by exploring these patterns among our closest relatives, this study shows that this pattern might be universal among primates, while it provides unique insights into the mechanisms that produce it.

“We observe that not only humans, but also other primate species exposed to different environments, succeed in living longer by reducing infant and juvenile mortality. However, this relationship only holds if we reduce early mortality, and not by reducing the rate of ageing” said Fernando Colchero.

Using statistics and mathematics the authors show that even small changes in the rate of ageing would make a population of, say, baboons, to demographically behave as a population of chimpanzees or even humans.

‘Not all is lost’, says Fernando Colchero, ‘medical science has advanced at an unprecedented pace, so maybe science might succeed in achieving what evolution could not: to reduce the rate of ageing’.

Funding: This work was supported by NIA P01AG031719, with additional support provided by the Max Planck Institute of Demographic Research and the Duke University Population Research Institute.

About this aging research news

Source: University of Southern Denmark
Contact: Press Office – University of Southern Denmark
Image: The image is in the public domain

Original Research: Open access.
The Long Lives of Primates and the ‘Invariant Rate of Ageing’ Hypothesis” by F. Colchero, J.M. Aburto, E.A. Archie, C. Boesch, T. Breuer, F.A. Campos, A. Collins, D.A. Conde, M. Cords, C. Crockford, M.E. Thompson, L.M. Fedigan, C. Fichtel, M. Groenenberg, C. Hobaiter, P.M. Kappeler, R.R. Lawler, R.J. Lewis, Z.P. Machanda, M.L. Manguette, M.N. Muller, C. Packer, R.J. Parnell, S. Perry, A.E. Pusey, M.M. Robbins, R.M. Seyfarth, J.B. Silk, J. Staerk, T.S. Stoinski, E.J. Stokes, K.B. Strier, S.C. Strum, J. Tung, F. Villavicencio, R.M. Wittig, R.W. Wrangham, K. Zuberbühler, J.W. Vaupel, S.C. Alberts. Nature Communications


Abstract

The Long Lives of Primates and the ‘Invariant Rate of Ageing’ Hypothesis

Is it possible to slow the rate of ageing, or do biological constraints limit its plasticity? We test the ‘invariant rate of ageing’ hypothesis, which posits that the rate of ageing is relatively fixed within species, with a collection of 39 human and nonhuman primate datasets across seven genera.

We first recapitulate, in nonhuman primates, the highly regular relationship between life expectancy and lifespan equality seen in humans. We next demonstrate that variation in the rate of ageing within genera is orders of magnitude smaller than variation in pre-adult and age-independent mortality.

Finally, we demonstrate that changes in the rate of ageing, but not other mortality parameters, produce striking, species-atypical changes in mortality patterns.

Our results support the invariant rate of ageing hypothesis, implying biological constraints on how much the human rate of ageing can be slowed.

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  1. Bns días. Me a gustado mucho lo que uds publican. Muy interesante.

  2. Of course death is inevitable. It is a statistical certainty that something will cause your death, be it calamity or a medical crisis. All we can do is improve the probability of being on the good end of the bell curve by living a low risk healthy life. The rest is up to God.

  3. Death is a normal expectancy
    I am not a Doctor but bad habits such as smoking decrease health drastically
    5 Years without smoking and I can exercise and breath better I do not eat fast food so I cannot comment on food diseases
    Breathing easier is a blessing..

  4. My dad died at 90…..probably could have hit 100 easily. His grandmother lived to 126 (church records) one of his “younger sisters lived til 91”. My mom stressed & died at 83.
    I wish I were as lucky.

  5. Previous research from some of the authors of the study has unraveled the striking regularity between life expectancy and lifespan equality among human populations, from pre-industrial European countries, hunter gatherers, to modern industrialize countries.

    Should read ‘industrialized’.

  6. According to our medical system, the only reason a person dies is because they didn’t take enough big pharma drugs. At least, that is how it appears to be. The presumed expansion of life makes sense when you consider that the averages are being boosted by fewer deaths at early ages. My dad just turned 94 but doesn’t exercise, or eat many fruits and veggies, eats fast food, and generally can get around and still drives. I can’t figure it out.

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