Summary: Researchers unlocked the mechanism behind the tight feeling of our skin post-cleanse and its relief post-moisturization.
The study shows how external products induce mechanical changes on the skin’s surface, creating sensations we can feel. By understanding this skin ‘language’, scientists can now predict our skin’s response to various products.
The findings open doors to innovations in skincare formulations and potential non-verbal communication devices.
Using donor skin samples, the study found that cleansers strip lipids, contracting the skin’s outer layer, while moisturizers induce swelling by increasing water content.
The mechanical forces from skin’s contraction or swelling affect mechanoreceptors below the skin, which send signals to our brain, interpreted as skin tightness.
The skin tightness predictions from the research correlated nearly perfectly with real human trials, suggesting the potential for improved product formulations.
When we wash our face with a cleanser, our skin can start to feel tight. With the application of a favorite moisturizer, that feeling often goes away. This perception of our skin might seem subjective, but researchers at Stanford recently revealed the mechanism behind these feelings.
Their work, published this week in PNAS Nexus, demonstrates how mechanical changes at the outer surface of our skin translate into sensations and provides a quantitative approach for determining how people will perceive their skin after using a moisturizer or cleanser.
“This work provides a new understanding of how products affect the physical properties of our skin, which includes not just skin health, but also skin sensorial perception. That’s a significant advance,” said Reinhold Dauskardt, the Ruth G. and William K. Bowes Professor in Stanford’s Department of Materials Science and Engineering. “It provides a whole new understanding of how to design those formulations.”
Our skin is the largest organ in our body and it’s constantly exposed to the environment around us. The outermost layer of our skin – the stratum corneum – acts as a barrier to keep out unwanted chemicals and bacteria and to keep in moisture. When we use a harsh cleanser, it strips away some of the lipids that hold in moisture, causing the stratum corneum to contract. A good moisturizer increases the water content of the stratum corneum, causing it to swell.
Dauskardt and his colleagues predicted that the mechanical forces created by this shrinking or swelling propagate through the skin to reach mechanoreceptors – sensory receptors that turn mechanical force into neurological signals – below the epidermis, which then fire off signals to the brain that we interpret as a feeling of skin tightness.
To test their theory, the researchers studied the effects of nine different moisturizing formulas and six different cleansers on donor skin samples from three locations on the human body – cheek, forehead, and abdomen. They measured changes in the stratum corneum in the lab and then fed that information into a sophisticated model of human skin to predict the signals that the mechanoreceptors would send.
“We were able to rank the different formulations in terms of what subjects should say about the sensorial perception of their skin,” Dauskardt said.
The predictions from their analysis lined up almost perfectly with what people reported in human trials for each formula. Collaborators at L’Oréal Research and Innovation recruited 2,000 women in France to assess the nine moisturizers and 700 women in China to assess the six cleansers. The participants ranked their perceived feelings of skin tightness after using the formula they were given.
“We plotted what we were predicting against what human subjects were telling us, and it all fell on a straight line. In other words, we were predicting exactly what they were telling us,” Dauskardt said. “It was an absolutely remarkable correlation with a very high statistical significance.”
Shaping new developments
The ability to understand and predict how people will feel after using a skin treatment could help cosmetics companies improve their formulations before bringing in people to test them. And with such a detailed model of how mechanical stresses are transferred through skin layers, these methods could potentially be used to evaluate more than just the feeling of tightness, Dauskardt said.
“It provides a framework for the development of new products,” Dauskardt said. “If you’re doing anything to the outer layer of the skin that’s causing it to change its strain state and its stress state, then we can tell you how that information is transmitted and how it will be understood and reported by consumers.”
Dauskardt is also looking to apply this new understanding to the development of wearable devices. For example, if we know how our brains interpret minute changes in skin tension, we might be able to harness that mechanism to send intentional signals. In the same way that a person reading braille translates sensations on their fingertip into words, a device creating tiny mechanical changes on our skin might be able to convey information.
“What we’ve done is reveal how mechanical information gets from the outer stratum corneum layer down to the neurons much lower in the skin layers,” Dauskardt said. “So now, can we communicate through human skin? Can we build a device to provide information to someone non-verbally, non-visually, using our understanding of these mechanisms? That’s one of the areas we’re very interested in.”
Dauskardt is a member of Stanford Bio-X , the Cardiovascular Institute, the Wu Tsai Human Performance Alliance, and the Wu Tsai Neurosciences Institute, and an affiliate of the Precourt Institute for Energy and the Stanford Woods Institute for the Environment.
Additional Stanford co-authors of this research include doctoral students Ross Bennett-Kennett and Joseph Pace. Other co-authors are from L’Oréal Research and Innovation.
Funding: This work was funded by L’Oréal Research and Innovation.
About this neuroscience research news
Author:Jill Wu Source: Stanford Contact: Jill Wu – Stanford Image: The image is credited to Neuroscience News
Sensory neuron activation from topical treatments modulates the sensorial perception of human skin
Neural signaling of skin sensory perception from topical treatments is often reported in subjective terms such as a sensation of skin “tightness” after using a cleanser or “softness” after applying a moisturizer.
However, the mechanism whereby cutaneous mechanoreceptors and corresponding sensory neurons are activated giving rise to these perceptions has not been established.
Here, we provide a quantitative approach that couples in vitro biomechanical testing and detailed computational neural stimulation modeling along with a comprehensive in vivo self-assessment survey to demonstrate how cutaneous biomechanical changes in response to treatments are involved in the sensorial perception of the human skin.
Strong correlations are identified between reported perception up to 12 hours post treatment and changes in the computed neural stimulation from mechanoreceptors residing deep under the skin surface.
The study reveals a quantitative framework for understanding the biomechanical neural activation mechanism and the subjective perception by individuals.