A team of biologists has identified a set of nerve cells in desert locusts that bring about ‘gang-like’ gregarious behaviour when they are forced into a crowd.
Dr Swidbert Ott from the University of Leicester’s Department of Biology, working with Dr Steve Rogers at the University of Sydney, Australia, has published a study that reveals how newly identified nerve cells in locusts produce the neurochemical serotonin to initiate changes in their behaviour and lifestyle.
The findings demonstrate the importance of individual history for understanding how brain chemicals control behaviour, which may apply more broadly to humans also.
Locusts are normally shy, solitary animals that actively avoid the company of other locusts. But when they are forced into contact with other locusts, they undergo a radical change in behaviour – they enter a ‘bolder’ gregarious state where they are attracted to the company of other locusts. This is the critical first step towards the formation of the notorious locust swarms.
Dr Ott said: “Locusts only have a small number of nerve cells that can synthesise serotonin. Now we have found that of these, a very select few respond specifically when a locust is first forced to be with other locusts. Within an hour, they produce more serotonin.
“It is these few cells that we think are responsible for the transformation of a loner into a gang member. In the long run, however, many of the other serotonin-cells also change, albeit towards making less serotonin.”
When a locust is first forced into contact with other locusts, a specific set of nerve cells that produce the neurochemical serotonin is responsible for reconfiguring its behaviour so that the previously solitary locust becomes a member of the gang, which is known as ‘gregarious’ behaviour.
An entirely different set of its serotonin-producing nerve cells is then affected by life in the group in the long run.
Dr Ott added: “The key to our success was to look in locusts that have just become gregarious and that had never met another locust until an hour earlier. If we had looked only in solitary locusts and in locusts that had a life-long history of living in crowds, we would have missed the nerve cells that are the key players in the transformation.
“There is an important lesson here for understanding the mechanisms that drive changes in social behaviour in general, both in locusts and in humans. We have shown how important it is to look at what happens when a new social behaviour is first set up, not just at the long-term outcome.
“Research in insects can give us deep insights into how brains work in general, including our own.”
Studies have previously shown that the change from solitary to gregarious behaviour is caused by serotonin.
The new study, which was funded by the Leverhulme Trust, the Biotechnology and Biological Sciences Research Council (BBSRC) and the Royal Society, has identified the individual serotonin-producing nerve cells that are responsible for the switch from solitary to gregarious behaviour.
The scientists used a fluorescent stain that reveals the serotonin-producing nerve cells under the microscope. This allowed them to measure the amount of serotonin in individual nerve cells — the brighter a nerve cell lights up, the more serotonin it contains. The newly identified cells were much brighter in locusts that had just been forcedly crowded with other locusts. Moreover, the same cells were also brighter in locusts that had their hind legs tickled by the researchers for an hour — which is sufficient to make the locusts behave gregariously.
Serotonin has important roles in the brains of all animals that include the regulation of moods and social interactions.
In humans, there are strong links between changes in serotonin and mental disorders such as depression and anxiety.
Study shows ‘swarm’ mentality in locusts is a result of specific nerve cells that produce the brain chemical serotonin
Serotonin in humans is known to affect mood and behaviour such as aggression and anxiety
Research in insects can give us deep insights into how brains work in general, including the human brain
About this neuroscience research
Contact: Dr Swidbert Ott – University of Leicester Source:University of Leicester press release Image Source: The image is credited to the Researchers/University of Leicester and is adapted from the press release Original Research: Full open access research for “Differential activation of serotonergic neurons during short- and long-term gregarization of desert locusts” by Stephen M. Rogers and Swidbert R. Ott in Proceedings of the Royal Society B: Biological Sciences. Published online December 17 2014 doi:10.1098/rspb.2014.2062
Open Access Neuroscience Abstract
Differential activation of serotonergic neurons during short- and long-term gregarization of desert locusts
Serotonin is a neurochemical with evolutionarily conserved roles in orchestrating nervous system function and behavioural plasticity. A dramatic example is the rapid transformation of desert locusts from cryptic asocial animals into gregarious crop pests that occurs when drought forces them to accumulate on dwindling resources, triggering a profound alteration of behaviour within just a few hours. The onset of crowding induces a surge in serotonin within their thoracic ganglia that is sufficient and necessary to induce the switch from solitarious to gregarious behaviour. To identify the neurons responsible, we have analysed how acute exposure to three gregarizing stimuli—crowding, touching the hind legs or seeing and smelling other locusts—and prolonged group living affect the expression of serotonin in individual neurons in the thoracic ganglia. Quantitative analysis of cell body immunofluorescence revealed three classes of neurons with distinct expressional responses. All ganglia contained neurons that responded to multiple gregarizing stimuli with increased expression. A second class showed increased expression only in response to intense visual and olfactory stimuli from conspecifics. Prolonged group living affected a third and entirely different set of neurons, revealing a two-tiered role of the serotonergic system as both initiator and substrate of socially induced plasticity. This demonstrates the critical importance of ontogenetic time for understanding the function of serotonin in the reorganization of behaviour.
“Differential activation of serotonergic neurons during short- and long-term gregarization of desert locusts” by Stephen M. Rogers and Swidbert R. Ott in Proceedings of the Royal Society B: Biological Sciences doi:10.1098/rspb.2014.2062.