Saturated Fatty Acid Levels Increase When Making Memories

Summary: Saturated fatty acid levels rise in the brain during the formation of new memories, researchers say. The highest levels of saturated fatty acids were found in the amygdala, an area of the brain associated with fear and emotional memories.

Source: University of Queensland

Saturated fatty acid levels unexpectedly rise in the brain during memory formation, according to research, opening a new avenue of investigation into how memories are made.

Dr Tristan Wallis, from Professor Frederic Meunier’s laboratory at UQ’s Queensland Brain Institute (QBI), said traditionally, polyunsaturated fatty acids were considered important to health and memory, but this study highlighted the unexpected role of saturated fatty acids.

“We tested the most common fatty acids to see how their levels changed as new memories were formed in the brain,” Dr Wallis said.

“Unexpectedly, the changes of saturated fat levels in the brain cells were the most marked, especially that of myristic acid, which is found in coconut oil and butter.

“In the kitchen, saturated fats are those which are solid at room temperature while unsaturated fats are normally liquid.

“The brain is the fattiest organ in the body, being 60 per cent fat, which provides energy, structure and assists in passing messages between brain cells.

“Fatty acids are the building blocks of lipids or fats and are vital for communication between nerve cells, because they help synaptic vesicles — microscopic sacs containing neurotransmitters–to fuse with the cell membrane and pass messages between the cells.

This shows a brain
The highest concentration of saturated fatty acids was found in the amygdala — the part of the brain involved in forming new memories specifically related to fear and strong emotions. Image is in the public domain

“We have previously shown that when brain cells communicate with each other in a dish, the levels of saturated fatty acids increase.”

Researchers have found that fatty acid levels in the rat brain, particularly saturated fatty acids, increase as memories are formed, but when they used a drug to block learning and memory formation in rats, the fatty acid levels did not change.

The highest concentration of saturated fatty acids was found in the amygdala — the part of the brain involved in forming new memories specifically related to fear and strong emotions.

Study contributor and QBI Director Professor Pankaj Sah said the work opened a new avenue on how memory was formed.

“This research has huge implications on our understanding of synaptic plasticity — the change that occurs at the junctions between neurons that allow them to communicate, learn and build memories,” Professor Sah said.

Funding: This work is published in Nature Communications and supported by National Health and Medical Research Council (NHMRC) and the Australian Research Council Grant.

About this memory research news

Source: University of Queensland
Contact: Jane Ilsley – University of Queensland
Image: The image is in the public domain

Original Research: Open access.
Saturated free fatty acids and association with memory formation” by Tristan P. Wallis, Bharat G. Venkatesh, Vinod K. Narayana, David Kvaskoff, Alan Ho, Robert K. Sullivan, François Windels, Pankaj Sah & Frédéric A. Meunier. Nature Communications


Saturated free fatty acids and association with memory formation

Polyunsaturated free fatty acids (FFAs) such as arachidonic acid, released by phospholipase activity on membrane phospholipids, have long been considered beneficial for learning and memory and are known modulators of neurotransmission and synaptic plasticity. However, the precise nature of other FFA and phospholipid changes in specific areas of the brain during learning is unknown.

Here, using a targeted lipidomics approach to characterise FFAs and phospholipids across the rat brain, we demonstrated that the highest concentrations of these analytes were found in areas of the brain classically involved in fear learning and memory, such as the amygdala.

Auditory fear conditioning led to an increase in saturated (particularly myristic and palmitic acids) and to a lesser extent unsaturated FFAs (predominantly arachidonic acid) in the amygdala and prefrontal cortex. Both fear conditioning and changes in FFA required activation of NMDA receptors.

These results suggest a role for saturated FFAs in memory acquisition.

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