Summary: Patients with severe Alzheimer’s disease experienced remarkable improvements in both behavior and cognition within days of receiving low-dose radiation treatment.
Individuals living with severe Alzheimer’s disease showed remarkable improvements in behaviour and cognition within days of receiving an innovative new treatment that delivered low doses of radiation, a recent Baycrest-Sunnybrook pilot study found.
“The primary goal of a therapy for Alzheimer’s disease should be to improve the patient’s quality of life. We want to optimize their well-being and restore communication with family and friends to avoid social isolation, loneliness and under-stimulation. Although the study was a small pilot and should be interpreted with caution, our results suggest that low-dose radiation therapy may successfully achieve this,” says Dr. Morris Freedman, scientist at Baycrest’s Rotman Research Institute, head of the division of neurology at Baycrest and senior author of the study.
The study was a clinical follow-up to a 2015 case report about a patient in hospice with Alzheimer’s disease. After being treated several times with radiation to her brain, she showed such significant improvements in cognition, speech, movement and appetite that she was discharged from the hospice to a long-term care home for older adults.
High doses of radiation are known to have harmful effects on our health. However, low doses, such as those used for diagnostic CT scans, can help the body protect and repair itself.
“Numerous neurological disorders, including Alzheimer’s disease, are thought to be caused in part by oxidative stress that damages all cells, including those in the brain. We have natural protection systems to combat the damage, but they become less effective as we get older. Each dose of radiation stimulates our natural protection systems to work harder – to produce more antioxidants that prevent oxidative damage, to repair more DNA damage and to destroy more mutated cells,” says Dr. Jerry Cuttler, a retired Atomic Energy of Canada scientist. He has been researching the effects of radiation on health for more than 25 years and is the lead author of the study.
In this study, published in the Journal of Alzheimer’s Disease, four individuals living with severe Alzheimer’s disease were given three treatments of low-dose radiation, each spaced two weeks apart. A CT scanner at Sunnybrook Health Sciences Centre was employed to provide the treatments, with the supervision and support of Dr. Sandra Black, senior scientist and neurologist, and Dr. Sean Symons, radiologist-in-chief, both at Sunnybrook.
The researchers used standardized tests and observation to record changes in the patients’ communication and behaviour after the treatment. Most importantly, they collected information (descriptions, photos and videos) from the patients’ spouse, children and caregivers.
Remarkably, three of the four individuals showed improvements within one day of the first treatment, with their relatives reporting increased alertness and responsiveness, recognition of loved ones, mobility, social engagement, mood and more.
Two days after the first treatment, the son of one of the patients reported, “When I said hello, she looked at me and said, ‘Hello dear.’ She hadn’t said this to me in years!”
The daughter of another patient noted: “I had an amazing visit with my dad this evening. I’m speechless from last night. He was excited to see me – he spoke to me right away and gave me multiple kisses – real kisses like years ago. He was clapping his hands to the music. My mom agreed it’s been years since he has done this. Everyone is amazed.”
The results of this study offer hope for those with severe Alzheimer’s disease and their loved ones. However, it is important to note that this was a small pilot study with some limitations, including missing a placebo group. Future research is needed to examine the effects of this novel therapy in larger clinical trials.
Funding: Dr. Freedman, senior author, was supported in part by the Saul A. Silverman Family Foundation as part of the Canada International Scientific Exchange Program (MF), and the Morris Kerzner Memorial Fund.
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Source: Baycrest Contact: Sophie Boisvert-Hearn – Baycrest Image: The image is in the public domain
Low Doses of Ionizing Radiation as a Treatment for Alzheimer’s Disease: A Pilot Study
In 2015, a patient in hospice with Alzheimer’s disease (AD) was treated with ionizing radiation to her brain using repeated CT scans. Improvement in cognition, speech, movement, and appetite was observed. These improvements were so momentous that she was discharged from the hospice to a long-term care home. Based on this case, we conducted a pilot clinical trial to examine the effect of low-dose ionizing radiation (LDIR) in severe AD.
To determine whether the previously reported benefits of LDIR in a single case with AD could be observed again in other cases with AD when the same treatments are given.
In this single-arm study, four patients were treated with three consecutive treatments of LDIR, each spaced two weeks apart. Qualitative changes in communication and behavior with close relatives were observed and recorded. Quantitative measures of cognition and behavior were administered pre and post LDIR treatments.
Minor improvements on quantitative measures were noted in three of the four patients following treatment. However, the qualitative observations of cognition and behavior suggested remarkable improvements within days post-treatment, including greater overall alertness. One patient showed no change.
LDIR may be a promising, albeit controversial therapy for AD. Trials of patients with less severe AD, double-blind and placebo-controlled, should be carried out to determine the benefits of LDIR. Quantitative measures are needed that are sensitive to the remarkable changes induced by LDIR, such as biological markers of oxidative stress that are associated with AD.