Placebo Reduces Feelings of Guilt

Summary: Placebos can help reduce feelings of guilt, even when the placebo is given openly, a new study reports.

Source: University of Basel

People don’t always behave impeccably in relationship to others. When we notice that this has inadvertently caused harm, we often feel guilty. This is an uncomfortable feeling and motivates us to take remedial action, such as apologizing or owning up.

This is why guilt is considered an important moral emotion, as long as it is adaptive – in other words, appropriate and in proportion to the situation.

“It can improve interpersonal relationships and is therefore valuable for social cohesion,” says Dilan Sezer, researcher at the Division of Clinical Psychology and Psychotherapy at the University of Basel.

Whether feelings of guilt can be reduced by taking placebos is something that researchers at the Faculty of Psychology at the University of Basel have been exploring.

Their findings have now been published in the journal Scientific Reports.

Open-label placebos work

In order to arouse feelings of guilt, test subjects in the study were asked to write about a time when they had disregarded important rules of conduct, or treated someone close to them unfairly, hurt or even harmed them. The idea was that the study participants should still feel bad about the chosen situation.

Participants were then randomized to three conditions: Participants in one group were given placebo pills with being deceptively told that this was a real medication while participants in another group were told that they are given a placebo. Both groups were told that what they had been given will be effective against feelings of guilt.

The control group was given no treatment at all. The results showed that feelings of guilt were significantly reduced in both placebo groups compared with those without medication.

This was also the case when the subjects knew they had been given a placebo. 

“Our study therefore supports the intriguing finding that placebos work even when they are administered openly, and that explanation of the treatment is key to its effectiveness,” states the study’s lead author, Dilan Sezer. Participants in this study were all healthy, had no psychiatric disorders and were not being treated with psychotropics.

Clinical applicability not yet proven

Where feelings of guilt are irrational and continue for longer periods of time, they are considered maladaptive – in other words, disproportionate. These emotions can affect people’s health and are also, among other things, a common symptom of depression.

This shows the outline of two heads
Where feelings of guilt are irrational and continue for longer periods of time, they are considered maladaptive – in other words, disproportionate. Image is in the public domain

Scientific studies have shown that placebo effects can be powerful in treating depression. But the finding that open-label placebos can also be useful for such strong emotions as guilt is new. It stands to reason, says Dilan Sezer, that we should try to harness these effects to help those affected.

“The administering of open-label placebos, in particular, is a promising approach, as it preserves patient autonomy by allowing patients to be fully aware of how the intervention works.”

The results of the study are an initial promising step in the direction of symptom-specific and more ethical treatments for psychological complaints using open-label placebos, Sezer continues.

Further research will need to be done into whether it is possible to treat maladaptive guilt with placebos. And it is still not known whether similar effects are also possible with other feeling states. For Dilan Sezer, one thing is certain: “Using open-label placebos would be an inexpensive and straightforward treatment option for many psychological and physical complaints.”

About this psychology research news

Author: Noëmi Kern
Source: University of Basel
Contact: Noëmi Kern – University of Basel
Image: The image is in the public domain

Original Research: Open access.
Deceptive and open-label placebo effects in experimentally induced guilt: a randomized controlled trial in healthy subjects” by Dilan Sezer et al. Scientific Reports


Deceptive and open-label placebo effects in experimentally induced guilt: a randomized controlled trial in healthy subjects

Placebos are known to yield significant effects in many conditions. We examined deceptive and open-label placebo effects on guilt, which is important for self-regulation and a symptom of mental disorders.

Following an experimental induction of guilt, healthy subjects were randomized to deceptive placebo (DP; n = 35), open-label placebo (OLP; n = 35), or no treatment (NT; n = 39). The primary outcome was guilt responses assessed in area under the curve (AUC). Secondary outcomes were shame, guilt, and affect.

We hypothesized that DP and OLP would reduce guilt compared to NT. Guilt responses were higher in the NT group than in the placebo groups (estimate = 2.03, 95% CI = 0.24–3.82, d = 0.53), whereas AUC guilt did not differ significantly between the placebo groups (estimate = −0.38, 95% CI = −2.52–1.76, d = −0.09).

Placebos are efficacious in reducing acute guilt responses, regardless of the placebo administration (i.e., open vs. deceptive).

Furthermore, we observed narrative-specific effects with significant changes of guilt but not shame, pride, or affect.

These results indicate not only that guilt is amenable to placebos but also that placebos can be administered in an ethical and potentially emotion-specific manner.

Join our Newsletter
I agree to have my personal information transferred to AWeber for Neuroscience Newsletter ( more information )
Sign up to receive our recent neuroscience headlines and summaries sent to your email once a day, totally free.
We hate spam and only use your email to contact you about newsletters. You can cancel your subscription any time.