Neuroscience research articles are provided.
What is neuroscience? Neuroscience is the scientific study of nervous systems. Neuroscience can involve research from many branches of science including those involving neurology, brain science, neurobiology, psychology, computer science, artificial intelligence, statistics, prosthetics, neuroimaging, engineering, medicine, physics, mathematics, pharmacology, electrophysiology, biology, robotics and technology.
– These articles focus mainly on neurology research. – What is neurology? – Definition of neurology: a science involved in the study of the nervous systems, especially of the diseases and disorders affecting them. – Neurology research can include information involving brain research, neurological disorders, medicine, brain cancer, peripheral nervous systems, central nervous systems, nerve damage, brain tumors, seizures, neurosurgery, electrophysiology, BMI, brain injuries, paralysis and spinal cord treatments.
What is Psychology? Definition of Psychology: Psychology is the study of behavior in an individual, or group. Psychology news articles are listed below.
Artificial Intelligence articles involve programming, neural engineering, artificial neural networks, artificial life, a-life, floyds, boids, emergence, machine learning, neuralbots, neuralrobotics, computational neuroscience and more involving A.I. research.
Robotics articles will cover robotics research press releases. Robotics news from universities, labs, researchers, engineers, students, high schools, conventions, competitions and more are posted and welcome.
Genetics articles related to neuroscience research will be listed here.
Neurotechnology research articles deal with robotics, AI, deep learning, machine learning, Brain Computer Interfaces, neuroprosthetics, neural implants and more. Read the latest neurotech news articles below.
Summary: A new insect study reveals a preference for ethanol persisted for five generations following paternal exposure. The findings shed light on the role paternal experience plays across generations in disease and risks for addiction in humans.
Source: The Geisel School of Medicine at Dartmouth
Are our personalities and behaviors shaped more by our genes or our circumstances? While this age-old “nature vs. nurture” question continues to confound us and fuel debates, a growing body of evidence from research conducted over recent decades suggests that parental environment can have a profound impact on future generations.
Results of a new Dartmouth study published this week in the journal eLife — which examined how environmental stressors put on fruit flies (Drosophila melanogaster) can influence the phenotypes of their offspring–are adding some intriguing findings to the mix.
“While neuronally encoded behavior isn’t thought to be inherited across generations, we wanted to test the possibility that environmentally triggered modifications could allow ‘memory’ of parental experiences to be inherited,” explains Julianna “Lita” Bozler, a PhD candidate in the Bosco Lab at the Geisel School of Medicine, who served as lead author on the study.
When exposed to parasitoid wasps–which deposit their eggs into and kill the larvae of fruit flies–Drosophila melanogaster females are known to shift their preference to food containing ethanol as an egg-laying substrate, which protects their larvae from wasp infection.
For the study, the fruit flies were cohabitated with female wasps for four days before their eggs were collected. The embryos were separated into two cohorts–a wasp-exposed and unexposed (control) group–and developed to maturity without any contact with adult flies or wasps. One group was used to propagate the next generation and the other was analyzed for ethanol preference.
“We found that the original wasp-exposed flies laid about 94 percent of their eggs on ethanol food and that this behavior persisted in their offspring, even though they’d never had direct interaction with wasps,” says Bozler.
The ethanol preference was less potent in the first-generation offspring, with 73 percent of their eggs laid on ethanol food. “But remarkably, this inherited ethanol preference persisted for five generations, gradually reverting back to a pre-wasp exposed level,” she says. “This tells us that inheritance of ethanol preference is not a permanent germline change, but rather a reversible trait.”
Importantly, the research team determined that one of the critical factors driving ethanol preference behavior is the depression of Neuropeptide-F (NPF) that is imprinted in a specific region of the female fly’s brain. While this change, based in part on visual signals, was required to initiate transgenerational inheritance, both male and female progeny were able to pass on ethanol preference to their offspring.
“We’re very excited about the findings that Lita and her lab partner, Balint Kacsoh have made,” says Giovanni Bosco, Ph.D., a professor of molecular and systems biology at Geisel, who directs the Bosco Lab. “They are allowing us to better understand not only the biology and epigenetics of fruit flies but also some of the foundational mechanisms upon which biologic inheritance is based.
“Of particular interest, are the conserved signaling functions of NPF and its mammalian counterpart NPY in humans,” he says.
“We hope that our findings may lead to greater insights into the role that parental experiences play across generations in diseases such as drug and alcohol disorders.”
Funding: This study received support from the National Institutes of Health (grant numbers 1DP1MH110234 and T32-GM009704) and Defense Advanced Research Projects Agency (HR0011-15-1-0002).
[divider]About this neuroscience research article[/divider]
Source: The Geisel School of Medicine at Dartmouth Media Contacts: Tim Dean – The Geisel School of Medicine at Dartmouth Image Source: The image is in the public domain.
Original Research: Open access “Transgeneratonal inheritance of ethanol preference is caused by maternal NPF repression”. Julianna Bozler, Balint Z Kacsoh, Giovanni Bosco. eLife. doi:10.7554/eLife.45391
Transgeneratonal inheritance of ethanol preference is caused by maternal NPF repression
Rapid or even anticipatory adaptation to environmental conditions can provide a decisive fitness advantage to an organism. The memory of recurring conditions could also benefit future generations; however, neuronally-encoded behavior isn’t thought to be inherited across generations. We tested the possibility that environmentally triggered modifications could allow ‘memory’ of parental experiences to be inherited. In Drosophila melanogaster, exposure to predatory wasps leads to inheritance of a predisposition for ethanol-rich food for five generations. Inhibition of Neuropeptide-F (NPF) activates germline caspases required for transgenerational ethanol preference. Further, inheritance of low NPF expression in specific regions of F1 brains is required for the transmission of this food preference: a maternally derived NPF locus is necessary for this phenomenon, implicating a maternal epigenetic mechanism of NPF-repression. Given the conserved signaling functions of NPF and its mammalian NPY homolog in drug and alcohol disorders, these observations raise the intriguing possibility of NPY-related transgenerational effects in humans.
[divider]Feel free to share this Neuroscience News.[/divider]