Specific inhibitory neurons in the prefrontal cortex appear to become persistently activated following acute stress. The findings may pave the way for the creation of more targeted therapeutics for stress.
Hippocampal HCN channels are more highly expressed in people with major depressive disorder. Antidepressants that increase cAMP signaling interfere with TRIP8b's ability to bind to HCN channels, helping to restore cognitive ability in those with MDD.
An increased white blood cell count has been linked to increased depression polygenic scores. The findings highlight the importance of the immune system in the development and severity of depression.
Ketamine's rapid antidepressant action is due to specific synaptic effects, researchers report.
A new study finds dopamine increases responses to stressful stimuli, not just pleasurable ones. The findings could have implications for the treatment of mental health disorders and addiction.
In the absence of neural activity, BDNF expression can still be activated. The findings shed light on how therapeutic ketamine used has an antidepressant effect and how it works in both the long and short term.
A group of neurons located in the basal ganglia appears to play a vital role in cognitive flexibility.