Regular exercise modulates iron storage and trafficking in the brain and skeletal muscles, and physical activity reduces cortical hepcidin. The findings reveal how exercise can be beneficial for those with Alzheimer's disease.
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A new deep learning algorithm can distinguish different sleep stages. The technology could help with diagnosing sleep disorders, such as obstructive sleep apnea.
Alzheimer's patients who used antipsychotics had a 29% increased risk of head injury and a 22% higher risk of TBI compared to others with the neurodegenerative disease who did not use the medications.
Researchers discovered increased inflammatory activity in a subgroup of patients with frontotemporal dementia. The increased inflammation was indicated by elevated levels of cytokines known to increase inflammatory response and decreased levels of IL-10, which reduces inflammation. The inflammation was associated with Parkinsonism's symptoms and rapid cognitive and functional decline. The study also revealed patients with FTD are less likely to develop cancer.
APOE4 increases the inflammatory response of human microglia while reducing cellular migration. The gene also impairs the metabolic activity of the immune cells. The findings show APOE4 has a profound impact on the basic functions of microglia.
Schizophrenia is linked to alterations in pathways associated with glycosaminoglycan, neurotransmitter metabolism, and GABAergic synapses. A large percentage of genes related to schizophrenia are expressed differently between males and females. The results imply the mechanisms involved in schizophrenia development differ, at least slightly, between males and females.
Psychopathy is associated with altered expression of genes and immune responses related to molecular pathways. In neurons, the up-regulation of PRL10P9 and ZNF132 and down-regulation of CDG5 and OPRD1 were linked to psychopathic behaviors. The genetic expression explained up to 92% of the variance of psychopathic symptoms. Researchers speculated these genes may be relevant to the lack of empathy and emotional callousness associated with psychopathy, as previous studies have linked a number of these genes to ASD and problematic social behaviors.
Adding extra choline through eggs or meat to your daily diet could help stave off the effects of dementia. Higher phosphatidylcholine intake through diet was associated with lower rates of dementia and improved cognitive function in aging men.