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University of Eastern Finland

Featured Genetics Neuroscience Open Neuroscience Articles

·September 25, 2020·5 min read

A Genetic Variant That Protects Against Alzheimer’s Promotes Immune Cell Functions

PLCG2-P522R, a genetic variant that protects against Alzheimer's disease, enhances key functions of immune cells.

Featured Genetics Neuroscience Open Neuroscience Articles Psychology

·August 29, 2019·3 min read

Abnormal expression of genes in psychopathy

Psychopathy is associated with altered expression of genes and immune responses related to molecular pathways. In neurons, the up-regulation of PRL10P9 and ZNF132 and down-regulation of CDG5 and OPRD1 were linked to psychopathic behaviors. The genetic expression explained up to 92% of the variance of psychopathic symptoms. Researchers speculated these genes may be relevant to the lack of empathy and emotional callousness associated with psychopathy, as previous studies have linked a number of these genes to ASD and problematic social behaviors.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·September 16, 2019·4 min read

Alzheimer’s disease risk gene APOE4 impairs function of brain immune cells

APOE4 increases the inflammatory response of human microglia while reducing cellular migration. The gene also impairs the metabolic activity of the immune cells. The findings show APOE4 has a profound impact on the basic functions of microglia.

Featured Neurology

·April 9, 2018·3 min read

Antiepileptic Drugs Increase Risk of Alzheimer’s

A new study reveals antiepileptic drugs with side effects of impairing cognitive function can increase the risk of patients developing dementia and Alzheimer's disease. Additionally, the higher the dose of the medication used, the greater the risk of developing dementia, researchers report.

Featured Neurology Neuroscience

·January 16, 2020·3 min read

Antipsychotics associated with increased risk of head & brain injuries in persons with Alzheimer’s disease

Alzheimer's patients who used antipsychotics had a 29% increased risk of head injury and a 22% higher risk of TBI compared to others with the neurodegenerative disease who did not use the medications.

Featured Neurology Neuroscience Open Neuroscience Articles

·November 17, 2017·4 min read

Astrocytes Linked to Alzheimer’s Disease

Researchers have discovered a direct association between astrocytes and Alzheimer's disease. In a new study, researchers report astrocytes in the brains of Alzheimer's patients produced significantly more amyloid beta than astrocytes in the brains of people without the disease.

Image shows how alzheimer's affects the brain.

Featured Neurology Neuroscience

·November 20, 2017·3 min read

Benzodiazepines Increase Mortality in Persons with Alzheimer’s Disease

Researchers report an elevated risk of death in Alzheimer's patients who use benzodiazapines.

Featured Neuroscience

·December 17, 2018·4 min read

Boys with Good Motor Skills Excel at Problem Solving Too

Researchers report boys with better motor skills tend to have higher cognitive scores over a two year follow up period than those with poorer motor skills. Additionally, boys with higher aerobic fitness had poorer cognition during the two year follow up than those with lower fitness levels.

Featured Genetics Psychology

·February 21, 2018·3 min read

Depression Linked to Reduced Arginine Levels

Researchers have identified a link between reduced arginine levels and major depressive disorder.

Featured Neurology Neuroscience

·August 6, 2019·4 min read

Dietary choline associated with reduced risk of dementia

Adding extra choline through eggs or meat to your daily diet could help stave off the effects of dementia. Higher phosphatidylcholine intake through diet was associated with lower rates of dementia and improved cognitive function in aging men.

Featured Neuroscience

·July 1, 2018·3 min read

Drinking Changes Young Adults’ Metabolite Profile

Researchers report metabolite profiles alter in young people who consume alcohol at socially acceptable levels. Additionally, researchers found reduced gray matter volume in young women who are heavy drinkers.

Featured Genetics Neurology Neuroscience Open Neuroscience Articles

·October 16, 2019·4 min read

Frontotemporal dementia is associated with alterations in immune system function

Researchers discovered increased inflammatory activity in a subgroup of patients with frontotemporal dementia. The increased inflammation was indicated by elevated levels of cytokines known to increase inflammatory response and decreased levels of IL-10, which reduces inflammation. The inflammation was associated with Parkinsonism's symptoms and rapid cognitive and functional decline. The study also revealed patients with FTD are less likely to develop cancer.

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University of Eastern Finland

A Genetic Variant That Protects Against Alzheimer’s Promotes Immune Cell Functions

Abnormal expression of genes in psychopathy

Alzheimer’s disease risk gene APOE4 impairs function of brain immune cells

Antiepileptic Drugs Increase Risk of Alzheimer’s

Antipsychotics associated with increased risk of head & brain injuries in persons with Alzheimer’s disease

Astrocytes Linked to Alzheimer’s Disease

Benzodiazepines Increase Mortality in Persons with Alzheimer’s Disease

Boys with Good Motor Skills Excel at Problem Solving Too

Depression Linked to Reduced Arginine Levels

Dietary choline associated with reduced risk of dementia

Drinking Changes Young Adults’ Metabolite Profile

Frontotemporal dementia is associated with alterations in immune system function

Untangling the Human Mind: The Interplay Between Cognition and Personality

Empathy’s Influence on Drinking Patterns

Sleep Apnea and Its Link to Alzheimer’s Associated Brain Changes

Getting the Skinny on Cannabis Use: The Effect of Cannabis on Weight and Metabolism

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