Researchers discovered increased inflammatory activity in a subgroup of patients with frontotemporal dementia. The increased inflammation was indicated by elevated levels of cytokines known to increase inflammatory response and decreased levels of IL-10, which reduces inflammation. The inflammation was associated with Parkinsonism's symptoms and rapid cognitive and functional decline. The study also revealed patients with FTD are less likely to develop cancer.
Alzheimer's patients who used antipsychotics had a 29% increased risk of head injury and a 22% higher risk of TBI compared to others with the neurodegenerative disease who did not use the medications.
According to researchers, there is no link between psychiatric disorders and an increased risk of developing Alzheimer's disease.
Schizophrenia is linked to alterations in pathways associated with glycosaminoglycan, neurotransmitter metabolism, and GABAergic synapses. A large percentage of genes related to schizophrenia are expressed differently between males and females. The results imply the mechanisms involved in schizophrenia development differ, at least slightly, between males and females.
Regular exercise modulates iron storage and trafficking in the brain and skeletal muscles, and physical activity reduces cortical hepcidin. The findings reveal how exercise can be beneficial for those with Alzheimer's disease.
Researchers report boys with better motor skills tend to have higher cognitive scores over a two year follow up period than those with poorer motor skills. Additionally, boys with higher aerobic fitness had poorer cognition during the two year follow up than those with lower fitness levels.
A new study links frequent chronic headaches with lower serum vitamin D levels.
The Ph4-tm gene has been implicated in fear and anxiety. P4h-tm knockout mice showed diminished response to fear and showed more courageous behavior than wild-type mice with a functional P4h-tm gene.
APOE4 increases the inflammatory response of human microglia while reducing cellular migration. The gene also impairs the metabolic activity of the immune cells. The findings show APOE4 has a profound impact on the basic functions of microglia.