FeaturedNeurologyNeuroscience·April 9, 2025·2 min readDad’s Alzheimer’s May Raise Tau Levels in Your BrainNew research reveals that people with a father who had Alzheimer’s may be more vulnerable to the spread of tau protein in the brain, a hallmark of the disease. The study followed 243 individuals with a family history of Alzheimer’s over nearly seven years and found that those with affected fathers, especially women, showed greater tau buildup.Read More
FeaturedGeneticsNeurologyNeuroscience·November 11, 2024·4 min readTargeting Enzyme TYK2 Could Reduce Tau in Alzheimer’s DiseaseScientists have discovered that the enzyme TYK2 modifies tau proteins, leading to their accumulation in the brain—a key feature of Alzheimer’s disease and related dementias. By reducing TYK2 activity in animal models, researchers found tau buildup was decreased, suggesting TYK2 inhibitors could be a potential therapeutic pathway.Read More
FeaturedNeurologyNeuroscience·October 3, 2024·6 min readDual-Targeting Drug Halts Tau Accumulation in Alzheimer’sScientists have developed a drug that targets both major aggregation-promoting sites of the Tau protein, a key player in Alzheimer's disease. This peptide inhibitor, RI-AG03, effectively prevents Tau buildup in lab studies and fruit flies, offering hope for new Alzheimer's treatments.Read More
FeaturedNeurologyNeuroscience·September 7, 2024·5 min readTau Levels Predict Memory Loss in Alzheimer’sAlzheimer's disease (AD) progression varies based on the presence of tau and amyloid-beta (Aβ) proteins in the brain. Patients with high levels of both tau and Aβ experience rapid memory decline, while those with high Aβ but low tau show a slower progression. The research emphasizes that tau levels are crucial for diagnosing and managing AD effectively. This insight could lead to more personalized treatment strategies as biomarker technology advances.Read More
FeaturedNeurologyNeuroscience·August 30, 2024·5 min readTau May Protect Brain Cells from Oxidative DamageResearchers have discovered that the Tau protein, often linked to neurodegenerative diseases like Alzheimer's, also has a protective role in the brain. Tau helps combat oxidative stress by aiding in the formation of lipid droplets in glial cells, which sequester toxic lipids and protect neurons.Read More
FeaturedGeneticsNeurologyNeuroscience·February 6, 2023·5 min readOverlooked Tau-RNA Interaction May Play Key Role in DementiaThe interaction of Tau with RNA is a key stage in the development of Alzheimer's disease and other dementias.Read More
FeaturedNeurologyNeuroscience·February 2, 2023·6 min readBrain Cell Changes in Alzheimer’s Disease MappedA new method dubbed STARmap PLUS was utilized to track and map changes in tau and amyloid beta in the brain as Alzheimer's disease progressed in mouse models.Read More
FeaturedNeurologyNeuroscience·January 13, 2023·4 min readMysteries About Leading Biomarker for Alzheimer’s SolvedResearchers identify how taupT217, a toxic form of the Tau protein, spreads through the brain as Alzheimer's disease progresses.Read More
FeaturedNeurologyNeuroscience·January 6, 2023·4 min readInflammatory Trigger a New Clue in Alzheimer’s and PSPAn inflammatory trigger like one present during viral infections is elevated in those with Alzheimer's disease and progressive supranuclear palsy (PSP).Read More
FeaturedNeurologyNeuroscienceOpen Neuroscience Articles·December 28, 2022·7 min readNew Biomarker Test Can Detect Alzheimer’s Neurodegeneration in BloodA newly developed blood test can detect brain-derived tau (BD-tau), a biomarker of Alzheimer's disease neurodegeneration.Read More
FeaturedNeurologyNeuroscienceOpen Neuroscience Articles·August 29, 2022·3 min readProtein ‘Traffic Jam’ in Neurons Linked to NeurodegenerationDampening retromer activity slows down the trafficking of tau in neurodegenerative disorders, a new study reports.Read More
FeaturedNeurologyNeuroscience·August 11, 2022·6 min readResearchers Explore the “Dark Side” of Alzheimer’s Disease Revealing New BiomarkersA new collection of articles explores mapping brain overexcitability that underpins the dysregulation of vigilance, sleep-wake cycles, and validating effective biomarkers for Alzheimer's disease.Read More
