Latest

Tau

·July 22, 2025·6 min read

Synaptic Tau and Astrocytes Drive PSP Progression

ew research uncovers how tau pathology spreads and damages synapses in progressive supranuclear palsy (PSP). Using human postmortem tissue and live brain slice models, scientists showed tau accumulates in both pre- and postsynaptic terminals, likely propagating neuron-to-neuron.

Featured Genetics Neurology Neuroscience

·July 9, 2025·7 min read

Genes and Brain Wiring Team Up in Alzheimer’s Spread

A new study reveals how genes influence where and how Alzheimer’s-related tau protein spreads in the brain. By combining imaging, gene data, and advanced modeling, researchers uncovered four gene pathways that either amplify or resist tau buildup, depending on brain connectivity.

Featured Neurology Neuroscience

·May 30, 2025·4 min read

SSRIs Restore Brain Function in Alzheimer’s

A new study suggests that SSRIs, commonly prescribed antidepressants, may reduce biological markers of Alzheimer’s disease. In a cohort of 191 individuals, AD patients on SSRIs had lower levels of plasma phosphorylated tau-181, a key indicator of disease severity.

Featured Neurology Neuroscience

·May 29, 2025·6 min read

Sleep Aid May Protect Brain from Alzheimer’s Damage

A common sleep medication, lemborexant, may do more than promote rest—it appears to reduce harmful tau buildup and protect the brain from neurodegeneration in mouse models of Alzheimer’s disease. Researchers found that this orexin receptor antagonist not only restored healthier sleep patterns but also preserved brain structure and reduced inflammation.

Featured Neurology Neuroscience

·April 30, 2025·5 min read

Skin Test Detects Neurodegenerative Disease PSP with High Accuracy

Researchers have developed a skin-based test that can detect misfolded tau proteins specific to progressive supranuclear palsy (PSP), offering a faster, more accurate diagnosis than current methods. This breakthrough could improve patient assignment to clinical trials and eventually guide targeted, precision treatments.

Featured Neurology Neuroscience

·April 9, 2025·2 min read

Dad’s Alzheimer’s May Raise Tau Levels in Your Brain

New research reveals that people with a father who had Alzheimer’s may be more vulnerable to the spread of tau protein in the brain, a hallmark of the disease. The study followed 243 individuals with a family history of Alzheimer’s over nearly seven years and found that those with affected fathers, especially women, showed greater tau buildup.

Featured Genetics Neurology Neuroscience

·November 11, 2024·4 min read

Targeting Enzyme TYK2 Could Reduce Tau in Alzheimer’s Disease

Scientists have discovered that the enzyme TYK2 modifies tau proteins, leading to their accumulation in the brain—a key feature of Alzheimer’s disease and related dementias. By reducing TYK2 activity in animal models, researchers found tau buildup was decreased, suggesting TYK2 inhibitors could be a potential therapeutic pathway.

Featured Neurology Neuroscience

·October 3, 2024·6 min read

Dual-Targeting Drug Halts Tau Accumulation in Alzheimer’s

Scientists have developed a drug that targets both major aggregation-promoting sites of the Tau protein, a key player in Alzheimer's disease. This peptide inhibitor, RI-AG03, effectively prevents Tau buildup in lab studies and fruit flies, offering hope for new Alzheimer's treatments.

This shows butterflies flying from a head.

Featured Neurology Neuroscience

·September 7, 2024·5 min read

Tau Levels Predict Memory Loss in Alzheimer’s

Alzheimer's disease (AD) progression varies based on the presence of tau and amyloid-beta (Aβ) proteins in the brain. Patients with high levels of both tau and Aβ experience rapid memory decline, while those with high Aβ but low tau show a slower progression. The research emphasizes that tau levels are crucial for diagnosing and managing AD effectively. This insight could lead to more personalized treatment strategies as biomarker technology advances.

Featured Neurology Neuroscience

·August 30, 2024·5 min read

Tau May Protect Brain Cells from Oxidative Damage

Researchers have discovered that the Tau protein, often linked to neurodegenerative diseases like Alzheimer's, also has a protective role in the brain. Tau helps combat oxidative stress by aiding in the formation of lipid droplets in glial cells, which sequester toxic lipids and protect neurons.

Featured Genetics Neurology Neuroscience

·February 6, 2023·5 min read

Overlooked Tau-RNA Interaction May Play Key Role in Dementia

The interaction of Tau with RNA is a key stage in the development of Alzheimer's disease and other dementias.

This shows tau and amyloid in a brain slice

Featured Neurology Neuroscience

·February 2, 2023·6 min read

Brain Cell Changes in Alzheimer’s Disease Mapped

A new method dubbed STARmap PLUS was utilized to track and map changes in tau and amyloid beta in the brain as Alzheimer's disease progressed in mouse models.