Imaging and manipulating engrams at the cellular level provides important insights into memory function. Read More
Motor learning induces widespread cortical synaptic potentiation by increasing the trafficking of AMPAR into dendritic spines. Read More
AMPA receptors form and disintegrate continually, rather than existing as stable entities. The findings shed light on the early stages of synaptic plasticity. Read More
Microglia play a critical role in reorganizing neural connections, fighting infections, and repairing damage to neurons while we sleep. Read More
New memories are laid down via different mechanisms in older mice compared to younger mice. Additionally, synaptic changes linked to new memory formation were harder to modify in older mice. Read More
Opiate exposure causes synaptic rewiring in the nucleus accumbens in addition to decreasing dendritic spines. The findings shed light into the neurobiology of opiate relapse. Read More
A lack of oxygen as a result of preterm birth does not cause hippocampal neurons to die but does impair hippocampal development. Hypoxia causes hippocampal cells to fail to mature normally, causing a reduction in long-term potentiation and impaired learning. Read More
Study reveals how CD2AP may enhance Alzheimer's susceptibility. The gene affects neural communication by regulating the levels of regulatory proteins present around synapses. Read More
Automated robotic technology allows researchers to identify new pathways activated when the brain rewires circuits in response to experience. Read More
Short bursts of exercise, equivalent to a pick-up game of basketball, boosts the function of a gene that increases dendritic spines in the hippocampus, helping to improve memory and learning. Read More
Hippocampal neurons become longer and stronger following a period of sleep deprivation. The study supports the hypothesis that sleep may weaken synapses, which are strengthened from learning, allowing for learning to occur after waking. Read More
A recurrent neural network algorithm demonstrates short-term synaptic plasticity can support short term maintenance of information, providing the memory delay period is sufficiently short. Read More
